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How do you expect answer here even professional doctors are confused and you want answers from Nairalanders? How

funshiba:


lie

I will ignore you cos ignorance is a major problem i see. No comment further on this

Go and read your old post or i should help you to post it here

kay9:


I agree. Both himself and the wife, in fact.

But mehn, he needs to be careful and really wise here - what if the wife is telling the truth? I must be honest here though, from my limited knowledge of these things it is IMPOSSIBLE for a carrier and a non-carrier to produce a sickler - Mendel's laws of genetics would have to be rewritten. But you know what they say, never say never.

Now that I think of it, the gender of a foetus is dependent on similar genetic laws: the man gives one from his (xy) and the woman gives one from her (xx), so the offspring is either (xx) x-from dad and x-from mum, or (xy) y-from dad and x-from mum. But every once in a crazy while, an (xxy) or something weird like that is produced, and that's how you get hermaphrodites. So... oga needs to be careful with his decision. By the way, has the woman ever given him cause to doubt her fidelity? One doesnt just throw away a 10-yr-old marriage like that.

This is very strange, near impossible, thgh i agree, NEVER SAY NEVER IN MEDICINE.

People may lie, forge, cut corners, science does not.One of d couples knw d truth.

Been a lot of similar clinical cases, but d truth always come out.science was always correct.


Again i dont knw what paternity test was done, but a DNA testing is what is needed. This would unravel d mystery.

The labs whr these are done is anoda thing, depending on wat d couple may stnd to gain or lose if d truth is established. If they are serious, i wld recommend Pathcare.

The truth may not be enough to break d marriage in my opinion.It largely depends on d couples..Perhaps this attitude would hlp d truth to come out.

ONE OF THE COUPLES IS NOT TELLING THE TRUTH!!

[quote author=IdiAmin1 post=33648442]The kid probably has two fathers then. The wife should open up on what transpired immediately before or immediately after meeting her husband as at the time she conceived.
no doubt about that, there is mix up somewhere

If this story is true, then they should go and look for their real child because their baby was intentionally or mistakenly switched immidiately after birth.

Demichaels:
My friend's 10 year Marriage is about to collapse.

His, my friend's genotype is AA and his wife's genotype is AS but their 4 year old daughter has been confirmed to have SS genotype by not less than 4 different medical experts. He confronted the wife and accused her of infidelity but she vehemently denied having any affair with another man. In other to prove her wrong, my friend subjected the little girl to a paternity test and there he got the shock of his life - the result showed he actually is the father of the girl. At first he accused the doctor of compromise because he is their family doctor and somehow relates to the wife. He then decided to go to another hospital to prove the paternity of the girl child there and then he got another shocker - the first result was actually correct. As It stands, my friend has consulted more than five other doctors outside the state of his residence and all Confirmed that the girl's genotype is SS and he actually is the father of the child despite his and the wife's genotype being as stated above. Even the doctor's are confused by the results as it negate conventional medical norm.

My question now is, experts in the house, is there anything that can lead to such unconventional biological flaw? Under what condition can AS and AA couple have an SS child? Can mutation lead to such condition? My friend insists on divorce because he doesn't believe the wife. Should he go ahead based on what we all know about genotype?


Please I need matured advice on this. This is a REAL LIFE SITUATION AND NO FICTION. I WOULD HAVE MENTIONED NAMES AND ADDRESS OF THE COUPLE BUT I DON'T HAVE THEIR PERMISSION YET. THIS IS HAPPENING RIGHT HERE IN PORT HARCOURT OLD GRA WE'RE LIVING

The husband needs to be re-educated. Spontaneous mutation was how we got the very first sickle gene "S", humans were not created with it. same applies for many other mutations that cause many defects and cancer. Perhaps he should take the test with a Lab technician only he knows if not he'd just be destroying his marriage out of ignorance and half-knowledge. Better to not know at all, than to be half-knowledgeable.

am also on d same situation, but it is only DAT my parents are not taking it serious dad ac mum as and am sc. check out did thread.
www.nairaland.com/2053511/it-possible-aa-genotype-give

oluwalfa:
Does the husband have a brother that is AS or SS? Sometimes women having difficulty conceiving mate with their husband's family so the DNA stays the same as the husband's.

I second this motion.

people are too stupid especially on nairaland.

It's very very possible especially in Nigeria where we do hemoglobin electrophoresis for determining genotype.
in this case a thalassemia AA gene from the male may present as AS this making the born child SS.
only molecular genetic testing rarely done in Nigeria and which is expensive can give you true values..

