kay9:


I agree. Both himself and the wife, in fact.

But mehn, he needs to be careful and really wise here - what if the wife is telling the truth? I must be honest here though, from my limited knowledge of these things it is IMPOSSIBLE for a carrier and a non-carrier to produce a sickler - Mendel's laws of genetics would have to be rewritten. But you know what they say, never say never.

Now that I think of it, the gender of a foetus is dependent on similar genetic laws: the man gives one from his (xy) and the woman gives one from her (xx), so the offspring is either (xx) x-from dad and x-from mum, or (xy) y-from dad and x-from mum. But every once in a crazy while, an (xxy) or something weird like that is produced, and that's how you get hermaphrodites. So... oga needs to be careful with his decision. By the way, has the woman ever given him cause to doubt her fidelity? One doesnt just throw away a 10-yr-old marriage like that.

God bless you!

Ever heard of Two Men who fathered a child from 1 woman. I read d article sometime last year. Two men were sexually involved with a woman, and it's proven both were responsible for the pregnancy resulted, genetically. So I think this woman fidelity status needs to b thoroughly checked...Buh, I may say here that we are dealing with anoda medical misery here! AA + AS producing an SS.

The guy should check his genotype again since the DNA proves that he is the father of the girl. Since the wife is AS the guy also should be AS as it is absolutely impossible for a couple with AA and AS genotype to give birth to a sickcle cell carrier (SS) genotype. It will never happen unless something is wrong somewhere or both parties are not saying the truth.

kay9:


I agree. Both himself and the wife, in fact.

But mehn, he needs to be careful and really wise here - what if the wife is telling the truth? I must be honest here though, from my limited knowledge of these things it is IMPOSSIBLE for a carrier and a non-carrier to produce a sickler - Mendel's laws of genetics would have to be rewritten. But you know what they say, never say never.

Now that I think of it, the gender of a foetus is dependent on similar genetic laws: the man gives one from his (xy) and the woman gives one from her (xx), so the offspring is either (xx) x-from dad and x-from mum, or (xy) y-from dad and x-from mum. But every once in a crazy while, an (xxy) or something weird like that is produced, and that's how you get hermaphrodites. So... oga needs to be careful with his decision. By the way, has the woman ever given him cause to doubt her fidelity? One doesnt just throw away a 10-yr-old marriage like that.

They talking about genotype, not chromosomes.

gmemdee:
I think the problem is with the genotype tests. What I suspect (and this is conjecture) is that girl is not SS but SC and that the father is not AA but AC. My experience is that most Nigerian labs cannot correctly identify AC and SC genotypes. My reco will be for them to seek out a respected lab to redo the genotype tests for the Father and daughter.

this is exactly my thought. There's a thin line between AC and AA, and SC and SS.

Demichaels:
My friend's 10 year Marriage is about to collapse.

His, my friend's genotype is AA and his wife's genotype is AS but their 4 year old daughter has been confirmed to have SS genotype by not less than 4 different medical experts. He confronted the wife and accused her of infidelity but she vehemently denied having any affair with another man. In other to prove her wrong, my friend subjected the little girl to a paternity test and there he got the shock of his life - the result showed he actually is the father of the girl. At first he accused the doctor of compromise because he is their family doctor and somehow relates to the wife. He then decided to go to another hospital to prove the paternity of the girl child there and then he got another shocker - the first result was actually correct. As It stands, my friend has consulted more than five other doctors outside the state of his residence and all Confirmed that the girl's genotype is SS and he actually is the father of the child despite his and the wife's genotype being as stated above. Even the doctor's are confused by the results as it negate conventional medical norm.

My question now is, experts in the house, is there anything that can lead to such unconventional biological flaw? Under what condition can AS and AA couple have an SS child? Can mutation lead to such condition? My friend insists on divorce because he doesn't believe the wife. Should he go ahead based on what we all know about genotype?


