Toneyo:


Things really got messy last year. I stopped eating her food not because of the genotype issue. I dont sleep on same bed with her again nor make love to her. I said in my earlier statement, I said lots of discoveries later came up.

I have my little penthouse I stay, but do return home cause of the kids, like 2 or 3 times a week. I dont want to go into details, especially on social media.

I had to make a statement on this particular issue cause it is just like my story/experience. I almost lost that boy. You wont believe my wife refused me to take him to the hospital when he was in a serious crisis? She said it was a spiritual attack from my village.

That was the prophecy and revelation given to her in the church. It took courage, wisdom and patience to convince her to let me take him to hospital. She was so adamant and wouldn't let me take him.

Hmm, her saving grace was that she was 7 months pregnant, because I couldn't bear it anymore seeing that little innocent boy in pains. For almost 48hrs she refused to let me take him to the hospital.

God knows if it wasn't for her condition then, the devil would have used me to cause serious havoc on her, because I was already loosing my mind but due to that I'm a very patient person and do tolerate a lot.

God knows how it hurts me to see my home crumble, but for peace to reign, I had to leave home and get another place because I couldn't her nags anymore. There are to my story, but I wont go any further.

Oga calm down. Your wife may have the same case as we are having here which is beta thalasemia. So, don't just conclude and wreck your family yourself. Take her to a very standard hospital/laboratory preferably teaching hospital and get her tested for beta thalasemia. Then you will know what really happened.

Forget all the negative talks of myopic nairaland people. My strong advice.

pragmatistm:
Oga calm down. Your wife may have the same case as we are having here which is beta thalasemia. So, don't just conclude and wreck your family yourself. Take her to a very standard hospital/laboratory preferably teaching hospital and get her tested for beta thalasemia. Then you will know what really happened.

Forget all the negative talks of myopic nairaland people. My strong advice.

The problem with Nairaland folks is not just ignorance but the refusal to unlearn and relearn.

The explanation is simply enough: the woman (AA) passed a beta thalassemia gene to the child, which makes the child (though AS genotype) to manifest sickle cell anemia (SCA). Ordinarily, AS don't manifest SCA, but in the child's case, the beta thalassemia gene rendered the A hemoglobin inactive, so only the S hemoglobin was producing. The end result is an AS child manifesting SCA, as though he's an SS.

studentofTruth:


The problem with Nairaland folks is not just ignorance but the refusal to unlearn and relearn.

My brother, thanks for the insight you provided on this matter. God bless you. See how people are calling someone they don't even know evil. Even calling me evil because I'm defending her. We are Christians and close family neighbours and someone from nowhere that dont know us is even cursing us. Even raising all sorts of nonexistent theories like she is fucking out, she went to pastor to change AS to AA for her, etc.
How bad people can be!

Now I now have better information. I gather from her discussion with my wife new angle to it. I think in one of the initial tests she has been informed of beta thalasemia in her blood but because she did not understand as a young girl, she started going to other labs for retest and others gave her the AA results.

pragmatistm:
My brother, thanks for the insight you provided on this matter. God bless you. See how people are calling someone they don't even know evil. Even calling me evil because I'm defending her. We are Christians and close family neighbours and someone from nowhere that dont know us is even cursing us. Even raising all sorts of nonexistent theories like she is fucking out, she went to pastor to change AS to AA for her, etc.
How bad people can be!

Now I now have better information. I gather from her discussion with my wife new angle to it. I think in one of the initial tests she has been informed of beta thalasemia in her blood but because she did not understand as a young girl, she started going to other labs for retest and others gave her the AA results.

You see: In the thread I created to explain the case, I made mention of being aware of a possible hereditary blood disorder in her lineage but unknowingly assuming it's SCD — the reason for her repeat genotype tests.

alexola20:
What are you even talking about?
Are you the woman?
Are you the husband?
Are you the sickle celled?
Nobody ever does genotype test for 7 times even HIV sef when the person no be randy person.

First time in the world.
7 times genotype test.
Haba.Even Dangote won't go for that many times.


But after her child is confirmed an SS,she herself now suddenly becomes an AS.

(in officer Woos' voice)Oooooggga mi...Tualeee

. Please read my edited post on front page on why she went as far as 7 tests and learn. Thank you.

studentofTruth:


You see: In the thread I created to explain the case, I made mention of being aware of a possible hereditary blood disorder in her lineage but unknowingly assuming it's SCD — the reason for her repeat genotype tests.

