dreshemokha:
Op. Genetics and health is not mathematics as you just calculated.
And yes it is totally IMPOSSIBLE, a marriage between AA and AS can NEVER produce SS.
Moreover, there is no relationship in inheritance between sickle cell diseases and thalassemias.


Am a doctor with a health blog. Check my signature and visit my blog for robust health info and publications.

Piiko:
I am AS and I hope the love of my life is AA I only want 1 kid, I don't want a Sickler God abeg give me AA wife

Crixina:
Dear Op, as much as you are trying to be educative...you lost most of us...A post like this should be brought to a layman's understand, the use of some terms there are rather too vague most people's comprehension.

dreshemokha:
Op. Genetics and health is not mathematics as you just calculated.
And yes it is totally IMPOSSIBLE, a marriage between AA and AS can NEVER produce SS.
Moreover, there is no relationship in inheritance between sickle cell diseases and thalassemias.


Am a doctor with a health blog. Check my signature and visit my blog for robust health info and publications.

sainty2k3:

Please verify and update ur stuffs , the informations provided and also buttressed by the first comment explains it all. Bothe the qualitative genetic abnormalities that leads to Hb S and the quantitative abnormalities in thalassemia can be co inherited otherwise known as S beta thallasemia . I have seen some cases like this , I'm very sure of this fact and for your information I'm not a mathematician, I simply stated a medical fact

darlenese:
nonsense and ingredient.


no AS and AA has ever given birth to an SS. carry your rubbish theory and gerrahere.



mshweeeeeeew.

sainty2k3:
YES it is not impossible, couples that are AA/AS can give birth to SS , this is how
1. let me differentiate between haemoglobin genotype and haemoglobin phenotype
To get a particular GENOTYPE you have to do a genetic testing or use two or more of the screening test (the conventional electrophoresis that we do + HPLC or other similar test) to confirm the true genotype while hb PHENOTYPE is the appearance /characteristics of an individual haemoglobin on conventional electrophoresis which we loosely refer to as GENOTYPE
Most times when we call ourselves AA,SS,AS we are actually referring to our Haemoglogin PHENOTYPE and NOT GENOTYPE, as most of us don’t do genetic tests, all we do is haemoglobin electrophoresis
2. lets explain the concept of thalasemic trait. Thalassemias are quantitative defect of haemoglobin which means some one can be AA but the one or both A in this person is is absent otherwise known as thalassemia minor and major respectively. If such person run haemoglobin Electrophoresis( the test that we always loosely regard to as genotype) only A band will be seen and such a person will be regarded as AA. But they are also prone to anaemias and some certain abnormal features in the blood depending on the degree in the reduction in the defective A . such individuals can be Aβ-Thalassaemia(otherwise known as thalassaemic trait) if one of the’ A gene’ is normal, or β-Thalassaemia major if both are affected
3. lets merge the two concepts above and form AND SEE THE DIFFERENT PHENOTYPE THAT EXIST AND THE POSSIBLE CORRESPONDING GENOTYPE
If PHENOTYPE is AA the likely GENOTYPES will be AA , Aβ-Thalassaemia
If PHENOTYPE is SS the likely GENOTYPES will be SS, Sβ-Thalassaemia (MEANING THE OTHER ‘A’ THAT WOULD HAVE MADE THIS AN ‘AS’ IS TOTALLY ABSENT) Others might include SD,SG etc though these are very rare
If PHENOTYPE is AS the likely GENOTYPES will be SA (NOTE – ‘S’ COMES BEFORE ‘A’ BECAUSE THE A IS THALASSAEMIC, THOUGH NOT TOTALLY ABSENT AS THE ONE ABOVE ,IT IS SUSBSTANTIALLY REDUCE), or truely AS
4. Lets assume this our hypothetical couple have Hb eleterophoresis done and was told that the genotype of partner 1 is AA, and that of partner 2 is AS ,but the one that is called AA is actually Aβ-Thalassaemia as ealier mentioned. There possible offspring include
I. AA, If the child inherit the normal A from partner 1 and another normal A from partner 2
II. Aβ-Thalassaemia ,If the child inherit β-Thalassaemic A from the partner 1 and normal A from partner 2
III. AS,If the child inherit normal A from partner 1 and S from patner 2
IV. Sβ-Thalassaemia If the child inherit β-Thalassaemic A from partner 1 and S from partner 2
Note that scenario I above will show AA on Hb electrophoresis, scenario ii will show AA on electrophoresis, scenario iii will show AS on electrophoresis and scenario iv will show SS on electrophoresis
I have tried to simplify the medical terms but if you still have a doubt or clarification ask and I will try to shed more light, as much as I can.

sainty2k3:

That is if the AA is actually AA genotype and not A beta thalassemia , note that from the explanation above On HB electrophoresis, whicjbwe all loosely refer tonas genotype all of them will appear as AA

funmisticqueen:
Please quote your refrences for all this information.

sainty2k3:

Calm down, these ain't theory , its what we have seen ,life and direct

sainty2k3:
YES it is not impossible, couples that are AA/AS can give birth to SS , this is how
1. let me differentiate between haemoglobin genotype and haemoglobin phenotype
To get a particular GENOTYPE you have to do a genetic testing or use two or more of the screening test (the conventional electrophoresis that we do + HPLC or other similar test) to confirm the true genotype while hb PHENOTYPE is the appearance /characteristics of an individual haemoglobin on conventional electrophoresis which we loosely refer to as GENOTYPE
Most times when we call ourselves AA,SS,AS we are actually referring to our Haemoglogin PHENOTYPE and NOT GENOTYPE, as most of us don’t do genetic tests, all we do is haemoglobin electrophoresis
2. lets explain the concept of thalasemic trait. Thalassemias are quantitative defect of haemoglobin which means some one can be AA but the one or both A in this person is is absent otherwise known as thalassemia minor and major respectively. If such person run haemoglobin Electrophoresis( the test that we always loosely regard to as genotype) only A band will be seen and such a person will be regarded as AA. But they are also prone to anaemias and some certain abnormal features in the blood depending on the degree in the reduction in the defective A . such individuals can be Aβ-Thalassaemia(otherwise known as thalassaemic trait) if one of the’ A gene’ is normal, or β-Thalassaemia major if both are affected
3. lets merge the two concepts above and form AND SEE THE DIFFERENT PHENOTYPE THAT EXIST AND THE POSSIBLE CORRESPONDING GENOTYPE
If PHENOTYPE is AA the likely GENOTYPES will be AA , Aβ-Thalassaemia
If PHENOTYPE is SS the likely GENOTYPES will be SS, Sβ-Thalassaemia (MEANING THE OTHER ‘A’ THAT WOULD HAVE MADE THIS AN ‘AS’ IS TOTALLY ABSENT) Others might include SD,SG etc though these are very rare
If PHENOTYPE is AS the likely GENOTYPES will be SA (NOTE – ‘S’ COMES BEFORE ‘A’ BECAUSE THE A IS THALASSAEMIC, THOUGH NOT TOTALLY ABSENT AS THE ONE ABOVE ,IT IS SUSBSTANTIALLY REDUCE), or truely AS
4. Lets assume this our hypothetical couple have Hb eleterophoresis done and was told that the genotype of partner 1 is AA, and that of partner 2 is AS ,but the one that is called AA is actually Aβ-Thalassaemia as ealier mentioned. There possible offspring include
I. AA, If the child inherit the normal A from partner 1 and another normal A from partner 2
II. Aβ-Thalassaemia ,If the child inherit β-Thalassaemic A from the partner 1 and normal A from partner 2
III. AS,If the child inherit normal A from partner 1 and S from patner 2
IV. Sβ-Thalassaemia If the child inherit β-Thalassaemic A from partner 1 and S from partner 2
Note that scenario I above will show AA on Hb electrophoresis, scenario ii will show AA on electrophoresis, scenario iii will show AS on electrophoresis and scenario iv will show SS on electrophoresis
I have tried to simplify the medical terms but if you still have a doubt or clarification ask and I will try to shed more light, as much as I can.

tiwasiaife:
Its possible
How?
1 if the husband has slept with a woman who has just finished sex within seconds and the man happens to be AS and deposited sperm inside the woman's vagina and the man comes and sleep with her and uses his penis tips to collect some spermatozoa deposits inside the woman's vagina and going back to her wife immediately to have sex there is tendency that the sperm collected from the other woman can first move after ejaculation and fertilizes her wife's ovary thereby giving the child an SS carrier

sgtponzihater1:


While I know where u are driving at. The above explanation will give HBSthal, which is different from HBSS. The former have less sickling events and can lead nearly normal lives with very few crises. But Only mutation would cause AA that married AS to give birth to SS, such phenomenon, while feasible theoretically have never been documented. Weldone anyways.

LionDeLeo:
OP, I did not bother to read your analysis because I know you just want to make noise.

What you are saying is the most impossible thing on Earth.

Even AA & SS cannot produce SS, not to talk of AA & AS.

sainty2k3:
YES it is not impossible, couples that are AA/AS can give birth to SS , this is how

I have tried to simplify the medical terms but if you still have a doubt or clarification ask and I will try to shed more light, as much as I can.

Jointhemiltons2:

Am not even sure dah OP go school sef or even study Biology cos it's never possible

darlenese:




I think those people who have experienced this should go for a DNA test, instead of assuming the possibility a theory that has not be propounded by anybody. this assumption isn't correct if it has not be proven, and it shouldn't even be brought to front page in the first place.

beamtopola:

Pls stop misleading Nigeria, there is no research done on this by usa : a black man can't get it right. It is never possible and its impossible for AA and AS to give birth to SS, nairaland shold stop promoting nonsence. The only phenotype we carry out its ABO where by their is dorminant and hiding gene. Here A+ and B+ can give birth to O. Pls genotype is genotype, and stop misleading Nigeria.