I pity those who think it's all about aa+AS= aa+as+aa+as.. secondary school biology isn't really 100% true..

btw,all doctors know this..only people are too impatient to hear them or they prefer to stick to the secondary school genetics teaching

nervorum:


This is very strange, near impossible, thgh i agree, NEVER SAY NEVER IN MEDICINE.

People may lie, forge, cut corners, science does not.One of d couples knw d truth.

Been a lot of similar clinical cases, but d truth always come out.science was always correct.


Again i dont knw what paternity test was done, but a DNA testing is what is needed. This would unravel d mystery.

The labs whr these are done is anoda thing, depending on wat d couple may stnd to gain or lose if d truth is established. If they are serious, i wld recommend Pathcare.

The truth may not be enough to break d marriage in my opinion.It largely depends on d couples..Perhaps this attitude would hlp d truth to come out.

ONE OF THE COUPLES IS NOT TELLING THE TRUTH!!

bro don't just say it is impossible, cos it is happening to me also. www.nairaland.com/2053511/it-possible-aa-genotype-give

.

milychocs:



Exactly
A sickling gene is a sickling gene...so people stop with the AC and Thalassaemia knowledge, we know you you know it
Lawd

And we know you dont know it.
Stop displaying your ignorance.

Culd b that d SS is a recessive in both him and d wife's family, let him go and investigate both family trees.

Demichaels:
My friend's 10 year Marriage is about to collapse.

His, my friend's genotype is AA and his wife's genotype is AS but their 4 year old daughter has been confirmed to have SS genotype by not less than 4 different medical experts. He confronted the wife and accused her of infidelity but she vehemently denied having any affair with another man. In other to prove her wrong, my friend subjected the little girl to a paternity test and there he got the shock of his life - the result showed he actually is the father of the girl. At first he accused the doctor of compromise because he is their family doctor and somehow relates to the wife. He then decided to go to another hospital to prove the paternity of the girl child there and then he got another shocker - the first result was actually correct. As It stands, my friend has consulted more than five other doctors outside the state of his residence and all Confirmed that the girl's genotype is SS and he actually is the father of the child despite his and the wife's genotype being as stated above. Even the doctor's are confused by the results as it negate conventional medical norm.

My question now is, experts in the house, is there anything that can lead to such unconventional biological flaw? Under what condition can AS and AA couple have an SS child? Can mutation lead to such condition? My friend insists on divorce because he doesn't believe the wife. Should he go ahead based on what we all know about genotype?


Please I need matured advice on this. This is a REAL LIFE SITUATION AND NO FICTION. I WOULD HAVE MENTIONED NAMES AND ADDRESS OF THE COUPLE BUT I DON'T HAVE THEIR PERMISSION YET. THIS IS HAPPENING RIGHT HERE IN PORT HARCOURT OLD GRA WE'RE LIVING

Let the both of them go for a repeat genotype test please

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MistadeRegal:
Pay attention to my story.
I am the third child but the first son. My sisters look exactly like my mum and dad respectively. My younger brothers look like my parents also respectively while I am different. My dad never treat me different from others and whenever he's scolding me, he always say, "I am your father and I won't watch you ruin!" Years later, I recalled as I grow taller, my grandmother(dad's mum) came visiting. And when it's morning, I went to greet her our native way. She pulled me up and began our lineage pedigree, I didn't look up at her and then she raised my head up and gave me the first shock!...She called my dad sharply and said to him with her eyes wide open, "This is the exact figure of your father!"
Since then, she always call me her husband.

Now, two years ago, my uncle(dad's elder brother) died. We all went to his home town. Dad took I and my uncle's son to greet some elders. We went round and came to the chief's(Baale) house where we all were assembled and he started eulogising us for the dead. This was where I got abother shock. I have never met this old man ever before but to my surprise, as many as we are there with him, while he was still speaking, I looked up, he paused and pointed at me saying same words, "Of all those here, ONLY YOU took after the beauty of your grandfather!" Everyone turned and stared at me! Some of my cousins whispered, "A je pe grandpa fine gan niyen o!"(That means grandpa is very handsome!) Then he(Baale) continued hus words....

Now what am I trying to tell your friend, if DNA proves he is the father of that girl, she could have taken after any of his grannies. He should never doubt his innocent wife and paint her a colour she never deserves.

Can you explain what you are trying to say?

