₦airaland Forum

dangoteinlaw:
The citizens suffering are only doing themselves. What does it cost to open a palmpay account, even some have accounts but adamantly refuse to accept transfers because a fool will buy money to in turn buy goods from them. There’s absolutely nothing wrong with this policy except the illiterates suffering from it implementation.

Are you ignorant or something? There are a lot of illiterates in the country that can’t operate a smartphone. Also, moving short distance of 50-100naira, do you expect people to be transferring that amount?

Hahaha. Same way you guys were not involved in the protection of civilians during the election.

Adakintroy:
Women rejecting you as a man is functional. Its part of our drive to strive hard. If women accept you the way you are you wil be average. We need women to reject us so we can strive hard to be accept.

And when you strive harder and become better, make sure you don’t settle for less, or the same kind of lady that rejected you.

Draslo:
Comments like this on posts like this is why I will continue to call Yorubas who voted PO bastards and saboteurs. This particular crime is everywhere in Nigeria. I remember one particular Okija shrine but somehow, it is a Yoruba thing because Nairaland Igbos will do anything to taint Yorubas. The era of being liberal is gone. I have become a tribalist as well. I will give you all a taste of your own medicine.

Like Lesotho like Biafra

Putting politics aside, they have not faced the one in their backyard. With the killings gistlover exposed in anambra.

Anyone can vote who they like, but shouting skill mining when they also do it and cover it up is pitiable

If you know you are still hurt and you can’t give your love to him yet. Let him know and let him be.

Don’t use your issues to damage a good guy. Let him be!!!

Jokers

Supersymetry:
Mutation can also occur during cell division (mitosis) without trigger, because of errors in creating new copies of the gene, the probability of this kind of mutation is directly proportional to the number of cell divisions (mitosis).
I used artificial sporozoites because they are going to make or increase the number sporozoites themselves, in-vitro.

Mutation always occurs when there has been a change or error during dna replication and that’s what I meant by trigger. Mutation leading to resistance is always caused by exposure and adaptation to what has been killing the microbe.

Don’t you think if all anopheles are eliminated. Plasmodium will find a way to evolve, infiltrate other vectors and find their way in us one way or another in future. I believe this micro organism are just as intelligent when it comes to survival.

And the park managers have business with MC. So indirect or indirectly there is business going on….

Supersymetry:
From the article, they said it was difficult to make your on sporozoites in the lab, but now they developed a method to do it, so with the method they can produce as many as possible weak/inactive and strong sporozoites in the lab and the they are going to use the weak or inactive sporozoites by injecting into people so that their body will develop resistance against sporozoites, and not for other stage of the protozoa.

Then here comes the problem
1) they make artificial sporozoites in large quantities in the lab, giving room for mutation, the greater the cell population and mitosis, the greater the difference between each of them
2) introduce weak version into the body, gives room for "first/original antigenic sin". The lab generated sporozoites will be slightly different from wild species over time making the immume system having a difficult time. It might even trigger autoimmune response in some people.
3) some might escape the immume system's immediate response to form a different strain, then boom! Every anti malaria drug becomes useless.then we will have to develop a new drug which is not easy.

And your number 1 isn’t how mutation works, and artificial sporozite is not accurate. They might be Genetically modified to survive in labs or whatever but they are not artificial. And mutation does not occur suddenly, it takes a trigger like fighting off our antibodies etc. Mutation in this sense gets dangerous if a resistant sporozite finds a way in a humans body and passed its ability to other sporozite buddies through horizontal transfer.

Supersymetry:
From the article, they said it was difficult to make your on sporozoites in the lab, but now they developed a method to do it, so with the method they can produce as many as possible weak/inactive and strong sporozoites in the lab and the they are going to use the weak or inactive sporozoites by injecting into people so that their body will develop resistance against sporozoites, and not for other stage of the protozoa.

Then here comes the problem
1) they make artificial sporozoites in large quantities in the lab, giving room for mutation, the greater the cell population and mitosis, the greater the difference between each of them
2) introduce weak version into the body, gives room for "first/original antigenic sin". The lab generated sporozoites will be slightly different from wild species over time making the immume system having a difficult time. It might even trigger autoimmune response in some people.
3) some might escape the immume system's immediate response to form a different strain, then boom! Every anti malaria drug becomes useless.then we will have to develop a new drug which is not easy.

