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Options Available For Same A.s Genotype Couple - Family (5) - Nairaland

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Can Couple With Genotype AA & AS Give Birth To SS? / Wife Divorce Husband Because He Lied About His Genotype / Can A Man With Ac Genotype Marry A Woman With As Genotype (2) (3) (4)

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Re: Options Available For Same A.s Genotype Couple by Nobody: 10:02am On Jul 13, 2014
zz
Re: Options Available For Same A.s Genotype Couple by niceeric(m): 10:03am On Jul 13, 2014
Genea: My dear if you marry a As,u can do a bone marrow transplant if u av a SS as a child,am a medical student,i kno wat am saying and dere is a probability dat u can gv birth to ony one ss or none at all
Bone marrow transplant na like 5k abi??.........this is Nigeria ooo,kidney transplant dey make whole family dey show for NTA dey beg for money let alone bone marrow transplant....prevention is way better and cheaper than cure!

1 Like

Re: Options Available For Same A.s Genotype Couple by Nobody: 10:05am On Jul 13, 2014
zz

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Re: Options Available For Same A.s Genotype Couple by Tobiustobius: 10:06am On Jul 13, 2014
People are so uninformed about sickle cell disease and traits, it's really unfortunate. See advice to gamble with a child's life. Until you see a child ill for most of his [short] life, needing frequent blood transfusions just to stay alive, and in the end, begging you to let him die because he's tired of living in pain... Until you watch his parents cry over his body, the third child they've had to bury due to SSD... You'll understand what it means.

3 Likes

Re: Options Available For Same A.s Genotype Couple by arsetalks(m): 10:11am On Jul 13, 2014
rutchiekens:

Your statement is very rare that I have to ask if u've seen the children's medical report.

Some parents wouldn't want to disclose the genotype of their children especially if the children are sicklers because of stigma.
I did not see their medical reports but when you see a child that has the sickel cell gene, you will know. It is not as if they are still young. The youngest is 10.

I know them very well. Not that you certainly will have SS when you are AS and marry another AS. The stats say 1 in 4. However, I will never take such a risk having seen my own uncle lose his beautiful daughter after selling almost all he had.
Re: Options Available For Same A.s Genotype Couple by flyingdutchman(m): 10:16am On Jul 13, 2014
Pre Implantation Genetic Diagnosis (PGD). Its done after your sperm cell has been merged with the female egg, the result is the Embryo. This Embryo is tested for any sign of Sickle cell. The one(s) without the disease is/are replanted into your wife's womb and vuala! I could give you the link to good Clinics where its done, but you'd have to indicate your interest first. Before some ignorant, know-it-all, daft person condemns it

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Re: Options Available For Same A.s Genotype Couple by murphybo(m): 10:30am On Jul 13, 2014
I will rather ask for your genotype first than to ask for your love. so @op just take your time u gonna love again love is to human and it develops so u guys were never lovers from heaven u started here on earth which means u can love again BT its not easy BT u have to cope
Re: Options Available For Same A.s Genotype Couple by Nobody: 10:31am On Jul 13, 2014
zz
Re: Options Available For Same A.s Genotype Couple by royaltheo(m): 10:37am On Jul 13, 2014
I know in matters of the heart, the head bows! But trust me, u won't remember all the love nd emotions when your kids start having recurrent crises. All the best to you guys though. I feel your dilemma
Re: Options Available For Same A.s Genotype Couple by flyingdutchman(m): 10:41am On Jul 13, 2014
I read so so many comments from my fellow Nigerans and I could only reach one conclusion (sadly)- Nigerians don't do Research. We only hang on to information we had by chance over the 9'O Clock News. WHY DON'T YOU FOR ONCE MAKE USE OF GOOGLE Even Nigerian Medical Doctors are as ignorant as the Nigerians outside the Practice. I once had a debate with two Mdeical Doctors working in a Specialist Center, the result? They now have a broader perspective of things FOR 1.2 - 2.2 MILLION NAIRA, YOU CAN HAVE A CHILD, TWINS TRIPLETS AND EVEN QUADRUPLETS WHO ARE SICKLE-CELL FREE, IN JUST ONE SINGLE PGD PROCESS. THE REST OF THE EMBRYO FORMED CAN BE FROZEN FOR FUTURE USE Google "BOURNE PGD center", or MEDICAL ART CENTRE IKEJA, there are over 150 of such centers in the world today.
Stop deceiving yourselves with Permutations and Combinations. Oya, only the deep thinkers will appreciate this piece.

