₦airaland Forum

Rich4god: B like you wan chop cane... Mumsi... Increase am to 50 lashes...

Sure Son.. Sure he deserves it

FrancisTony: Because of this kiss?

Kiss ke? I mean asking me to teach

FrancisTony please stop exposing me that side, I beg of you

FrancisTony: LOL! You are funny. You can make a good english teacher jor.

If you say so

FrancisTony: LOL! Even CRS and English sef.

Hmm CRS, maybe,... English I can only pray for mercy on my students because they will likely score G10 parallel

dagr8: Thanks dear, I get it . Common sensically, I see it is the same explanation done with the predominant three.
In summary, one should avoid a situation where HbS can meet with another HbS to produce SS off spring, right?

Hmm,SC not as bad but bad right? Not much stress but at least stress involve,right? Better than SS but not the best, I think that one too should be discouraged


Do you believe prayer can change all these things? I may not need to run you know

Lol you got me laughing now

Yea every haemoglobinopathy has slight stress attached to it but non is as bad as HbSS, normally i would say to discourage it, but when these would-be couple start bombarding you with how they can't do without each other eh smh
The ish is that most SCs don't usually experience crisis and for their PCV, that can be taken care of by proper dietary and frequent intake of blood building substances



And ah, as for prayer changing all things, I believe in miracles but it's against the ethics of my profession to encourage what it discourages because of my personal believe,

FrancisTony: Hmmn. You'll make a good biology/chemistry teacher.

Teacher ke? Maybe but am not sure I will try that so as not to breakdown

yetseyi: Owkie just wanted to ask. i saw your post on the HbASC last year I think. I had expected that thread to grow but it didnt. kindly explain please
I have also heared of the Hb D,E stuff.
Also i just googled now and saw something on Ab genotype.
Anyway all is well

Yes the HbASC is a rare one which even 90% of lab scientists and doctors don't even know of it's existence, I remember the first time I got that result, (the first in the history of our hospital) not a single person in the entire hospital knew of it everyone was like "Sal, there must be a mistake somewhere"

Anyway till date we are yet to have a generally accepted explanation to it but we know it's there because we've seen atleast four of those, other hospitals too are beginning to see it.

Well when we sent it to the council seeking for clarification, ( sorry for our country that can't provide funds for proper research) we got two possible causes .....

Let me dangle a little into explaining the causes of HbS and HbC for a better understanding

When a child is born, he has two major globin chains, ie alpha and gamar chains, this is known as HbF ( fetal haemoglobin) at least six months and above of the child's birth, the garma chain begins to metamorphosize into Beta chain and we begin to represent this as HbA (adult haemoglobin) at this stage you can easily conduct genotype test for the baby.

On this beta chain, we have continuously the glutamic acid as the normal amino acid that make up this chain. Now if by chance another amino acid replace any of this G.A at any position, it gives rise to what we call haemoglobinopathy or haemoglobin variant.

If the amino acid Valine replaces glutamic acid in the sixth position on the beta globin chain, it leads to sickling, giving the RBC and S shape with low oxygen affinity ... This is what is referred to as HbS.

If it happens that on thesame position 6 the amino acid Lysine is the one replacing the glutamic acid instead of valine, we have HbC instead of HbS.
If Lysine replaces G.A in position 26 we have HbE
If lysine replaces G.A in position 121, we have HbO etc etc
Now the major problem in HbASC is that the replacement that gives rise to both takes place on thesame position 6. On the beta chain. While the amino acids that replaces to give rise to each differs. Ie Valine and Lysine
Note also that in a person's body, there are numerous beta globin chains not just one.

Now the question is ... Could it be that both Lysine and valine forcefully replace the G.A. on the sixth position in every beta globiin chain or does it mean that in a persons' system, lysine replaced glutamic acid in position 6 of some of these numerous beta globin chains while valine replaces glutamic acid on others?
The answer so far revolves around these two possibilities with the later being better favoured but none is proved yet.