Is he sure he is trully aa? Cos I remember me own case. Going about thinking I was AA o+ only to go outside nd get tested as b+, thogh I avent done that genotype one yet, but I'm sure twill b fake as well

koyyess:
Only the test of time in marriage can expose how enlightened and mature a couple truly is. Even after he was told by more than two doctors that the child is his, he still wants to deny his responsibility and seek for divorce? Op, your friend is a bush man with the heart of a chicken.

Deluded psycho!! Do u know how it feels to be betrayed?!

Some people will kick against what I want to say now,though it won't matter anyway.

Let them take that Child to Doctor Jesus,He has the solution.

Go to any living church like "Watchman Catholic Charismatic Renewal Movement" or Deeper Life Bible Church and the likes,and meet their pastor.

After the meeting,next will be testimony.

Demichaels:
My friend's 10 year Marriage is about to collapse.

His, my friend's genotype is AA and his wife's genotype is AS but their 4 year old daughter has been confirmed to have SS genotype by not less than 4 different medical experts. He confronted the wife and accused her of infidelity but she vehemently denied having any affair with another man. In other to prove her wrong, my friend subjected the little girl to a paternity test and there he got the shock of his life - the result showed he actually is the father of the girl. At first he accused the doctor of compromise because he is their family doctor and somehow relates to the wife. He then decided to go to another hospital to prove the paternity of the girl child there and then he got another shocker - the first result was actually correct. As It stands, my friend has consulted more than five other doctors outside the state of his residence and all Confirmed that the girl's genotype is SS and he actually is the father of the child despite his and the wife's genotype being as stated above. Even the doctor's are confused by the results as it negate conventional medical norm.

My question now is, experts in the house, is there anything that can lead to such unconventional biological flaw? Under what condition can AS and AA couple have an SS child? Can mutation lead to such condition? My friend insists on divorce because he doesn't believe the wife. Should he go ahead based on what we all know about genotype?


Please I need matured advice on this. This is a REAL LIFE SITUATION AND NO FICTION. I WOULD HAVE MENTIONED NAMES AND ADDRESS OF THE COUPLE BUT I DON'T HAVE THEIR PERMISSION YET. THIS IS HAPPENING RIGHT HERE IN PORT HARCOURT OLD GRA WE'RE LIVING

yes. we have such a situation in my family. my brother has since researched and found out that such issues are as a resultof recessive SS stuff on one of the parents. he also threw in some other jargons live PCV (packed cell volume) and shait.

he is a pharmacist and i am a civil engineer.
dont ask me for any more explanation please.

To clear all doubt, they should all go a step ahead and have a real DNA test..

laplace12:

The only thing possible here is that the story is fake

True.

Too much detail, plus all the myriads of labs etc.

Focus should be on managing the child's crises, not endless lab testing for genotype.

Riddle is solved., so no alarm for cause !!

The child is "Sc" and not "Ss" as reported by labs scientists.

d33types:
people are too stupid especially on nairaland.

It's very very possible especially in Nigeria where we do hemoglobin electrophoresis for determining genotype.
in this case a thalassemia AA gene from the male may present as AS this making the born child SS.

I pity those who think it's all about aa+AS= aa+as+aa+as.. secondary school biology isn't really 100% true..

even DNA paternity test is not 100% accurate.. Efficiency of a machine is not 100% because "work"is done to overcome frictional force..

tpiadotcom:


True.

Too much detail, plus all the myriads of labs etc.

Focus should be on managing the child's crises, not endless lab testing for genotype.

both my parents are/were AA, one of my sisters is AS, one of my brother is SS, his twin is AA.
dont come and start talking about what you dont really know about.

The couple can report their issue directly to WHO & when they're contacted, the whole family will be taken as lab rat for experiments. If both husband and wife are saying the truth, medical professionals can learn new things from their family

adconline:

Deluded psycho!! Do u know how it feels to be betrayed?!

Betrayed? Are you the one who slept with his wife? Did you read any part in the op's post that said the child was not his? You must be an infested rabies patient to bark at me. Empty headed Dog lover.

ralph28:
Some people will kick against what I want to say now,though it won't matter anyway.

Let them take that Child to Doctor Jesus,He has the solution.

Go to any living church like "Watchman Catholic Charismatic Renewal Movement" or Deeper Life Bible Church and the likes,and meet their pastor.

After the meeting,next will be testimony.

Living in Utopian Island! How many Ebola victims were cured by these ur so-called men of God??

Go for DNA ooo, that kid does not belong to d man

Away match by d wife is karid! DNA 1time!