Jaykolo10:
That's the most wisest thing to do.. at least even the best knowledgeable thing to do..





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Benard94:


What is wisest and knowledgeable thing Mr.?

Jaykolo10:



Check your genotype before marriage Mr.

Benard94:


I am not talking about marriage... I mean accepting a proposal

Benard94:
A genotype is the entire genetic constitution of an individual, i.e. the genetic makeup of an organism or group of organisms with reference to a single trait, set of traits, or an entire complex of traits. In a nutshell: your genotype is your complete heritable genetic identity; the sum total of genes transmitted from parent to offspring.

There are four hemoglobin genotypes (hemoglobin pairs/formations) in humans: AA, AS, SS and AC (uncommon). SS and AC are the abnormal genotypes or the sickle cells . We all have a specific pair of these hemoglobin in our blood which we inherited from both parents.

The major issue with genotype match comes from the desk of the AS duos. Going ahead with it has been termed a risky gamble,while others have proved that they gave birth to no SS despite being AS.

The raging issue now is this.... Should one ask after the genotype before saying YES because of heartbreaks?
And how do one handle a loving partner with a genotype mismatch?

AA + AA = Excellent
AA + AS = Good
AA + SS = Fair
AS + AS = Bad
AS + SS = Very Bad
SS + SS = Extremely Bad (In fact, don’t try it)

Reasonable arguments please...

Seun:
If your genotype is AS or SS, you should know your partner’s genotype long before he even thinks about proposing to marry you. If your genotype is AA, then you have absolutely nothing to worry about. You can even marry someone with SS genotype; your children will be healthy but will have to watch who they marry.

Seun:
If your genotype is AS or SS, you should know your partner’s genotype long before he even thinks about proposing to marry you.

If your genotype is AA, then you have absolutely nothing to worry about. You can even marry someone with the SS genotype; your children will all be healthy with respect to this condition.

blackylola:
is AS and AC not the same

MissRaine69:


Hope this helps.
Genotype AA: At position 6 of both globin chains, the amino acid is GLUTAMATE

Genotype AS: At position 6 of one globin chain is GLUTAMATE and at position 6 of the second globin chain, you have VALINE

Genotype SS: At position 6 of both globin chains, the amino acid is VALINE

Genotype AC: At position 6 of one globin chain is GLUTAMATE and at position 6 of the second globin chain, you have LYSINE

blackylola:
is AS and AC not the same

MissRaine69:
If we are honest with ourselves this question should be posed way before the status of relationship is confirmed giving both parties choice .

Seun:
If your genotype is AS or SS, you should know your partner’s genotype long before he even thinks about proposing to marry you.

If your genotype is AA, then you have absolutely nothing to worry about. You can even marry someone with the SS genotype; your children will all be healthy with respect to this condition. They will even enjoy increased resistance to malaria.

Benard94:



All these 'I love you' that would have gone for a long time before discovering the duos are AS. Handling such could be hard... If we should even ask, how many people here know their genotype?

It's hard because people fall in love before thinking of genotype

MissRaine69:


If you see what I initially wrote ....” if we are honest” I am not oblivious to the fact that most allow the emotional mind to take over making decision making very difficult.
Before the “I love you’s” set in stone when you are still toying with the notion of is he or is she the one ask the most important question that will determine if children are a viable option or a huge risk.

Ejiod:
I would differ to some comments here about saying yes, the basic fear is that of getting sickle cell offspring. However with medical advancement like Chorionic villus sampling & amioncentesis I guess there's high chance preventing this genetic disorder if the 2 couples truly love each other. To me its only in Africa that we carry genotype on top our head.genetic engineering has a lot of answers to these issue.
Besides sickle cell is not the only genetic disorder, some may be carrying dominant
or recessive genetic disorders and they Dont know and they go and marry only for them to give birth to autistic, or down syndrome kids.
In summary I will go for YES so as to prevent what u can't bear

trustyshoess:

The reason why it's only in Africa that we carry this genotype issue on our head is because it's a well known fact that the AS genotype is almost exclusively found in Africans and those of African descent. Reason for this is that AS red blood cells are highly resistant to malaria which is a favoured trait in a continent where malaria is prevalent. People with rhis favoured trait therefore are more likely to survive and pass this on (so higher AS pop). However AS + AS could lead to SS, hence the need to know these things

PS, autism isn't genetic, It's a spectrum disorder and neither is down syndrome which is caused by an extra chromosome

Ejiod:

Dear, u can check this link. Its Wikipedia
https://en.m.wikipedia.org/wiki/Heritability_of_autism.
Meanwhile I still have many article from ncbi showing those disorders I mentioned as genetic. Research has gone far dear

Ejiod:
I would differ to some comments here about saying yes, the basic fear is that of getting sickle cell offspring. However with medical advancement like Chorionic villus sampling & amioncentesis I guess there's high chance preventing this genetic disorder if the 2 couples truly love each other. To me its only in Africa that we carry genotype on top our head.genetic engineering has a lot of answers to these issue.
Besides sickle cell is not the only genetic disorder, some may be carrying dominant
or recessive genetic disorders and they Dont know and they go and marry only for them to give birth to autistic, or down syndrome kids.
In summary I will go for YES so as to prevent what u can't bear

trustyshoess:

Okay maybe I wasn't clear enough. Autism and Downs syndrome are indeed genetic disorders because they are caused by faulty genes. However, what I meant to relay earlier was that they are not hereditary, therefore they aren't passed on from parents to children. It is even highly unlikely that a downs patient could have children as most are infertile.
It is true tho, that the conditions could be spotted during early pregnancy through genetic tests on the embryo

Ejiod:
I would differ to some comments here about saying yes, the basic fear is that of getting sickle cell offspring. However with medical advancement like Chorionic villus sampling & amioncentesis I guess there's high chance preventing this genetic disorder if the 2 couples truly love each other. To me its only in Africa that we carry genotype on top our head.genetic engineering has a lot of answers to these issue.
Besides sickle cell is not the only genetic disorder, some may be carrying dominant
or recessive genetic disorders and they Dont know and they go and marry only for them to give birth to autistic, or down syndrome kids.
In summary I will go for YES so as to prevent what u can't bear

trustyshoess:
The answer doesn't have to be "no" if they other person is a mismatch (i.e AS + AS) as there are ways to get around it but it's always important to know these things to prevent the possible disaster that could ensue

Benard94:



U mean AS+AS can work it out? How?

trustyshoess:
The answer doesn't have to be "no" if they other person is a mismatch (i.e AS + AS) as there are ways to get around it but it's always important to know these things to prevent the possible disaster that could ensue

tunize:

So what are the ways to get around it??