I noticed that I HV been feeling dizzy,cold and light headed for days/I ran lab tests and the result showed that d malaria is scanty..while d typhoid is not significant.d doctor advised I rest well.that d results are not serious enough to place me on drugs.Am not getting any better..pls,doctors in the house,what should I do ?

Blackbeauty: I noticed that I HV been feeling dizzy,cold and light headed for days/I ran lab tests and the result showed that d malaria is scanty..while d typhoid is not significant.d doctor advised I rest well.that d results are not serious enough to place me on drugs.Am not getting any better..pls,doctors in the house,what should I do ?

seek second opinion. see another doctor.

My friend go n tek antimalarials; as a rule in medical practise; u treat patients not test results!!!

You did not see a doctor, you saw a quack. Malaria does not just "go away" with no treatment. If you are bitten by the P. falciparum mosquito you can face death. The P.ovale P.vivax are not as capable of causing death but it is not smart to be hosting malaria parasites in your liver and blood for any period of time. Did he even tell you which species of parasites are multiplying in your blood Go buy some Arthemeter and lumefantrine for falciparum infestation and don't fool around. Parasites can get a good foothold in your liver and cause recurring fevers. Go to a reliable clinic for a proper blood test and identify the mosquito then get the proper medicine. Take iron tablets and b vitamins to fortify your blood. Malaria will debilitate you over time.

Ekundayo7: You did not see a doctor, you saw a quack. Malaria does not just "go away" with no treatment. If you are bitten by the P. falciparum mosquito you can face death. The P.ovale P.vivax are not as capable of causing death but it is not smart to be hosting malaria parasites in your liver and blood for any period of time. Did he even tell you which species of parasites are multiplying in your blood Go buy some Arthemeter and lumefantrine for falciparum infestation and don't fool around. Parasites can get a good foothold in your liver and cause recurring fevers. Go to a reliable clinic for a proper blood test and identify the mosquito then get the proper medicine. Take iron tablets and b vitamins to fortify your blood. Malaria will debilitate you over time.

Iron tablets and vitamins I'm sure u meant multivitamins wit A+L drugs!!! Jesus!!! I hope u r nt a doctor/pharmacist because u wud ve known abt some drug interactions

bigblangston: Iron tablets and vitamins I'm sure u meant multivitamins wit A+L drugs!!! Jesus!!! I hope u r nt a doctor/pharmacist because u wud ve known abt some drug interactions

Did you even read the post?? 1. find out which parasite 2. if falciparum, IN MY EXPERIENCE, Arthemeter Lumefantrine is best, 3. the need to pump up the blood hence iron tablet, A MINERAL, DUH, and B vitamins. Do you even know what "B" vitamins are? If he has typhoid, that "doctor" should lose his license. By not treating he is allowing the op to walk around spreading typhoid to others. Nigeria....smh

Ekundayo7:
Did you even read the post?? 1. find out which parasite 2. if falciparum, IN MY EXPERIENCE, Arthemeter Lumefantrine is best, 3. the need to pump up the blood hence iron tablet, A MINERAL, DUH, and B vitamins. Do you even know what "B" vitamins are? If he has typhoid, that "doctor" should lose his license. By not treating he is allowing the op to walk around spreading typhoid to others. Nigeria....smh

Boss!!! It's patently obvious u don't knw wat u r sayin.... Iron interacts wit anti malaria drugs.

bigblangston: Boss!!! It's patently obvious u don't knw wat u r sayin.... Iron interacts wit anti malaria drugs.

Oh Gosh! I guess that's why every frickin doctor I've been to in Nigeria prescribes IRON and B Vitamins when you have malaria and typhoid, right? Mumu.

Ekundayo7:
Oh Gosh! I guess that's why every frickin doctor I've been to in Nigeria prescribes IRON and B Vitamins when you have malaria and typhoid, right? Mumu.

bros! Respect ur hard earned old age,neva knew u ve gone to every doctor in nigeria seekin 4 medical help,quit insultin me because u may nt knw hw it will end 4 u, No wonder dey said ignorance is bliss

bigblangston: bros! Respect ur hard earned old age,neva knew u ve gone to every doctor in nigeria seekin 4 medical help,quit insultin me because u may nt knw hw it will end 4 u, No wonder dey said ignorance is bliss

BWAHAHAHAHAHA! Empty threat is all you got?

Ekundayo7:
BWAHAHAHAHAHA! Empty threat is all you got?

Try me... And 4 d records I don't threaten d weak

bigblangston: Try me... And 4 d records I don't threaten d weak

Trust me, you don't want to mess with me or my Esu sha.