Three Gbosa for you my brother. Thanks so much.

Let all self-righteous people here come and learn.

pragmatistm:
Three Gbosa for you my brother. Thanks so much.

Let all self-righteous people here come and learn.

The gbosa is not necessary. My annoyance is that the people we're trying to enlighten, don't want to be enlightened. I have tried to explain it with different grammar, but they aren't having it. I leave them to their ignorance!

PrimadonnaO:


Whose results remained constant? Mine or hers?

For me, I strongly believe that there's something about this genotype testing that is yet to be unraveled by scientists.

If I had gotten married on my last AA result, I'd have been in trouble... and this is how people would have been doubting that I had done proper checks.


I've generally become very skeptical about lab results when it comes to genotype issues, so I can no longer categorically say someone is lying. I agree that 7 constant results suddenly changing at the 8th is very peculiar, though.

Whenever you want to run any test in Nigeria, go to a standard lab and always insist that only qualified lab scientists run your tests. Not so called "technicians" nor even technologists. Sometimes we neglect professionalism in Nigeria but it matters.

In this genotype test for instance, the test sample is usually matched against a standard AS blood. When the machine is switched on, current flows through the cellulose paper bearing the samples and cause the A and S hemoglobin to separate. If the individual is AS, it will be very clear because the A and S of test sample will be moving along same line with that of standard. If the individual's blood is AA, it will not separate while only the standard AS will separate. The test blood will be on same line with the A portion of the standard which will be moving faster than the S portion which usually lags behind.

It takes some expertise to pinpoint when it is AA, AC or SS but AS is not so difficult to identify since it usually moves like the standard.

Chii59:

Just checked his profile now. Seems this story is fake and a ruse to sell his meds. Stc30 DOESN'T cure Sickle Cell people! Don't be scammed.

He was busy disrespecting anyone who cared for a bit of clarity in the stupid fable he brought for discussion, scammers everywhere dear.

All comments read so far are batter, no scientific explanation so far! Happy Sunday. Maybe she was prayed for in one prayer house, den boom, it happened!

If I may ask, God created only two people on earth, and how come all of these?

Jman06:
Whenever you want to run any test in Nigeria, go to a standard lab and always insist that only qualified lab scientists run your tests. Not so called "technicians" nor even technologists. Sometimes we neglect professionalism in Nigeria but it matters.

In this genotype test for instance, the test sample is usually matched against a standard AS blood. When the machine is switched on, current flows through the cellulose paper bearing the samples and cause the A and S hemoglobin to separate. If the individual is AS, it will be very clear because the A and S of test sample will be moving along same line with that of standard. If the individual's blood is AA, it will not separate while only the standard AS will separate. The test blood will be on same line with the A portion of the standard which will be moving faster than the S portion which usually lags behind.

It takes some expertise to pinpoint when it is AA, AC or SS but AS is not so difficult to identify since it usually moves like the standard.

Hehehehhe. Technical explanation. Thanks.

Our knowledge is really limited in this part of the world. Her husband is AS and she is a beta thalassemia carrier a bad combo. These were seen as early as possible but was either not properly explain to this lady or it was but religiously disregarded as unimportant.
Now their baby will suffer the bouts of a sickness that is too alien to Nigerians.

People affected by sickle beta thalassemia inherit a different mutation in the HBB gene from each parent: one that produces sickle hemoglobin (called sickle trait) and a second that results in reduced levels of functional hemoglobin (called beta thalassemia).

When two carriers of an autosomal recessive condition have children, each child has a 25% (1 in 4) risk to have the condition, a 50% (1 in 2) risk to be a carrier like each of the parents, and a 25% chance to not have the condition and not be a carrier.

Get a haematologist and a medical laboratory scientist with specialty in haematology to unravel what really transpired and also to receive proper treatment.

Its practically not possible for all the seven labs both government and private to have all made same mistake. but it is possible that

1. All the result may have been doctored to convince the husband out of desperation for marriage
2. The new test done after birth may also be wrong.
3. The husband may not be the father of the child
4. The baby might have been replaced at birth

Blood group and DNA test should first be done to confirm its their child.

After that they both should go for another genotype test at another lab. if the husband can remain AA the the result of the wife should be final.

There is no way someone who is AA will turnout to be AS all of a sudden.

