patrick2:

Abali.. Pls I need the following information from you. (1) Are you male or female and how old are you? (2)How long (Months or years) have you been using the Cellod-S? (3) Have you had any crisis since then? (4) In your opinion is the drug curative or preventive? (5) Does the drug have any side effect?. I will appreciate your feedback based on your past experience with the drugs. I am making these enquiries for my younger brother who is 37 years old. Thanks

Abali1:
Patrick, am sorry that my response is a bit late. I just got back from an official journey.
1) I am male
2) i started using cellod-s from July/August of this year. Like I said I got the info about the drug, from here NL and the website blink provided.
3) Even before I started using the drug, I rarely have crisis. I was using another herbal medicine called DIOSCOVITE. It's a clear colorless liquid like water. I do combine it with my monthly malaria preventive.
4) Since I started taking Cellod-s, I have stopped taking any other medication. But, I still do take a lot of water everyday. Apart from headache, I have not had any problem.
In my position (as a lay man, I believe cellod-s is curative. But I can't prove that ).

5) To the best of my knowledge, I have not noticed any side effect. And like I said earlier, the EFFECT OF WATER CANNOT BE OVEREMPHASISED. A lot of water can do wonders, believe me.

Your brother is just a couple of years older than me. A little reading and research can do sicklers a world of good. Awareness is very important, spread it.

Abali1: When I got to the University, I was already armed with enough info and experiences regarding SCA. I have also gotten to understand my system in a very unique way. ( Parents and Loved ones of SS persons, this is very necessary)
In my case, I can sense a crisis way before it actually becomes something else.
My school was very far away from my mum this time. So, I was left to my own vices.
With that arrogant sense that comes upon CHAMPIONS every now and then, I decided to test Fate in different ways. I took to drinking alchohol with my buddies and also took up smoking (these are very deadly habit for any sickler to indulge in).
Though I didn't forget taking my medications, but it wasn't as regular as it used to be.
In my year two, I had a totally different kind of crisis. This time around the pain was on my leg, precisely the soles of my feet. I was rushed home (it was during one of those times that police killed a student and I followed others to protest the killing by marching on the road, we were heading to Alausa).
My sister took me to a hospital and the doctors said I had tumours growing there, that my leg will be amputated. I cried and begged God not to allow me go through this one. The Doctors said I was going to wear a POP for a month, that if it doesn't improve then the leg will be amputated.
After loosening the POP at the end of the month, I was asked to walk around. I felt some pain, but I decided that I will rather live with the pain than allow anybody to cut off my leg. And at the end, my Faith and Trust in God triumphed.

Techwriter: I don't know whether these are facts or myth but when I sought friends advice on whether to marry a fellow AS. One told me that the possibility of giving birth to a sickler is from my 3rd baby. That I can actually stop at two and be safe. I also heard in my teenage years that ones an SS gets to 30, the symptoms ceasing and he can't die from the condition. Is that true?

Unimke_Ak: [s][/s]A know of some facts about SCD, being a suffer my self and I have also had of some myths concerning SCD. I will like others to add the fact and myth the also know or have heared of. Thank You.
FACTS:
SCD, is a blood disease. It is inherited from from the HB s genes of both parents.(so it's both parents that should share the blame game, if any)

SCD crisis occurs when you have a mutation of the red blood cells(the doctors and lab scientists should explain better
Crisis is not always painful ,but it can also be extreemly painful (you wouldn't wish your enemies that can of pain)

In summation, this is a LOUSY WRITE UP.

debojyde:

It's a thing of probability. The simplest way to explain it to you is that if ur genotype is AS and ur wife's genotype is AS,each child u have as a 1 in 4 (25%) chance of ending up with a genotype that is SS. ...... U could have 20 children and they would all be SS or U could have 20 children and none of them will be SS. But each child u have as a 25% chane of beeping an SS and 25% chance is quite high.

I know parents who are both AS and none of their 5 kids are SS. ( They are either AA or AS). . I also know a family whose parents are both AS and all 3 kids carry the SS genotype.

debojyde:

It's a thing of probability. The simplest way to explain it to you is that if ur genotype is AS and ur wife's genotype is AS,each child u have as a 1 in 4 (25%) chance of ending up with a genotype that is SS. ...... U could have 20 children and they would all be SS or U could have 20 children and none of them will be SS. But each child u have as a 25% chane of beeping an SS and 25% chance is quite high.