There's absolutely no need for the fight. Generally, artemether/lumefantrine works by generating free radicals. Anything that acts against the radicals are not wanted until after completion of the ACT regimen.

Ekundayo7:
Trust me, you don't want to mess with me or my Esu sha.

V.funny

y d fight na, pls behave like gentlemen, actually multivitamins interact wit artemeter/lumenfantrine, it reduces d effect of d drug, bt at d sametime, u need to fortify ur blood while taking antimalaria because d drugs fight against d parasite some of which are in d blood cells, hence we encourage patients to take multivitamins after completing antimalaria drugs...ds from my little experience few yrs post induction, I believe my elders in medicine can expantiate more. ., moreover, i hope d Op isnt pregnant, ds cld be d reason y d doc encouraged u not to treat d malaria esp in early pregnancy, also sometime I dont reckon wit widal reaction because it crossreacts wit malaria infection, so u may actually not av typhoid for all I care...goodluck to u sha

megaf1: y d fight na, pls behave like gentlemen, actually multivitamins interact wit artemeter/lumenfantrine, it reduces d effect of d drug, bt at d sametime, u need to fortify ur blood while taking antimalaria because d drugs fight against d parasite some of which are in d blood cells, hence we encourage patients to take multivitamins after completing antimalaria drugs...ds from my little experience few yrs post induction, I believe my elders in medicine can expantiate more. ., moreover, i hope d Op isnt pregnant, ds cld be d reason y d doc encouraged u not to treat d malaria esp in early pregnancy, also sometime I dont reckon wit widal reaction because it crossreacts wit malaria infection, so u may actually not av typhoid for all I care...goodluck to u sha

thank u maam 4 ur write up, dat wat was I was tryin to tell dat young man abt some drug interactions bt in other not to be corrected he had to resort to insults.

Ekundayo7: You did not see a doctor, you saw a quack. Malaria does not just "go away" with no treatment. If you are bitten by the P. falciparum mosquito you can face death. The P.ovale P.vivax are not as capable of causing death but it is not smart to be hosting malaria parasites in your liver and blood for any period of time. Did he even tell you which species of parasites are multiplying in your blood Go buy some Arthemeter and lumefantrine for falciparum infestation and don't fool around. Parasites can get a good foothold in your liver and cause recurring fevers. Go to a reliable clinic for a proper blood test and identify the mosquito then get the proper medicine. Take iron tablets and b vitamins to fortify your blood. Malaria will debilitate you over time.

You are talking sense, abeg how malaria dey take get foothold on the liver and how I go know which mosquito. Because, my own malaria too much...na every three wks e dey show for the past decade. The worst is that all those big malaria medicines no dey work for my body. Na only chloroquine and amalar dey work.

megaf1: y d fight na, pls behave like gentlemen, actually multivitamins interact wit artemeter/lumenfantrine, it reduces d effect of d drug, bt at d sametime, u need to fortify ur blood while taking antimalaria because d drugs fight against d parasite some of which are in d blood cells, hence we encourage patients to take multivitamins after completing antimalaria drugs...ds from my little experience few yrs post induction, I believe my elders in medicine can expantiate more. ., moreover, i hope d Op isnt pregnant, ds cld be d reason y d doc encouraged u not to treat d malaria esp in early pregnancy, also sometime I dont reckon wit widal reaction because it crossreacts wit malaria infection, so u may actually not av typhoid for all I care...goodluck to u sha

in as much as I reckon with ur inciteful write up; it is worthy of note; daat in clinical medicine; most drugs interract; wwhat u actually tek into consideration; is "is it a significant interaction" to mek u pause or change course? Dat should be what u ask urself; n for the records; ACT n M/Vites reaction re not significant enof; to want to stop d haematinics n M/vites, dat 'll be strictly silly; do not forget; malaria on its own causes haemolysis (bld breakdown) plus, artemisinins n lume; are blood schizonticides; so in a way they could also induce haemolysis , + things like vit C are also anti oxidants, n help mopp up free radicals; dat could be generated...
So in summary; they can go!!! It is not an "out of order" practise... Tnx ... Y'aall

mecussey:

You are talking sense, abeg how malaria dey take get foothold on the liver and how I go know which mosquito. Because, my own malaria too much...na every three wks e dey show for the past decade. The worst is that all those big malaria medicines no dey work for my body. Na only chloroquine and amalar dey work.