4 Likes

Re: Options Available For Same A.s Genotype Couple by doctorbabs(m): 10:43am On Jul 13, 2014
My candid advice to you my brother, Don't just try it or put your God into test. when the wahala start, or pastor we even deny you
Re: Options Available For Same A.s Genotype Couple by elnino3(m): 10:44am On Jul 13, 2014
IYANGBALI: you just dey jealous AA people because you be SS
no am not... am just being objective as per the op question. by the way am not ss, but then again what d u care
Re: Options Available For Same A.s Genotype Couple by Nwaobualor(m): 10:45am On Jul 13, 2014
All this love and lust wey dey push una to marry go clear wey u born ss kid for house. Two of una go trade blames tire n hate each other. I had such temptation 2 times with diff babes...tank God I no risk am. But why is it dt wen u ar "AS", na only "AS" good babes go dey cum ya way? That's y am stil single n serching at 35 cry

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Re: Options Available For Same A.s Genotype Couple by Genea(f): 10:53am On Jul 13, 2014
niceeric:
Bone marrow transplant na like 5k abi??.........this is Nigeria ooo,kidney transplant dey make whole family dey show for NTA dey beg for money let alone bone marrow transplant....prevention is way better and cheaper than cure!
lol
Re: Options Available For Same A.s Genotype Couple by vict505(m): 10:53am On Jul 13, 2014
bigmodo: What options are available for a couple with the same A.S genotype so they wont produce S.S children, please assist us.
Well there are some solutions and the two solution that are commonly use now are :- 1 through IVF an 2 Evacuating and testing method. The evacuating method is a process where by the couple will go for test to know if the baby that the wife is carrying is SS or AS and once the baby is SS they will Evacuate the pregnancy and that is what that will keep on doing till they have AS or AA cos they both have chances of 25% of AA and AS while they both have 50% chances of SS.

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Re: Options Available For Same A.s Genotype Couple by johnchiii(m): 11:05am On Jul 13, 2014
Mayour11: Pastors these days also advice that you shouldn't go into such relationship.


hahaha... interestinq..
Re: Options Available For Same A.s Genotype Couple by Oxone(m): 11:05am On Jul 13, 2014
The odds are 1/4 chance of AA, 1/2
chance of AS, 1/4 chance of SS.

Using IVF for implantation and then having a CVS (chorionic vilus sampling) to test for the genotype, its a little more complicated, but it will tell you which babies have which genotype. You can then choose to have any baby with the So Genotype terminated and leave healthy babies.

however, there is an obvious moral angle here because that would mean aborting the fetus with the SS Genotype. Some people consider it unethical but that's not what this topic is about and again it's all up to you.

CVS test itself has its own risks just like everything in life

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Re: Options Available For Same A.s Genotype Couple by Lexusgs430: 11:06am On Jul 13, 2014
If you are not yet married, I will advise against such union. There is a thin line between tempting faith and medical facts!!!!
Re: Options Available For Same A.s Genotype Couple by arsetalks(m): 11:06am On Jul 13, 2014
rutchiekens:

If the girl dies(no offence intended) wouldn't u move on. What u are feeling is just an emotion.
I am also AS and I understand deavicky well. I have been in that situation as well. And having found another girl who I truly love and who luckily happen to be AA and then had to return to the good LORD, I know for sure it is easier someone dying and you not marrying them than you having to break up with due to genotype.

It is difficult when someone dies and I would rather my angel lives than die but at least I do not have the fear of trying again which comes with having to dump someone cos of genotype.
Re: Options Available For Same A.s Genotype Couple by YoungDaNaval(m): 11:07am On Jul 13, 2014
aminho: i will have love to advise you but you know doctors are on strike wink wink
Hahahahahahahaha
Re: Options Available For Same A.s Genotype Couple by arsetalks(m): 11:09am On Jul 13, 2014
rutchiekens:

U're wrong,

u can't know just by looking at them.. Unless the parents are not taking care of the child very well.

The stats doesn't say 1 in 4.

I know someone whose first child is a sickler.

stop using stats cos that's gambling with a child's future.

You're living a healthy life so why would want a child to suffer.

U said your uncle bcame strained financially so I guess your reason is financial not out of selflessness.

Since u are not a sickler u'll never know/feel what your cousin felt.