I know parents who are both AS and none of their 5 kids are SS. ( They are either AA or AS). . I also know a family whose parents are both AS and all 3 kids carry the SS genotype.

nysot:

In Genetics, during crossing, the possibility of you giving birth to a sickler is from the fourth child, the first child would be AA, the second and third children would be AS while the fourth would be SS.

In reality, this might not happen. I have a friend who is SS and he is the first child. Both parents are AS, they planned to have 3 children with the mindset that 1 would be AA and the other 2 would be AS. But that did not work for them, they had the first and he is SS.

So, you can never tell.

patrick2:


How do you explain the case of a woman with 3 kids from the first husband and another 3 kids from a second husband (the brother of the dead husband as permitted by tradition) making a total of 6 kids. 1 kid from each of the husband (2 kids)are SS??. The other 4 kids are not...

amarush: Me and my husband are both AS. We found out i was AS after i got preganant as part of my antenatel care in hospital. Hubby had been tested in naija and was told he was AA, but the hospital wanted to test him also, apparently if you are from asia or africa they will retest you as they have come across people who have been misdiagnosed. Anyway, hubby was tested and he was also AS, he was sooooooo shocked as tested as a teen and always belived he was AA. We have two kids, the first is AA (3 years old) and the second is AS (7 months old).

btw his older sister was tested in naija and told she was AA, she was retested over here (UK) and is infact AS, luckily her husband is AA. They were both tested a number of years ago and i hope that the procedures have tightned up. Misdiagnosis is no joke.

debojyde:

It's a thing of probability. The simplest way to explain it to you is that if ur genotype is AS and ur wife's genotype is AS,each child u have as a 1 in 4 (25%) chance of ending up with a genotype that is SS. ...... U could have 20 children and they would all be SS or U could have 20 children and none of them will be SS. But each child u have as a 25% chane of beeping an SS and 25% chance is quite high.

I know parents who are both AS and none of their 5 kids are SS. ( They are either AA or AS). . I also know a family whose parents are both AS and all 3 kids carry the SS genotype.

Abali1:

SCD persons don't have malaria ( please no allow mosquitoes near anybody whey get SCD)

apocalypse:

Your analysis is wrong , the thing is an AS/AS couple can have four of any kind of combination : one AA and three SS , one AA and three AS , one AS and three AA , one AS and three SS , one SS and three AA , one SS and three AS , two AA and two AS , two AA and two SS ... Infact they can have all round AA , AS or SS . The thing is every birth is independent of the other , so for every birth the probability of having an AA is 25% , AS 50% and SS 25%.
More so the gene pool remains the same if there is no manipulation.
I wouldn't want to have SS children but I know science has gone a long way to address issues that might arise from genotype incompatibility.

I still give my vote to love on this one

apocalypse:

Your analysis is wrong , the thing is an AS/AS couple can have four of any kind of combination : one AA and three SS , one AA and three AS , one AS and three AA , one AS and three SS , one SS and three AA , one SS and three AS , two AA and two AS , two AA and two SS ... Infact they can have all round AA , AS or SS . The thing is every birth is independent of the other , so for every birth the probability of having an AA is 25% , AS 50% and SS 25%.
More so the gene pool remains the same if there is no manipulation.
I wouldn't want to have SS children but I know science has gone a long way to address issues that might arise from genotype incompatibility.

I still give my vote to love on this one

kpozite:
SCD persons have higher resistance to malaria than AS and AA. i.e. theirs is mild

richie-x:
Hi Alabi1, was just reading through your post and i believe there are now advanced ways for couples who are both AS/AS to have healthy children.
I did my genotype test and was told i was AS and was refered to Manchester genetics for help and they actually had some advice for me.
They recommended IVF, called (gene selection) for the unborn and also bone marrow transplant for the child already born as well.

Also, my friend whose baby is just three took his daughter to India for a bone marrow transplant and as we speak, her bone marrows now produce normal blood cells rather than the deficient sickle shaped one, she plays and runs like a normal child.

And oh!, i'm still single.

Abali1:

Please, I have had this arguement with someone else on another thread. You can read my story in this thread, and I beg you do not mis-inform the public. Malaria attack if not handled well, will result to the death of a SCD person.

Gracious10:

I concur!