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Nairaland Forum / Nairaland / General / Health / "Yoruba Are Genetically Immune To Lassa Fever Virus" - Prof. Christian (28862 Views)
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Re: "Yoruba Are Genetically Immune To Lassa Fever Virus" - Prof. Christian by Shymm3x: 12:50pm On Feb 08, 2016 |
scholes0: Interesting. I'll check it out. If I can find any academic scholarship from internationally recognised bodies to corroborate the hypothesis, I'll post it on the other side. |
Re: "Yoruba Are Genetically Immune To Lassa Fever Virus" - Prof. Christian by frisky2good(m): 12:59pm On Feb 08, 2016 |
We have "eku eda'' (multimamate rats) in abundance in the south west. In fact I am still surprised it spreads lassa fever cos when I was very young we used to set traps to catch them and we handled them without caution. looseweight: |
Re: "Yoruba Are Genetically Immune To Lassa Fever Virus" - Prof. Christian by Shymm3x: 1:23pm On Feb 08, 2016 |
scholes0: Err, the hypothesis looks more plausible to me now. I just found an academic scholarship by Harvard University and it did corroborate the argument by this hypothesis about LARGE and IL21 genes being resistant to the Lassa Virus. However, it never mentioned Yorubas or any other group. This is the scholarship: https://dash.harvard.edu/bitstream/handle/1/11248782/3267117.pdf?sequence=1 |
Re: "Yoruba Are Genetically Immune To Lassa Fever Virus" - Prof. Christian by Shymm3x: 1:28pm On Feb 08, 2016 |
@scholes0 I just found another scholarship from Harvard that'd cite Yoruba, Esan, and Mende. I'll post it now - I hope the spambot doesn't ban me. cc: lalasticlala ...unban me if the spambot bans my next post. 5 Likes 2 Shares |
Re: "Yoruba Are Genetically Immune To Lassa Fever Virus" - Prof. Christian by Shymm3x: 1:29pm On Feb 08, 2016 |
Host Genetics and Human Adaptation to Lassa Hemorrhagic Fever in West Africa. S. Tabrizi1,2,3,10, R. Tariyal1,2,10, I. Shlyakhter1,2, S. F. Schaffner2, S. K. Gire1,2, M. S. Stremlau1,2, E. K. Karlsson1,2, K. G. Andersen1,2, E. Phelan2, L. M. Moses4, W. Omoniwa5, I. Odia5, P. E. Ehiane5, O. Folarin5,6, A. Tareila1,2, L. M. Branco4, J. S. Schieffelin4, D. Levy4,7, S. Gunther8, D. S. Grant7, G. O. Akpede5, D. A. Asogun5, P. O. Okokhere5, R. F. Garry4,11, C. T. Happi5,6,11, P. C. Sabeti1,2,9,11, Viral Hemorrhagic Fever Consortium 1) FAS Center for Systems Biology, Department of OEB, Harvard University, Cambridge, MA; 2) Broad Institute, Cambridge, MA; 3) Harvard Medical School, Boston, MA; 4) Department of Microbiology and Immunology, Tulane University, New Orleans, LA; 5) Institute of Lassa Fever Research and Control, Irrua Specialist Teaching Hospital, Edo State, Nigeria; 6) Department of Biological Sciences, College of Natural Sciences, Redeemer's University, Redemption City, Ogun State, Nigeria; 7) Lassa Fever Laboratory, Kenema Government Hospital, Kenema, Sierra Leone; Lassa Fever Laboratory, Kenema Government Hospital, Kenema, Sierra Leone Department of Virology, Bernhard-Nocht-Institute for Tropical Medicine, Hamburg, Germany; 9) Department of Immunology and Infectious Disease, Harvard School of Public Health, Boston, MA; 10) These authors contributed equally to this work; 11) These authors jointly supervised this work. Lassa virus has the unique status of being both one of the world’s deadliest pathogens, designated bio-safety level 4 (BL-4), and a public health crisis, endemic in large parts of West Africa. It is estimated to have originated over 1000 years ago in Nigeria, and a genome-wide survey of human variation identified the gene LARGE, biologically linked to Lassa virus infection, as among the strongest signals of natural selection in the Yoruba population of Nigeria. We pursued the hypothesis that Lassa virus is an ancient selective force, driving the rise of genetic resistance, by conducting a genome-wide association study (GWAS) of Lassa fever cases and controls in Nigeria and Sierra Leone. We report a signal of association at LARGE, and show that it overlaps with the previously reported signal of selection. This suggests recent evolution of resistance to Lassa fever in West Africa, making it one of only a handful of known loci under positive selection elucidated to be involved in resistance to infectious disease. Population genetics analysis provides further insights into the origins and spread of the resistance variant in LARGE. We show that the same putatively protective haplotype under selection in the Yoruba is also present