Please I need matured advice on this. This is a REAL LIFE SITUATION AND NO FICTION. I WOULD HAVE MENTIONED NAMES AND ADDRESS OF THE COUPLE BUT I DON'T HAVE THEIR PERMISSION YET. THIS IS HAPPENING RIGHT HERE IN PORT HARCOURT OLD GRA WE'RE LIVING

DNA for final confirmation has been done. Hope the baby was not switched at birth sha. A DNA should be done on both he and his wife esp if she was faithful to him. Cos in the end, the baby may belong to none of them. That is to say......baby was switched at birth. This should not be about the husband alone. Naija men can be selfish sha, all I see is him worried about himself. What about the poor wife? What if she was as worried as he is? Biko tell him to first prove that baby at least belongs to wife first, then he can worry about if its his or not.

donLEXY:
It is not 100% impossible, though extremely rare. And we need to know how old the baby is at the time of testing. Let us assume all test done are 100% correct, the only thing I can say about the situation is that the baby got two S gene from the mother( when you talk about mendel's law of inheritance, we always have exceptions to the rules). Hemoglobinapathie is more common in West Africa and Asia. All other phenotypes are c,d,e,o and probably three more that I canno remember @ heart (pls don't tell my professor lol), some are further divided into different cities where they were found like HgDharlem. Collect blood samples from all three of them in an Heparin tube and send to an Hematology lab going to agbabiaka community hospital and lab will not help in this case

It's always refreshing to read an intelligent post. Thanks

Demichaels:
My friend's 10 year Marriage is about to collapse.

His, my friend's genotype is AA and his wife's genotype is AS but their 4 year old daughter has been confirmed to have SS genotype by not less than 4 different medical experts. He confronted the wife and accused her of infidelity but she vehemently denied having any affair with another man. In other to prove her wrong, my friend subjected the little girl to a paternity test and there he got the shock of his life - the result showed he actually is the father of the girl. At first he accused the doctor of compromise because he is their family doctor and somehow relates to the wife. He then decided to go to another hospital to prove the paternity of the girl child there and then he got another shocker - the first result was actually correct. As It stands, my friend has consulted more than five other doctors outside the state of his residence and all Confirmed that the girl's genotype is SS and he actually is the father of the child despite his and the wife's genotype being as stated above. Even the doctor's are confused by the results as it negate conventional medical norm.

My question now is, experts in the house, is there anything that can lead to such unconventional biological flaw? Under what condition can AS and AA couple have an SS child? Can mutation lead to such condition? My friend insists on divorce because he doesn't believe the wife. Should he go ahead based on what we all know about genotype?


Please I need matured advice on this. This is a REAL LIFE SITUATION AND NO FICTION. I WOULD HAVE MENTIONED NAMES AND ADDRESS OF THE COUPLE BUT I DON'T HAVE THEIR PERMISSION YET. THIS IS HAPPENING RIGHT HERE IN PORT HARCOURT OLD GRA WE'RE LIVING

Paternity tests results come in percentageof ssimilarities. 80% matching is a generally accepted pass mark. The brothers and first cousin mostly have strong match with a man's offspring because they are genetically strongly similar .

OP advice your friend to divorce that woman for she has fathered a daughter with his brother or male cousins. That child is not his although the paternity test shows a pass mark. It belongs to one of his AS brothers or cousins.

Alternatively

let them go for a dna test. That one is more expensive and more reliable.

Behira:
yea it can but the possibility is very slim

pls xplain,maybe we hv 2 ignore mendels law of genetics.

Mtcheew. Did it not occur to them that the man should repeat his own HB genotype test? U can always have wrong HB genotype test results.

AXYZ:


I think this can only be explained spiritually and not biologically. Many at times I have heard testimonies that God changed their probable SS child to AA miraculously as much as He changed a probable girl to boy (after much prayers) or vice versa.
His ways are not ours.

so God wil change an AA child to SS?dnt fink xo our God is nt a wicked God. .

MarvellousGod:
The woman don go away match

Meanyl, they need to ascertain the authenticity of the tests... maybe have them redone. ..

guy read the post well.

femi4:
Its impossible, both of them are AS, they should just divorce. The man is lying, he is not AA

didnt u hear the man and his wife ran another test to confirm dre genotype again. . .wat else do u wnt them 2 do?

helo aus. It is possible. Its either d mans AA genotype has a recessive S gene. Or d womans S is very dominant.

oyin17:



sugar what is it?