You are right about the ability of the sporozite to mutate. Which will be another problem in the future.
And yes plasmodium itself has been mutating and getting resistant through the years. That’s why there are different compositions in different malaria drugs and it is advisable to switch from time to time.

The best thing is to eliminate all anopheles but I am a huge biodiversity advocate and it’s hard. But you are right. Eliminating the vectors could just end it all.

Supersymetry:
In this case what matters is the "gene" and surface protein. not the life stage, the sporozoites stage will even gather resistance faster than matured plasmodium, because the transposable elements/ genes are more expressed, can't go into details, it's a deep complex topic.
And one thing you should understand about scientific research today is that, the people that funds the research instruct the researchers on the what outcome they want, unlike early days of scientific research were the scientist determine the direction of the research,
I can't go into details. That's why there are many conflicting scientific publication today.

Europeans always bring greek offer, check their history.

I have to read more on the ability of sporozites to gather resistance fighter but for you to under what I was talking about with life stages or life cycle. Here is a picture

And I guess since this is an African issue, research should be carried out by Africans to remove fear. But I don’t think we are there yet. Requires funding, electricity, equipments and technical expertise then clinical trials.

ConfidentialDoc:
I agree malaria is a big issue but let the research be done by ethical and sincere scientists for the good of all, and not fall into the hands of the profit-hungry eugenecists !

Yes. It should be done by African scientists but are we there yet?

correctguy101:
You say wetin? Where the road pass?

Some people are always high on politicians urine.

Please I don’t see any roads or is it just me?

Where are the roads? 613million sorry billion.

Jesus F Christ, are these people kidding. Where are the fucking roads?

Supersymetry:
That's what they told you, eliminate mosquitoes ( i mean the blood sucking species) the ecosystem will adjust, after all 95% of all species on Earth are extinct , the ecosystem didn't collapse.
Putting pressure on plasmodium will make it to start rapid mutation, which may lead to new strains,
In biology the higher an organism is, the more difficult it is to kill it by vaccine, because the have many genes to adapt and change, protozoa is higher than bacteria which is higher than viruses, so ask yourself why hasn't be any vaccine for bacteria but they're planning to introduce one for an organism higher than it, an organism that undergoes rapid surface protein changes the reason it's difficult for our immune system to fight it, hence expecting a permanent or single vaccine to cure it is speculating on mirage, so expect them to introduce new vaccine every time after the plasmodium acquire a resistance against it, more like advanced malaria periodic injection. By then all the anti malaria drugs will be ineffective.

I like your reply. And I now understand your fear which stems from resistance and the fear Plasmodium will change to superbugs.

But looking at this innovation. Their method is not to develop vaccine for the matured Protozoa, but the sporozite which is like their zygote phase for human.
Sporozite can’t mutate or evolve because the have to grow and pass through life cycle stages.

Their goal is to develop vaccines that produce antibodies that fight the sporozite and kill them before they mature into the plasmodium that causes malaria. Sporozite are like the egg form and I believe don’t cause malaria until the cycle reaches PF that breaks down blood.

I believe this is not what to fear. Lifecycles is one of the factors that determine how we combat a microbe. Which also determines how difficult it is to eliminate

HomeTutorsPro:
Read in between the lines and you'll understand my assertion.

Malaria is already depopulating Africa. Do you know how many infants die every day from it? Let’s not go into adult.

Do you know malaria is the cause for the genotype matching Wahala we have in Africa?

Supersymetry:
Total eradication of mosquitoes is the only effective way to end malaria, other methods like vaccine can't be reliable because the protozoa will evolve a resistance against it faster than it will against direct chemical approach currently used, there by making the current chemical less effective.

Wrong! All animals including mosquitoes are important to the ecosystem. What you would have said is the eradication of the blood suckers but they also have their use. If you doubt, make your research. Vaccine is the best, especially if it a one time vaccination type.

HomeTutorsPro:
Long story short:
They can now produce malaria in the laboratory.
This more bad news as it is good news.
Watch as Bill Gates and his gang will "donate" to the production and distribution of the vaccine so they can buy it over and turn it to a lethal weapon of depopulation against Africa.