in the Esan population of Nigeria and the Mende population of Sierra Leone. We find that the frequency is highest in the Yoruba (30%), lower in the Esan (21%) and the Mende (10%), and absent in East African and non-African populations (where Lassa fever is also absent). This is consistent with results from our sequencing of the Lassa genome showing that the virus is oldest in Nigeria and appeared only recently in Sierra Leone, and helps to explain higher fatality rates and greater disease severity in Sierra Leone. Beyond LARGE, our other top GWAS signals fall at genes involved in the immune system, including PTPRE, which modulates expression of cytokines involved in host response to viral infection, and IFRD1, involved in the activation of neutrophils in innate immune response. We also examine signals of adaptation in the Esan and Mende populations and discover numerous novel candidate loci under positive selection, providing new insights into human diversity in West Africa. This work is one of only a few surveys of genetic diversity in West Africa, a region underrepresented in GWA studies. It is also the first ever GWAS on a BL-4 agent, and demonstrates a novel genomics approach to understanding the world’s deadliest pathogens. You may contact the first author (during and after the meeting) at tabrizi@post.harvard.edu http://www.ashg.org/2013meeting/abstracts/fulltext/f130122559.htm 4 Likes 1 Share |
Re: "Yoruba Are Genetically Immune To Lassa Fever Virus" - Prof. Christian by imsuboi(m): 1:38pm On Feb 08, 2016 |
sauceny: Very clean |
Re: "Yoruba Are Genetically Immune To Lassa Fever Virus" - Prof. Christian by Wolfbrother(m): 1:56pm On Feb 08, 2016 |
Lemon12: Guy this gist touched you in unreachable places , this thing dey pain you die 2 Likes |
Re: "Yoruba Are Genetically Immune To Lassa Fever Virus" - Prof. Christian by tj78: 2:01pm On Feb 08, 2016 |
Some pple are so daft! We don't cherish our researchers nor do we value our stuffs. The most annoying thing is that some pple knw nothing abt science yet they comment foolishly! As deadly as ebola was, some pple survived. There's no disease known to man that some few pple aren't resistant to. Its very possible for yoruba pple to have resistance to lassa fever, and other tribe could be resistant to other diseases. This resistance could be due to their ancestral history, their type of food or even location. Pls don't turn nairaland to a dumb place, the whole world is reading it. And if u are foolish, isn't it wise to hide ur foolishness? 5 Likes 1 Share |
Re: "Yoruba Are Genetically Immune To Lassa Fever Virus" - Prof. Christian by pastormellanby: 2:57pm On Feb 08, 2016 |
The wailers are prone to 419, ritual killing, pipeline vandalization, examination malpractices, theft and evil thinking. |
Re: "Yoruba Are Genetically Immune To Lassa Fever Virus" - Prof. Christian by emiye(m): 2:59pm On Feb 08, 2016 |
Decryptor:Yorubas has the highest twin conception rate in the world. |
Re: "Yoruba Are Genetically Immune To Lassa Fever Virus" - Prof. Christian by Smooyis(m): 4:27pm On Feb 08, 2016 |
Yorubas should not be deceived by this finding and now ignore basic hygiene standards. This may be tragic at the end. |
Re: "Yoruba Are Genetically Immune To Lassa Fever Virus" - Prof. Christian by totit: 4:41pm On Feb 08, 2016 |
Smooyis: Is this suppose to be funny |
Re: "Yoruba Are Genetically Immune To Lassa Fever Virus" - Prof. Christian by Ubenedictus(m): 4:54pm On Feb 08, 2016 |
oodua1stson:I understand, just dont go down to their level. |
Re: "Yoruba Are Genetically Immune To Lassa Fever Virus" - Prof. Christian by churchboy608(m): 4:56pm On Feb 08, 2016 |
lol.... I laff in spanish :Dlol.... dat kind immune.. Rat no sabi tribe ooo. Hmmmm dem neva Chichuntin. |
Re: "Yoruba Are Genetically Immune To Lassa Fever Virus" - Prof. Christian by Decryptor(m): 5:12pm On Feb 08, 2016 |
emiye: Who highest twin conception rate help? |
Re: "Yoruba Are Genetically Immune To Lassa Fever Virus" - Prof. Christian by Babalegba(m): 5:18pm On Feb 08, 2016 |
emiye:That's a fact. |
Re: "Yoruba Are Genetically Immune To Lassa Fever Virus" - Prof. Christian by oodua1stson: 5:24pm On Feb 08, 2016 |
Ubenedictus:thanks bro |
Re: "Yoruba Are Genetically Immune To Lassa Fever Virus" - Prof. Christian by Smooyis(m): 6:04pm On Feb 08, 2016 |
totit: Not at all. Just stating the obvious. |
Re: "Yoruba Are Genetically Immune To Lassa Fever Virus" - Prof. Christian by Nobody: 8:24pm On Feb 08, 2016 |
Lemon12: |
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