The story is not complete, running genotype 7 times from one lab and hospital to the other and all came out AA , and she was still confirming. No I don't think so. Maybe some of the test came up as AS and other AA (mistake) , that must have made her to repeat and repeat. The only thing she could have done was to go to one of the ISO accredited labs in town and confirm it. These genotype and blood group errors are not perculiar to Nigeria, even in the U.S it happens.
Of course I have handled a case a client came with an AA genotype result from the Atalanta, U.S, Eventually we confirmed it to be AS at one of the ISO Lab here in Lagos, she couldn't believe it. Sample was sent to South Africa on her request and came back AS. So it's not perculiar to Nigeria alone.
Always check ISO accredited Diagnostic Labs for confirmations.

Verysmart101:



Cheap scammer like you.

I came here to enlighten people on what most of them are ignorant about and also provide hope to Sickle Cell Patients through first hand experience I have had with them and to God be the glory ...their Genotype have Changed after being on our Therapy....Yes...I said it and will continue to announce it to the World and you mentioned me with that rubbish up them.

Today being Sunday, the 31st day of January 2021, I use your hand written statement as a point of contact and I place you on a CURSE. May the CURSES of my GOD from His word in the book of Deuteronomy 28 from verse 16-68 rest upon you head NOW for that utterance you made in JESUS mighty name I have prophesied (AMEN).

That will teach you a big lesson that it's not everyone you make such allegations to.

Jman06:
Whenever you want to run any test in Nigeria, go to a standard lab and always insist that only qualified lab scientists run your tests. Not so called "technicians" nor even technologists. Sometimes we neglect professionalism in Nigeria but it matters.

In this genotype test for instance, the test sample is usually matched against a standard AS blood. When the machine is switched on, current flows through the cellulose paper bearing the samples and cause the A and S hemoglobin to separate. If the individual is AS, it will be very clear because the A and S of test sample will be moving along same line with that of standard. If the individual's blood is AA, it will not separate while only the standard AS will separate. The test blood will be on same line with the A portion of the standard which will be moving faster than the S portion which usually lags behind.

It takes some expertise to pinpoint when it is AA, AC or SS but AS is not so difficult to identify since it usually moves like the standard.

@bolded Is electrophoresis still the only method used for genotype. Asking because these days there seem to be machines that do everything.

since it brough out AS this time why did she stop doing the test? she should continue with more test it will chance back to AA

Munzy14:

Yes... I feel OP is just telling another story.

If love is that strong, they should av opted for adoption, and forget getting pregnant.

If this story is true, the lady played the guy big time..But, the consequence is general something she didn't think of ahead.

If they are not financially OK, I smh for them.

There's one interesting comment I read on that thread.
The guy and his wife (formerly girlfriend) took a huge risk and got married, despite knowing they were both AS.

NoToPile:


@bolded Is electrophoresis still the only method used for genotype. Asking because these days there seem to be machines that do everything.

Yeah, there are other methods but electrophoresis is what's commonly used in our labs

Jman06:
Yeah, there are other methods but electrophoresis is what's commonly used in our labs

Okay Thanksss

studentofTruth:


I'm a doctor; I understand what you are trying to say. Neither you nor your brother is down with thalassemia but can pass it on to some of your kids.

I created this thread to explain the case. https://www.nairaland.com/6391907/hemoglobin-issues#98598813

Regarding your explanation, you are getting it mixed up already. Of course, it's expected since you are not a medical person. But I'm glad your brother is smart enough not to accuse his wife of paternity fraud, given that he's the one with AA while the wife is AS.

Coming to the condition itself: Beta thalassemia and SCD are 2 distinct blood hereditary (recessive) diseases that are inherited independently. For SCD, there can be AA, AS (a carrier), and SS (manifests SCA). For beta thalassemia, one can be a non-carrier (no beta thalassemia gene), a carrier (one beta thalassemia gene, like you and your brother), diseased (2 beta thalassemia genes and manifesting moderate or severe disease)

Thus, for each to manifest, the person must have both copies of the bad gene for that disease. But in some situations, a carrier of both diseases can manifest SCA — as it's the case with the child in this index case and your brother's child too — because the beta thalassemia gene stops the production of hemoglobin.

Let me explain:
The child is AS but, at the same time, has a beta thalassemia gene on one allele (gene copy). Unfortunately, it's the same allele that contribute the A component of the HbAS combination of hemoglobin. So, the normal hemoglobin A is not adequately produced. The other allele that is not inactivated by the beta thalassemia gene produces hemoglobin S, which sickles. So, the child's blood will be full of sickled hemoglobins, and the labs would erroneously tag it SS. The problem here is using a phenotypic test to make a genotype conclusion!


