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New Research Opens The Door To 'functional Cure' For HIV - Health - Nairaland

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New Research Opens The Door To 'functional Cure' For HIV by Enouwem(m): 9:08pm On Oct 17

The authors of the new study included (left to right): Susana Valente, Cari F. Kessing and Chuan Li. Credit: The Scripps Research Institute

In findings that open the door to a completely different approach to curing HIV infections, scientists from the Florida campus of The Scripps Research Institute (TSRI) have for the first time shown that a novel compound effectively suppresses production of the virus in chronically infected cells, and prevents viral rebound, even when those infected cells are subjected to vigorous stimulation.

The study, led by TSRI Associate Professor Susana Valente, was published online Oct. 17 before print in the journal Cell Reports.

"No other anti-retroviral used in the clinic today is able to completely suppress viral production in infected cells in vivo," Valente said. "When combining this drug with the standard cocktail of anti-retrovirals used to suppress infection in humanized mouse models of HIV-1 infection, our study found a drastic reduction in virus RNA present—it is really the proof-of-concept for a 'functional cure.'"

Valente, a pioneer in this new approach, calls it "Block-and-Lock"—the approach blocks reactivation of the virus in cells, even during treatment interruptions, and locks HIV into durable state of latency.

Valente and her colleagues use a derivative of a natural compound called didehydro-Cortistatin A (dCA), which blocks replication in HIV-infected cells by inhibiting the viral transcriptional activator, called Tat, halting viral production, reactivation and replenishment of the latent viral reservoir.

"Combining dCA with anti-retroviral therapy accelerates HIV-1 suppression and prevents viral rebound after treatment interruption, even during strong cellular activation," Valente said. "It's important to note that our study uses the maximum tolerable dose of the drug—with virtually no side effects."

The scientists studied the combination therapy in a mouse model of HIV latency and persistence. Once the combined treatment regimen was halted, viral rebound was delayed up to 19 days, compared with just seven days in mouse models receiving only anti-retroviral treatment.

"This demonstrates the potential of 'block-and-lock' strategies," said TSRI Research Associate Cari F. Kessing, co-first author of the study. "This study shows that a 'functional cure' approach can succeed in reducing residual virus in the blood during anti-retroviral treatment and limiting viral rebound during treatment interruption."

"In half of the dCA treated mice, the virus was undetectable for 16 days after all treatment was halted," said the University of North Carolina's Christopher Nixon, another first author.

"We blocked Tat, and the cell's machinery did the rest," said TSRI Research Associate Chuan Li, a coauthor of the study. "The result was that the HIV promoter becomes repressed."

Valente pointed out that the animal models were exposed to just a single month of treatment. "That's a relatively short period of time," she said. "We think longer treatments will result in longer, or even permanent, rebound delays. The question is how long? We're studying that now."

Because any viral rebound of HIV comes with a host of adverse effects, Valente noted, blocking that rebound would automatically reduce those effects.

"This is the only class of drugs that stops infected cells from making viruses outright," said Valente. "All current antivirals work later in the viral lifecycle, so only a HIV transcriptional inhibitor like dCA can stop the side effects of low-level virus production."

In addition to Valente, Kessing, Li and Nixon, other authors of the study, "In Vivo Suppression Of HIV Rebound By Didehydro-1 Cortistatin A, A 'Block-And-Lock' Strategy For HIV-1 Treatment," are Guillaume Mousseau and Mohammad Fallahi of TSRI; Perry M. Tsai, Phong T. Ho, Jenna B. Honeycutt and J. Victor Garcia of the University of North Carolina; and Hiroshi Takata and Lydie Trautmann of Walter Reed Army Institute of Research and the Henry M. Jackson Foundation for the Advancement of Military Medicine.

Source: https://m.medicalxpress.com/news/2017-10-door-functional-hiv.html

Lalasticlala

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Re: New Research Opens The Door To 'functional Cure' For HIV by Kimy97(f): 9:56am On Oct 18
Hmmmm..good...Ftc Tinx

1 Like

Re: New Research Opens The Door To 'functional Cure' For HIV by Ihatepork: 9:56am On Oct 18
good
Re: New Research Opens The Door To 'functional Cure' For HIV by JoshMedia(m): 9:56am On Oct 18
Nice one
Hope it turns to be successful.



Check my signature
Re: New Research Opens The Door To 'functional Cure' For HIV by dycbk: 9:56am On Oct 18
FTC YAHHO
Re: New Research Opens The Door To 'functional Cure' For HIV by BornnAgainChild(f): 9:56am On Oct 18
Ok good...but what about monkey pox

3 Likes

Re: New Research Opens The Door To 'functional Cure' For HIV by Celcius: 9:56am On Oct 18
We hope for a final cure.
A longer time for the Virus to stay repressed is a welcome development.

2 Likes

Re: New Research Opens The Door To 'functional Cure' For HIV by donblade85555(m): 9:57am On Oct 18
Since they gave birth to me that they being researching about this HIV....there already have the cure but they want us to keep eating money on that their HIV control drug.

anyway for funny jokes and riddles that will make you laugh like a mad man visit www.laughkillme.com

1 Like

Re: New Research Opens The Door To 'functional Cure' For HIV by ivolt: 9:57am On Oct 18
This isn't a cure per se, just an improvement on existing ARVs.