You really need to find a good doctor or clinic who can show you WHICH form of parasite you have in the blood and that shouldn't be too hard. If it is p vivax or p.ovale they can go into a "dormant" liver stage and then reenter the blood at any time IF you have not been treated properly, causing symptoms again. Primaquine is usually indicated but since naija mosquitos are on steroids you really need to find a competent doctor to help you. I have had malaria so many times is why I am trying to help you, and I had to figure it our for myself in the end as doctors were not treating it properly unfortunately. I put together a few paragraphs here that might help you. MAIN THING is make sure you are not simply being reinfected from being bitten. Are you sleeping with a mosquito net? (which is necessary). Long pants if out at night or avoiding areas with infestations? If you are not being bitten and sleeping under net than I suspect you have an old vivax or ovale infection that was simply not treated for long enough or with the right drugs. If you are in Lagos Agboju side there is a good clinic there, let me know if you are close that side and I will try and get the address for you.

Malaria would have been a simple problem if not for its habit of recurring again and again and again. I have seen patients who have had malarial attacks 35-40 times in 3-4 years period. It is this problem which also keeps the disease alive in a community and makes its control quite difficult.

Why does malaria recur?

Following are the reasons for recurrence of malarial attacks:

1. Absence of effective immune response: Immune response against malarial infection is very poor and it does not protect against re-infections. Acquired immunity develops after several attacks of malaria over several years. This immunity is stage specific, species specific and 'strain' specific. It does not have any sterilizing effect on the parasitemia and immune adults are still re-infected. However, the clinical signs and symptoms are reduced with development of clinical immunity.

Various explanations have been offered for these observations. Generalised immunosuppression by the parasite; presence of T-cell independent antigens which fail to induce immune response; inhibition of B-cell proliferation; and extreme polymorphism or clonal variation of immunologically relevant antigens could be the causes for the poor immune response in malaria.

2. Exposure to repeated mosquito bites and re-infection: The commonest cause for recurrence of malaria is re-infection. The patient is exposed to fresh mosquito bites soon after completing the anti malarial treatment. On the one hand he has no immunity from the past infection and on the other, the antimalarials do not prevent establishment of the fresh infection. Therefore, unless the patient observes stringent anti mosquito measures, re-infection is inevitable in an endemic area.

3. Incomplete treatment: All blood schizonticidal drugs suppress the erythrocytic schizogony and give symptomatic relief. The patient may stop the drugs due to various reasons like vomiting, ignorance and financial constraints. This results in recrudescence within a short period. Also, if the patient does not take the complete course of primaquine, relapses can occur from re-activation of hypnozoites in the liver.

Proper patient education regarding the complete course of anti malarials is very important.

4. Relapse: In cases of P. vivax and P. ovale infections, recurrent attacks could be due to re-activation of hypnozoites in the liver. This can occur any time after 30-180 days of the primary attack. The relapses have the characteristic symptoms of malaria. Splenomegaly may be a prominent feature in these patients.

Such long-term relapses commonly occur in patients who have either not taken primaquine or taken incomplete treatment.

5. Recrudescence: In P. falciparum and P. malariae infections, the parasites can remain in the blood for months or even years and cause recurrent symptoms from time to time. In falciparum malaria, such recrudescence can occur within 28 days of the primary attack and may indicate partial resistance to chloroquine. However, treating every case of recurrent P. falciparum as resistant malaria is unjustified. One should consider the possibility of re-infection in most of these cases. Orht et al have studied the recrudescent isolates by PCR genotyping and have concluded that PCR genotyping could be a practical method of distinguishing recrudescence from re-infection.

It is a common observation that in a household, only some members get recurrent attacks of malaria while the others escape the infection. In such cases, it is important to find the cause for this phenomenon. The person may be getting bitten by the mosquitoes elsewhere, may be at his/her workplace. The resting and sleeping habits of such individual may be facilitating mosquito bites. Or else, any of the causes listed above may also be playing a role.

Malaria parasite and typhoid bacteria interfere with the liver and its functions. The invasion of the liver cells by malaria parasite and typhoid bacterium can cause organ congestion, sinusoidal blockage and cellular inflammation (Jarike et al., 2002; Petit and Wamola, 1994). When these happen, the parenchyma transaminases and membranous alkaline phosphatase and gamma glutamyl transpeptidase enzymes of the liver leak out and find their way into the circulation, leading to increased enzyme activity (Burtis et al., 2001). The liver is enlarged during the early stage in malaria infection and it is affected during the second week of infection of typhoid fever where the bacteria causes the inflammation of the liver. Untreated malaria and typhoid fever can lead to damage of the liver.
http://www.scialert.net/fulltext/?doi=pjbs.2014.860.863