Oyin sweetie,the guy wrote us here in 2013 that he was having issues with his SS girl friend, and later wrote on here today that he has the same problem of given birth to SS baby..

The mother, father and the child should do a quantitative genotype (HB electrophoresis). It will show the quantity of the A, S or any other abnormal cell like C etc. That can help doctors to understand the situation better.

MzJackBaueress:
They should have a DNA done.
Simple!

they ve dne that ma. .read the post again. . .berem

chimkaire:
...are the Doctors on this Forum asleep, presently

lemme call draify. . Oya wre u @?

I've a funny feeling that the man's genotype is not AA, he appears to not have decided to retest himself. I believe he is either AS or AC. He seems to really want to divorce his wife very quickly. That's highly worrying, since it implies he has some serious trust issues with his wife. I've no idea if the man himself is rather dodgy, he just seems to want to end the situation very quickly.

It's amazing how some people on NL seem so eager to scream infidelity at the wife, even though the story says the family have had more than one DNA test that confirms the man is the father. Nowhere has it been pointed out in this story, that the man has officially confirmed his genotype as AA.

The human body is a funny thing, mutations are known to happen, if it has been confirmed that he is indeed AA, then it could simply be a rare case with the child. But know this, after the smoke clears, his wife will find it very hard to trust her husband, since his behaviour will definitely bring fresh doubts into her mind.

Malawian:

both my parents are/were AA, one of my sisters is AS, one of my brother is SS, his twin is AA.
dont come and start talking about what you dont really know about.

You should have said both your parents are O and all the kids are AA bloodtype.

why am i finding it difficult to believe this story?

tpiadotcom:




You should have said both your parents are O and all the kids are AA bloodtype.

do you even know the difference between blood group and genotype?

ggrin:
Hope say nob k ingtom be d doctor's sha



Better carry ya pikin go better hospital

Ketekete Oshi! Ode ni e, Kabuki ni e! Opolobaby! Opolo oshi ni e! Ode ido, o ra dodo ni ido, o je dodo ni ido, o wa fi owo dodo pa omo oni dodo ni idodo!

It is very possible,my dad is AA and also my mum but am AS among 4 children(am d 3rd child)and ve done d test 3x now is still d same

Guy, it has happened to me. It is possible. I am AA and my IGR is AS, but our boy is SS. Now let me explain. It has just been discovered that the sickest cell has other straints of AS that if combined with AA, will still produce SS. I went as fact as doing a DNA test for our son, and the doctors in a hospital in America, where my wife gave birth, conform d this.

arsetalks:
Some of you are just daft. Imagine the mystery of the father right now and he then reading this nonsense form you. You need a head transplant. A brain transplant won't be enough. Your complete head needs to be changed.

Oponu afofun gbemu

Dang!!!! You really need to take a chill pill....

impossible...

As far as am concerned, knowledgbl of. It cannot happen under normal medical situation.
The only twist to this is the man not being AA. I once had a case that made me recheck my blood genotype. Am AA but do u believe the technologist couldn't differentiate the serum shape. She has to come show the boss the slide who chided her saying this is AA. She was about writing AS on the result paper.
Secondly is the wife. Is she sure d man is the father of the child or the man's brother. I wish them d best in unravelling this mystery but please they should take care of the gal. SS are also human beings to be loved. They are in DAT situation for no fault of theirs. Thanks

Demichaels:


Yes. The wife inclusive

there must have been a SS in the man's family,kindly check for that

pbs4real:
lemme call draify. . Oya wre u @?

hmmmmmmmm

Demichaels:


They have done that severally

There is also a rare genotype 'AC' wit similar crises as 'SS' but in dis case, with special medical care, the child outgrows it b4 the teen age.
Only an experienced pediatrician & reputable hosp can diagnose it.
Go to National hospital Abuja. I ve witness a child with dat case & Dats wer I knew dat genotype 4d 1st time.
NB: some gynaecologist with obsolete scanning nmachines still confuse Adenomyosis with Fibriod & end up opening someone up just to find nothing cos unlike Fibriod, Adenomyosis is just d thickening of d external linning of d womb & not an attached growth in d womb(fibroid)