Weizmann Institute study finds molecule prevalent in embryonic cardiac tissue promotes rapid healing in adult mice, as well as in human cells

israeli scientists have isolated a molecule that promotes heart cell regeneration, according to the results of a new study published in Nature magazine, a discovery that could offer hope to millions of sufferers of cardiovascular diseases around the world.

The study, led by Rehovot’s Weizmann Institute of Science in cooperation with several other schools in Israel and in the US, examined the effect of an embryonic protein on adult heart regeneration.

While heart regeneration in mammals has been observed during the prenatal stage, it is virtually impossible for the blood-pumping organ to heal after birth. Any damage to the heart from that point on, through heart attacks or other maladies, is there to stay.

Even worse, the healthy heart muscle cells, or cardiomyocytes, are replaced by scar tissue that places further burden on the remaining healthy cells.

Thus, any damage to the heart only increases the risk of further degeneration and eventual failure.

Researchers studied a protein called Agrin, common in fetal hearts, which rapidly disappears after birth. They now believe Agrin, which resides in the space between prenatal heart cells, controls the process of cardiomyocyte regeneration.

The scientists extracted Agrin from the hearts of newborn mice, which retain the protein for about a week after birth, and tested it in various environments, to highly encouraging results.

When tested in lab cultures, Agrin was seen to promote cardiomyocyte growth in the tissue of adult hearts — both mice and human.

And when injected into the damaged hearts of live mice, Agrin appeared to heal them and restore them to regular working order within weeks, greatly reducing scar tissue and replacing it with new healthy muscle cells.

“Clearly this molecule sets a chain of events in motion,” Prof. Eldad Tzahor of the Weizmann Institute said.

http://www.timesofisrael.com/israeli-scientists-successfully-regenerate-damaged-hearts/

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cristianisraeli:
Imagine the progress Israel could give to the world if they didn't have to spend so much energy on defending themselves from the anti-semetic policies and actions of the world and living with terror everyday of their lives..long live the state of israel

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See what other nations are doing while we are here guessing Buhari's location and status.

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Destined2win:
When I become President, I will be friends with Israel for very obvious reasons. I know some people will not like it but at the end, the means will be justified.

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mods will never push this to front page