Ekundayo7:
You really need to find a good doctor or clinic who can show you WHICH form of parasite you have in the blood and that shouldn't be too hard. If it is p vivax or p.ovale they can go into a "dormant" liver stage and then reenter the blood at any time IF you have not been treated properly, causing symptoms again. Primaquine is usually indicated but since naija mosquitos are on steroids you really need to find a competent doctor to help you. I have had malaria so many times is why I am trying to help you, and I had to figure it our for myself in the end as doctors were not treating it properly unfortunately. I put together a few paragraphs here that might help you. MAIN THING is make sure you are not simply being reinfected from being bitten. Are you sleeping with a mosquito net? (which is necessary). Long pants if out at night or avoiding areas with infestations? If you are not being bitten and sleeping under net than I suspect you have an old vivax or ovale infection that was simply not treated for long enough or with the right drugs. If you are in Lagos Agboju side there is a good clinic there, let me know if you are close that side and I will try and get the address for you.

Malaria would have been a simple problem if not for its habit of recurring again and again and again. I have seen patients who have had malarial attacks 35-40 times in 3-4 years period. It is this problem which also keeps the disease alive in a community and makes its control quite difficult.

Why does malaria recur?

Following are the reasons for recurrence of malarial attacks:

1. Absence of effective immune response: Immune response against malarial infection is very poor and it does not protect against re-infections. Acquired immunity develops after several attacks of malaria over several years. This immunity is stage specific, species specific and 'strain' specific. It does not have any sterilizing effect on the parasitemia and immune adults are still re-infected. However, the clinical signs and symptoms are reduced with development of clinical immunity.

Various explanations have been offered for these observations. Generalised immunosuppression by the parasite; presence of T-cell independent antigens which fail to induce immune response; inhibition of B-cell proliferation; and extreme polymorphism or clonal variation of immunologically relevant antigens could be the causes for the poor immune response in malaria.

2. Exposure to repeated mosquito bites and re-infection: The commonest cause for recurrence of malaria is re-infection. The patient is exposed to fresh mosquito bites soon after completing the anti malarial treatment. On the one hand he has no immunity from the past infection and on the other, the antimalarials do not prevent establishment of the fresh infection. Therefore, unless the patient observes stringent anti mosquito measures, re-infection is inevitable in an endemic area.

3. Incomplete treatment: All blood schizonticidal drugs suppress the erythrocytic schizogony and give symptomatic relief. The patient may stop the drugs due to various reasons like vomiting, ignorance and financial constraints. This results in recrudescence within a short period. Also, if the patient does not take the complete course of primaquine, relapses can occur from re-activation of hypnozoites in the liver.

Proper patient education regarding the complete course of anti malarials is very important.

4. Relapse: In cases of P. vivax and P. ovale infections, recurrent attacks could be due to re-activation of hypnozoites in the liver. This can occur any time after 30-180 days of the primary attack. The relapses have the characteristic symptoms of malaria. Splenomegaly may be a prominent feature in these patients.

Such long-term relapses commonly occur in patients who have either not taken primaquine or taken incomplete treatment.

5. Recrudescence: In P. falciparum and P. malariae infections, the parasites can remain in the blood for months or even years and cause recurrent symptoms from time to time. In falciparum malaria, such recrudescence can occur within 28 days of the primary attack and may indicate partial resistance to chloroquine. However, treating every case of recurrent P. falciparum as resistant malaria is unjustified. One should consider the possibility of re-infection in most of these cases. Orht et al have studied the recrudescent isolates by PCR genotyping and have concluded that PCR genotyping could be a practical method of distinguishing recrudescence from re-infection.

It is a common observation that in a household, only some members get recurrent attacks of malaria while the others escape the infection. In such cases, it is important to find the cause for this phenomenon. The person may be getting bitten by the mosquitoes elsewhere, may be at his/her workplace. The resting and sleeping habits of such individual may be facilitating mosquito bites. Or else, any of the causes listed above may also be playing a role.

Malaria parasite and typhoid bacteria interfere with the liver and its functions. The invasion of the liver cells by malaria parasite and typhoid bacterium can cause organ congestion, sinusoidal blockage and cellular inflammation (Jarike et al., 2002; Petit and Wamola, 1994). When these happen, the parenchyma transaminases and membranous alkaline phosphatase and gamma glutamyl transpeptidase enzymes of the liver leak out and find their way into the circulation, leading to increased enzyme activity (Burtis et al., 2001). The . Untreated malaria and typhoid fever can lead to damage of the liver.
http://www.scialert.net/fulltext/?doi=pjbs.2014.860.863

I am tired of doctors protocols, are u suggesting I try Primaquine? Again, I add weight whenever i am down with the malaria I guess it's a kind of liver inflamation right?

View the complete list of approved drugs that cure malaria from here http://www.edumacro.com/malaria-treatment-prevention/

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