Just so u know anyone can health problems so your reason should not be financial.
if I was selfish, I will marry another AS. Only someone mentally unstable will wish anyone else constant crisis. I am not selfish, one is allowed citing an example?
Re: Options Available For Same A.s Genotype Couple by Nobody: 11:12am On Jul 13, 2014
berem: I have seem most cases where the sickle cell children starts from the fourth child. Just from my observation though.

Happy sunday dear! smiley
lovely sunday! Hope you've talked to God today...
Re: Options Available For Same A.s Genotype Couple by Nobody: 11:14am On Jul 13, 2014
thankyouJesus:
It is also possible for none to be.
yeah, very possible. But the more the children, the more likely such couple will have a sickler.
Re: Options Available For Same A.s Genotype Couple by Nobody: 11:19am On Jul 13, 2014
Genea: My dear if you marry a As,u can do a bone marrow transplant if u av a SS as a child,am a medical student,i kno wat am saying and dere is a probability dat u can gv birth to ony one ss or none at all

you are disappointing Genea.... you call urself a med student and u advice such..... do u know wat it means to get a Stem cell donor match(not necessarily a bone marrow)...... most times, the couple still have to give birth to anoda child and the umbilical cord blood z used, DT new child could turn out to be SS too ,wat do u do den.... do u know how expensive it z.... do u know d failure rate keeping in mind DT d money z not refundable... I bet u r in ur preclinical years....so ur ignorance z pardoned
Re: Options Available For Same A.s Genotype Couple by donchrisk(m): 11:27am On Jul 13, 2014
No options
Re: Options Available For Same A.s Genotype Couple by emiye(m): 11:27am On Jul 13, 2014
berem: that's not possible unless they are not both AS.

i think it is possible, it is a game of chance. The chance that a pregnant woman will give birth to a boy is like 50%,likewise her chance of giving birth to a girl is 50%. but she might give birth to 7 girls consecutively.

The chance that two AS couples will not give birth to sicklers is 75%. Is the 25% risk worth taking? It is possible the two AS couples give birth to 4 SS children consecutively

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Re: Options Available For Same A.s Genotype Couple by Nobody: 11:31am On Jul 13, 2014
berem: If you are gonna have four kids,one of the kid is going to be a sickler. Two will be carriers and one normal:


AA AS AS SS

Its likely the fourth child will be the sickler but its not in all cases
Lol berem its not like DT....its per pregnancy, like probability.. during each pregnancy d probability of having an SS child is there (25% chance of SS, 50% chance of AS and 25%chance of AA) ..... I.e per pregnancy..... a marriage of DT sort can produce all SS children....... may not as well.... but walk into d Hosp DT cares for such children n Cee if u want to take dt risk..... don't tink d bone pains n sickness r d worst... der can suffer brain damage n become paralysed too...they can go blind too..... all as a result of vaso occlusion....op u understand
Re: Options Available For Same A.s Genotype Couple by blesoh(f): 11:43am On Jul 13, 2014
aminho: i will have love to advise you but you know doctors are on strike wink wink
lol,u bad oooh,so ur advice too its on strike.
Re: Options Available For Same A.s Genotype Couple by DECOtech(m): 12:01pm On Jul 13, 2014
Mynd44:
Why?

Isn't it funny that the same pastors that preach "Faith" and that "There is no situation that God can't change" are the ones writing this off? Is this a lack of Faith or a limitation of the abilities of "God"?

I believe God gave us the knowledge of medical science for our use and so we can make our lives better. He does not have to show up in our lives, he gave us knowledge so let's use it.

@OP,
IVF and/or Adoption

It is a lot better to have that and marry the person you love and you are happy with than leave that person and be miserable with the person you settle down with
Thou shall not tempt the Lord thy God.
Re: Options Available For Same A.s Genotype Couple by leverage(m): 12:07pm On Jul 13, 2014
Except you plan on not having children no love is worth bringing a child into this world to suffer abeg make una just jeje split the love won't even be there anymore if you born sickler which 1:4 of every pregnancy issue
Re: Options Available For Same A.s Genotype Couple by Nobody: 12:07pm On Jul 13, 2014
seems intending couples both carryn AS av no idea wat exactly sickle cell anemia is.