3 Likes

Re: New Research Opens The Door To 'functional Cure' For HIV by Hawlahscho(m): 9:58am On Oct 18
Re: New Research Opens The Door To 'functional Cure' For HIV by stcool(m): 9:58am On Oct 18
mccoy47:
Team Raw!
Time to go powered! !

You need Jesus!

10 Likes 1 Share

Re: New Research Opens The Door To 'functional Cure' For HIV by saint047(m): 9:58am On Oct 18
Ok
Re: New Research Opens The Door To 'functional Cure' For HIV by modelmike7(m): 9:59am On Oct 18
Good development
Re: New Research Opens The Door To 'functional Cure' For HIV by kagari: 9:59am On Oct 18
mccoy47:
Team Raw!
Time to go powered! grin grin cheesy

Saw what you did there lipsrsealed lipsrsealed undecided
Re: New Research Opens The Door To 'functional Cure' For HIV by courna(m): 10:00am On Oct 18
OK..we don hear
Re: New Research Opens The Door To 'functional Cure' For HIV by Emeka71(m): 10:00am On Oct 18
Hawlahscho:
For sale?
Re: New Research Opens The Door To 'functional Cure' For HIV by samskin(m): 10:01am On Oct 18
if they happen to find the cure for HIV and cancer God the earth will be worst than hell. it will fast forward the coming of our creator.. ashawo go they bleep nonsense comut from man dvck.
Re: New Research Opens The Door To 'functional Cure' For HIV by iamchybs(m): 10:01am On Oct 18
mccoy47:
Team Raw!
Time to go powered! grin grin cheesy


Lmao.., guy ur crase no get cure
Re: New Research Opens The Door To 'functional Cure' For HIV by gebest: 10:02am On Oct 18
all those na stories, what everybody want to hear is "we don see the cure period"
Re: New Research Opens The Door To 'functional Cure' For HIV by DirtyGold: 10:02am On Oct 18
Another improvement. Good but HIV still remains the disease to avoid.
The Pharm industry has not made enough money from HIV yet and there's no sustainable product replacement for the money-spinner ARVs
Be wise, play safe.

What's tha business?
Re: New Research Opens The Door To 'functional Cure' For HIV by musicwriter(m): 10:02am On Oct 18
The body's immune system has already defeated the HIV/AIDS virus, making it powerless even if you have it. The body was designed to work that way from creation. The body always adapt and eventually find a way to get around such situation and has been doing so for millions of years. That's why the human race has been able to survive for millions of years when there were no drugs at all. If such healing power didn't naturally exist, the human race would have gone extinct many years ago.

Western pharmaceutical companies are about to pull something big. Just watch out.

1 Like

Re: New Research Opens The Door To 'functional Cure' For HIV by Slayer2: 10:04am On Oct 18
mccoy47:
Team Raw!
Time to go powered! grin grin cheesy

God oooooo Lwkmd o, nairalanders are mad o! Mad! Mad! grin grin

Re: New Research Opens The Door To 'functional Cure' For HIV by maxiuc(m): 10:09am On Oct 18
Nigga raw and Mr Rawbison

Good news

but that shouldn't make me to jump into any well or carnal because I want pleasure
Re: New Research Opens The Door To 'functional Cure' For HIV by oshe11(m): 10:10am On Oct 18
Them never hide the cure reach




HIV WHEN PEOPLE DON EVEN FORGET.....



THEY JUST WANNA MAKE IT RELEVANT AGAINgrin
Re: New Research Opens The Door To 'functional Cure' For HIV by Soulsymbol99: 10:12am On Oct 18
There can never be a cure, u know why? Cause the moment they release the cure and you can jst walk into a pharmacy n buy d drug watch how the population of the world is goin to sky rocket cool and oyibo no go allow that. Not when they are talk climate change and how the earth is dieing. Itz a control mechanism n itz working grin

3 Likes

Re: New Research Opens The Door To 'functional Cure' For HIV by okerekeikpo: 10:13am On Oct 18
How many times una go bring out the medicine sef? Everytime u guys keep talking trash
Re: New Research Opens The Door To 'functional Cure' For HIV by omojeesu(m): 10:13am On Oct 18
Good.
Re: New Research Opens The Door To 'functional Cure' For HIV by ChangetheChange: 10:13am On Oct 18
grin
Re: New Research Opens The Door To 'functional Cure' For HIV by johncreek: 10:13am On Oct 18
mccoy47:
Team Raw!
Time to go powered! grin grin cheesy
grin grin
Re: New Research Opens The Door To 'functional Cure' For HIV by Alexbond(m): 10:17am On Oct 18
hmmmm....I thought, there was a news on nairaland months back, claiming a Nigerian has found the remedy to HIVS?
Anyways, It seems no medical discovery can be acknowledged in curing of HIVS if it's not coming from the States...It's good they have finally found one.
I hope UN/WHO would help to subsidise the drug when it is finally produced for the poor HIV syndrome carriers.

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