Coming back to what you said about AA vs. AA knocking out beta thalassemia: As I explained earlier, the AA thing is about SCD and not about beta thalassemia. Of course, AA vs. AA can prevent an AS offspring, which invariably takes away the possibility of having the beta thalassemia gene causing an AS to manifest as an SS. However, AA vs. AA can still have a child with beta thalassemia if each of those AA individuals is a beta thalassemia carrier (each has a beta thalassemia gene) because the beta thalassemia gene is inherited independently of the SCD's A/S genes!

I hope you understand it now!

You know, as my brother said, the science of blood is gradually being understood. One thing I got from it all is, as a carrier of Beta thalesemia, I should never get with AS women. In fact I usually tell women I am AS myself.

Ishilove:

And you know she is upright because...? Don't be fooled by looks. Daggers are hidden in men's smiles.

I can understand and blame inexperience for 1,2, perhaps 3 tests, but 4, 5, 6 and 7? From different labs? Puhleeze! 7 different labs, 7 different lab technicians, 7 different tests, all AA. And you believe her. If Nigerian labs were so bad half of us would be dead by now because of wrong test results.

Stop being wilfully naive.

.l doubt the woman is deceiving the house by doing the test 7 times.lt is wise if she did it the test even 20 times because the fear will be there.l know we have medical experts in this house let them come and clearify us on this issue.

.

Zico5:
That's why God is the ultimate in life. I can't call this error but just pure hands of God to show that he is the omnipotent. I married 12 years ago. I knew that I am AS but did not even bother to ask my wife for good 3 years. I was really afraid when she told me she is AS and she is ready to go along with me despite knowing I'm also AS. I wish to back off but my relatives and my pastor encourage me to go ahead. Upon advice and counter advice we eventually married . The first few years were really tense especially when I gave birth to my daughter. If u are of little faith please don't do it o. A little cold like this can lead to hypertension. I promise God that if the second child is a boy I won't give birth again. Thank God he is a boy. The boy was sick last year and my wife secretly did their genotype without telling me. I was really afraid cos she kept the results for six months. I instantly asked her to bring it "Eekan lomokurin nku". Though I have no fear about the first daughter because she is already 10 and in JSS 2 class but I'm afraid for the boy. Low and behold I opened it. They are both AA to God glory. Well, my advice is that don't try it if ur faith can carry it. But I think some situation is better left to God to handle. Error can happen here and there. As well, what will u do if ur child is deaf and dumb. May God almighty guide us right.

I wonder the kind of help your pastor and family members would have given to your children if they had turned out to be SS. You took a huge risk on innocent kids

OneCallAway:


I see you'd stop at nothing to pin the fault on the man....why? your hate for men or what? initially u said his genotype wasnt stated and he could be the one at fault....now he could be SS so its still his fault....Even if he is SS and the woman is AA as she had put it, there's still no way they'd have an SS progeny....just educate yourself and dont be a bloke....do u even need a test to know one who's SS?....most of them dont even make it to marriageable age...

You can't teach me about genes, as I know about it. Everyone has done this in biology class. The issue is the nature of the story. Who is to say the man isn't actually an SS, since it is full of changing genotypes? Since he believes that after 6 tests, on the 7th it magically became an AS for his wife, he could easily not know his own genotype since he only did his once.

I don't hate men. But I'm noticing a trend on topics brought up on nairaland by a person/persons who hate women. What is the aim of this article?

OP dy use us catch cruise.too descriptive like it happened to you.dem show you d 7 lab results?

TemmyT002:



Only believe if you see the results of the previous 7 tests. I mean the hard copy

Too bad, result can also be altered

No body is taking about the sick child, for me I just want to chip a general advice to those suffering from SS stay away from processed sugar this is from speaking from experience

[quote author=pragmatistm post=98589273] She felt she might not be AA because she does not often fall sick of malaria like it used to happen to most AAs. That's why she did it repeatedly before marriage.




Hmm... what you said here is a huge fallacy. AS are the ones not prone to having Malaria, since the morphology of their Red Blood Cell does not support thriving of malaria parasite. The actual reason for the existence of the Sickle Cell trait is that african body system developed the trait in order to adapt to the perenial Malaria diseases. Hence, for her not have fallen sick all this while when her siblings do is a huge indication that she is AS .

Why confirmation for 7 times?