What the hell are you on about?

This is wonderful. Someone is getting skeptical about this great work of science. Since our body could not generate antibodies against the developed protozoan that causes malaria. Would it develop antibodies against the sporozite?

I just admire the brilliance of science and scientists

Sheistoopretty:
That's not for Nigerian men, Nigerian men can be Poverty-stricken and still giving birth to children like rabbits

Just take a look around u, isn't it poor men who are having majority of kids? If u had said foreign men, I will understand

Nigerian men are just Us*less.......all of them

Hmm. It takes two to birth multiple children in poverty. So both men and women are useless. Don’t be partial.

Saintmary:
I can't believe some people can be so selfish.

It is human nature.
Some day, I hope I’ll be able to lead a long term experiment and research about sickle cell and ways to cure it through Gene knockout technology which is vast expanding through biotechnology. It’s a pity we depend on faith rather than science in Africa.

Only we Africans can help each other.

African swine fever also do not have a vaccine because it is an African disease. The normal swine fever has a vaccine

just2endowed:
ypur number 2 caught me, why is the disease common in Africa? was it from cross breeding from another species of non Homo sapient?

Because our DNA mutated/evolved to give us the S gene so we can battle malaria. So we wouldn’t die easily and be wiped out from malaria. AS genotype is resistant to malarial.

Globalistic:
Follow your heart brotherly.

I am AS and got married to AS. By the special grace of God, our two kids genotype are AA and AS. At the moment, we have stopped raising kids because God blessed us with two healthy boys.

For me, my advise to you is that if your faith isn't large like mine, go for AA.

God will guide and bless your decision.

What tha hell? And if things didn’t go as planned per your “faith”. You will subject those kids to pain for their entire life.

This is the most foolish advice. He can only follow his heart if he has money to take active precautions.

kay29000:
Whoa! I never knew this. Let me do some research.

Don’t mind him. White people also carry the sickle cell trait and can have sickle cell anaemia. But it is rare

ecolime:
They can't survive outside of Politics. That's the only job you get paid for doing little or nothing. Useless bunch of opportunists.

This is why the upcoming election is The political elites (that wants to stay in power by all means) VS The suffering, oppressed masses.

Anyone still want to vote pdp and apc in any political level is either a fool or has something to gain!

Hassanmaye:
What of those that like too much like Toto?

I’ll rerepeat what he said. If you want to live long. RUN O. Avoid them.

hopefulLandlord:
Would you be so kind to tell us the chemical that would knock someone out so fast?

Ever done fentanyl? Little, like a drop is enough to make you pass out in 3secs for hours. Plus you can easily overdose and die if not careful.

And yeah, people use it to get high

Kajaard:
Shut the fvck up

What is really wrong with you people? Someone just died and you are using that opportunity to write this?

Why not just say R.I.P or just shut the fvck up if you have nothing better to say? Terrible nauseating human beings

Don’t be surprised. The religious ones are sometimes the most wicked and insensitive humans.

A lot of Nigerians are criminals and love stealing. They won’t hesitate to steal from their country man talk less of a foreigner.

Buying and selling of stolen items is a huge business in this country. I have started becoming over conscious whenever I am around fellow Nigerian strangers.

A lot of Nigerians will be smiling to this news and making unnecessary cruise not knowing he is INDIRECTLY CALLING ALL NIGERIANS THIEVES.

Richardonald:
Imagine calling PDP flag off show of shame, where as is party has been prosponing their campaign kickoff why is Apc always waiting for other party to start anything meaningful, before their dead brain tell them what to do, are they clueless

I haven't met anyone supporting Apc or Tilumbu that is normal, even is clueless agbadorian on this forum are nothing but mumu

I wonder what pdp and apc will campaign with. Especially apc, what do they want to promise us again.

Bunch of clowns

LeoDeKing:
Chimaroke Nnamani said Tinubu has no health challenges, pls what are saying?

Who believes the word of a known thief?

Are you a criminal?

So this thief can still show his face and talk in publicly. Thieves like Chima role should be shown the Chinese treatment to serve as a deterrent to others.
Shame on Efcc. FBI has been doing their job.

How much did FBI said this thief stole again?