That's the little I can say till further proof is produced.

Note- presently there is a machine that is capable of detecting a newborn's genotype as early as three days after birth. (That's btw)
I hope this helps.

dagr8: Lol...I thought there are only three genotypes(AA, AS, SS).
So, how would you explain "these genotypes can marry"-thing, with AC, SC, CC and ASC genotypes? (hope you get my question)

Lol.... No, those three are the most commonly seen, again I have to note that most people at least here in Nigeria who think they are AS are actually AC. That aside let me answer your question.

AA + AA =YES
AA +AS =Yes
AA +SS =Yes
AA +AC=Yes
AA +CC=Yes Infact AA can marry any genotype at all

But
AS +AS=No
AS +AC =Possible, the worst they can produce is SC while SC is not as bad because HbC doesn't pose much stress such a person will only have low to low-normal haemoglobin. Therefore won't require much transfusion since the half life of the RBC in HbC is 32day. It is better compared to HbSS inn the sense that it has a slightly higher oxygen affinity

To cut the story short, the only ones that are strictly discouraged are the one which are likely to produce SS off springs. Others aren't So bad and can easily be managed and the mortality rate is relatively low.

So if you are AA go on and marry anyone but once you have the presence of HbS in you, run as fast as you can from anyone who equally has HbS.

dagr8: Hmmm, the Spirit took you there?

Probably

Serious

yetseyi: Good morning
Anything like genotype AB not blood group,
or better still a result like Genotype AB blood group Bplus in an african .

Strictly speaking, in accordance with manifested physical trait, I will say NO, at least non that I've seen, heard or read of. When you hear of genotype AB, the said person might be referring to "the genetic makeup" which when duly analysed, is taking about the ABO system.

Let me not confuse you now, what am saying is this.. You cannot go to the lab for genotype test and the result given to you reads thus.. Genotype-AB or Genotype-HbAB as the scientist deems fit to present the result.

The possible genotypes you can find here are.. AA, AS, AC, SS, SC, CC, and ASC.

There are also haemoglobin D and E but they are rarely found in Africa, therefore don't be surprised to hear of genotype AD, AE,DE, CD etc etc but I never heard of haemoglobin B therefore the possibility of have B included in any genotype is almost 0. Except the scientist wants to present us with a new discovery

But the B+ blood group is very possible.

dagr8: Ayam fine Sallie...where were you before on Friday

Thank God
I was in the valley of dry bones.....

yetseyi: Sal C you are a lab scientist right

Yes dear, Good morning...

jnrbayano: I pray

Pray harder, speak in tongues too

Good morning brethren do have a blessed day ahead

beejaay: the guy don jump class from one wrap to 5 wraps a day

SMH

jacobscros: I have had an awakening of the holy spirit in me. This has led me to understand the bible very easily now and prophesy at will. The rapture is so near its frightening how many people are still asleep spiritually. My advice to all is to pray psalm 51vs 10

jnrbayano: Easier said.

I miss her too nonetheless

I trust you know what I can do

jnrbayano: How I wish I know what you are talking about

Don't worry you will soon get to know

Rich4god: lol.... The items should be with her elders na... So it didnt get missing in our hands...

Yes I know, but it would have been better to have it here as evidence.

jnrbayano: Looking for thy ally?

Actually I alone can handle you, just that I miss her

jnrbayano:

Aren't you beautiful? Btw I liked you guys pixs the two certified beautiful guys here

dagr8: Where is Sal C.....NL is back for posting on a Friday ....

Mehn it's not funny. Btw how are you?

hurricaneChris: Unbelievable! They really hit nairaland badly. #Amnesia

True talk bro...

jnrbayano:

Beautiful man

Rich4god: My zing will be back soon... Have already mailed her...

That's thoughtful of you, I can't believe we lost all those items we took to her village to marry her

Rich4god: Will get it fixed... Just matter of time...

That will be cool....