*Sickle cell anemia is an inherited form of
anemia — a condition in which there
aren't enough healthy red blood cells to
carry adequate oxygen throughout your
body.
* The major features of sickle cell anemia
include:
*Fatigue and Anemia
*Pain Crises
*Dactylitis (swelling and inflammation
of the hands and/or feet) and
Arthritis
*Bacterial Infections
*Splenic Sequestration (sudden
pooling of blood in the spleen) and
Liver Congestion
*Lung and Heart Injury
*Leg Ulcers
*Aseptic Necrosis and Bone Infarcts
(death of portions of bone)
*Eye Damage

if u are so selfish n want ur child to go through dese problems thinkn u b God junior broda dat he will be dere 4 u, u are free to get married. dont cry wen d symptoms start showing n u dnt av enof money.

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Re: Options Available For Same A.s Genotype Couple by holhuwaphemie: 12:10pm On Jul 13, 2014
Onlinebizexpert:

please for those already in this predicament and those who are trying to take the risk should listen tome

a medic reporting.......


first and foremost OP do not listen to people that are telling you to have faith in GOD because even GOD being so powerful instructed us as follows " Thou shall not TEMPT the LORD your GOD"" he is aware that one over zealous christian one day would jump from high tension cable and expect ANGELS to come and carry him to safety

it is also written that "HEAVEN helps those who help themselves" dont bother trying to risk it it is not worth it

even when the disciples were with JESUS, they still ate food why did'nt they have FAITH and GO HUNGRY.........it is called being LOGICAL

before anybody attacks me I AM A BIBLE BELIEVING CHRISTIAN

now to your question OP

from scientific calculations if two AS couple have intercourse they would have children with the following genotype
AA AS AS SS

though in some cases i have seen all the children were either AA or AS in some worst case scenario the children were all SS

the AA an AS children are not the problem , its the SS child whoma I PERSONALLY refer to as a VISA to HOSPITAL, POVERTY and MARRIAGE BREAK DOWN

VISA to HOSPITAL the SS child has set a record of always falling ill to the slightest provocation and most of these children do not live long, with this child the best thing is to relocate to a house near a hospital, THIS IS ONE REASON WHY AS AS marriage is seriously preached against

VISA TO POVERTY many people do not know that it takes about an average of 25,000 naira per week to manage an SS child, this amounts to about a 100,000 naira per month, imagine such an expense for a couple that has a salary of like 150,000 naira. just calculate 100,000 naira per month for like 10 years of marriage.. brethren that is poverty knocking at your door, this is another reason to avoid such marriages

VISA TO MARRIAGE BREAKDOWN: most marriages with SS child are always in turmoil, the LOVE is strained, everybody becomes angry at any provocation, each parent feels that it is the other persons fault that they are in this predicament, some even start cheating or considering SUICIDE.......this is why I personally advise people to enter a marriage that they might never enjoy

WHAT CAN I DO IN SUCH A MARRIAGE

adopt

ivf

stem cell transplant

prayer

ADOPT simply decide with your wife that your marriage is not for procreation rather it would be for companionship, the adopt a child/children and treat them the way you would have treated your own actual offspring... its not easy but its worth it

IVF in vitro fertilization, here your wife is fertilized with the sperm of a donor, the advantage of this is that you get to choose the characteristics of the donor that you wish to see in you child like tall, handsome, STRONG FACE grin etc.....

STEM CELL TRANSPLANT here your own child would undergo a process which can lead to genotype change...

NOTE: it is an expensive process and to be sincere i can vouch for nigeria as the best place to do this

PRAYER I am not telling you to pray to GOD to change your child's genotype, rather pray for things like GRACE,LOVE MONEY etc that will help you manage your family


WARNING for those about to enter such a marriage

1. na suffering get you
2. that LOVE that is making you not to be logical will fizzle out with years of suffering and then it will be too late to do anything

ANY PASTOR THAT IS ADVISING YOU TO ENTER SUCH A MARRIAGE IS SIMPLY TRYING TO USE YOU TO ENRICH HIS MINISTRY THROUGH YOUR TITHES AND PRAYER FACILITATING OFFERING


PERSONALLY, my GF is AS same as me, but we both know that it is not leading to the altar, I LOVE her very well and that is why I am not going to wed her into suffering and frustration

this should be the same for those yet to marry

I HOPE MY LITTLE EPISTLE WOULD HELP A FRIEND HERE......LOOKING FORWARD TO YOUR TESTIMONY


Speak little of that which u know not. Am a sickler and am sorry to tell u dat ur analysis here doesn't apply, u make it sound like an expensive death sentence. I live an absolutely normal life bro.

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