₦airaland Forum

Combining phototherapy with chemotherapy may provide a more powerful approach to combat aggressive tumors effectively.
Patients with late-stage cancer often have to endure multiple rounds of different types of treatment, which can cause unwanted side effects and may not always help.

In hopes of expanding the treatment options for those patients, MIT researchers have designed tiny particles that can be implanted at a tumor site, where they deliver two types of therapy: heat and chemotherapy.

This approach could avoid the side effects that often occur when chemotherapy is given intravenously, and the synergistic effect of the two therapies may extend the patient’s lifespan longer than giving one treatment at a time. In a study of mice, the researchers showed that this therapy completely eliminated tumors in most of the animals and significantly prolonged their survival.

“One of the examples where this particular technology could be useful is trying to control the growth of really fast-growing tumors,” says Ana Jaklenec, a principal investigator at MIT’s Koch Institute for Integrative Cancer Research. “The goal would be to gain some control over these tumors for patients that don’t really have a lot of options, and this could either prolong their life or at least allow them to have a better quality of life during this period.”

Jaklenec is one of the senior authors of the new study, along with Angela Belcher, the James Mason Crafts Professor of Biological Engineering and Materials Science and Engineering and a member of the Koch Institute, and Robert Langer, an MIT Institute Professor and member of the Koch Institute. Maria Kanelli, a former MIT postdoc, is the lead author of the paper, which appears in the journal ACS Nano.

Patients with advanced tumors usually undergo a combination of treatments, including chemotherapy, surgery, and radiation. Phototherapy is a newer treatment that involves implanting or injecting particles that are heated with an external laser, raising their temperature enough to kill nearby tumor cells without damaging other tissue.

Current approaches to phototherapy in clinical trials make use of gold nanoparticles, which emit heat when exposed to near-infrared light.

The MIT team wanted to come up with a way to deliver phototherapy and chemotherapy together, which they thought could make the treatment process easier on the patient and might also have synergistic effects. They decided to use an inorganic material called molybdenum sulfide as the phototherapeutic agent. This material converts laser light to heat very efficiently, which means that low-powered lasers can be used.

article continues in next post

Sladem05:
Bro didn't want to accept that blacks are a failed race.

You say these things because you've probably never received the beatdown you truly deserve. But don't worry, there's always another day.

In the meantime betweentime, just know that your country is a rape capital covered with shit, most people don't care you exist, and your dick is the size of a cashew.

I love her sense of humor.


https://www.youtube.com/watch?v=kCGuFfH7CEM

When you're ready to romance by the beach under the moonlight, or just be emotional for no reason.


https://www.youtube.com/watch?v=Fv-KBfzoyog

When you want to turn up for no reason, like snatch your shirt off and dance on your neighbor's car.


https://www.youtube.com/watch?v=nySC3VswPEE

The less educated a black person is, the more attracted they are to lighter skin.

A Michigan worker has been accused of stabbing the president of his company in a possible 'copycat' attempted murder following Luigi Mangione's alleged assassination of the UnitedHealthcare CEO. Erik Denslow, the president of car part manufacturer Anderson Express Inc, was brutally stabbed by an employee during a Tuesday staff meeting in the company's Muskegon office, according to police. The suspect, identified as Nathan Mahoney, 32, allegedly stabbed Denslow 'in the side with a knife' at 9:30 am before quickly driving away. But police were able to catch him after about 15 minutes and he was charged with assault with intent to murder and fleeing a police officer, People magazine reported. He is being held on a more than $500,000 bond and was arraigned on Wednesday, but records did not have any plea information listed. Denslow was rushed to the hospital and underwent surgery. He is in stable condition and is expected to make a full recovery. Co-workers told police that Mahoney has a 'quiet demeanor' and no specific motive for his violent outburst has been revealed. In his mugshot, the suspect is pictured smiling. But Fruitport Township Deputy Chief Greg Poulson told News 8: 'We haven’t ruled out copycat motive in regards to this.

'I think that comes to everyone’s mind in this time. We’re going through all his social accounts, all his electronic media and trying to determine a motive for this act.' He went on to say that violence and aggression against company higher-ups 'seems to be the popular thing in this day and age' after healthcare CEO Brian Thompson was assassinated in New York City. Mangione, 26, has been arrested and charged with Thompson's murder, but has received loads of support and praise for his alleged actions. 'A psychopath was idolized and now there are going to be people emulating him,' one Instagram user wrote, speculating about a connection between Mahoney and Mangione's actions. Another chimed in: 'This is sick. It's open session on CEOs I guess. People actually think it's okay.'

One commenter said: 'People tired of working hard and their bosses getting richer and richer... not saying this is right!' The first Mangione 'copycat' is thought to have been a Florida woman who was accused of threatened her health insurer with the words Mangione allegedly wrote on the bullets that killed Thompson on December 4. Briana Boston, 42, was charged over a threatening call she is alleged to have made to BlueCross Blueshield about a rejected medical claim. Towards the end of the call, she allegedly told the operator: 'Delay, deny, depose. You people are next.' She told investigators that 'healthcare companies played games and deserved karma from the world because they are evil.'

Boston allegedly claimed she chose the words 'because it's what is in the news right now,' referencing Thompson's death. On Thursday, Mangione appeared in court in Hollidaysburg, Pennsylvania for his extradition hearing. After the hearing, Mangione was escorted out of court and flown to New York City on a private jet. Around 700 people were tracking the flight path online. The alleged murderer waived a preliminary hearing on the Pennsylvania forgery and gun charges in exchange for the prosecutor giving him a 20-page investigative report from the Altoona Police Department. At court, dozens of Mangione fans rallied outside with signs conveying support for the suspect. At least two of them were dressed as Luigi from the Super Mario Bros video game.

https://www.dailymail.co.uk/news/article-14211531/luigi-mangione-copycat-brian-thompson-suspect-arrested-erik-denslow.html

Okay, it's all fine and good to lock up drug dealers, but what are they doing about users?

It's called the start of an amazing meal.

Pop those on the grill. Maybe some suya shrimp or asun shrimp?

Or maybe that's the people SHE associates with...

Some of these people are sociopaths, and many sociopaths are created by trauma in childhood.

Some of these people are agents. See Neo-Colonialism and the Poverty of 'Development' in Africa by Mark Langan.

It's not healthy. It will have a negative impact emotionally, psychologically, and sexually. They need to understand that, and work on their health. If that's not something they're willing to do, you may need to step away from the relationship for a while.

This book is a great tool to help someone understand the problem:

The Porn Myth by Matt Fradd
https://www.nairaland.com/8167499/porn-myth

Derekmiles, you are a patient man. Wow.

https://i.pinimg.com/originals/a0/18/29/a01829db8affcd7f1068cafb8d4b5fea.gif

China executed a former official from Inner Mongolia over corruption charges totaling about 3 billion yuan ($412 million), a rare use of the death penalty for graft that comes with President Xi Jinping’s sweeping campaign to cleanse the Communist Party intensifying.

Li Jianping, the former party chief of an economic development zone in Hohhot city, was first sentenced to death in September 2022 for taking bribes, misusing public funds and colluding with a criminal syndicate. He lost an appeal in August and his sentence was then approved by the Supreme People’s Court.

The 64-year-old Li was allowed time with family members before his execution on Tuesday, according to the official Xinhua News Agency.
It is rare for Chinese officials to receive the death penalty for corruption charges. More frequently they get a two-year reprieve from execution, with their sentence commuted to life imprisonment for good behavior.

Xi’s anti-corruption campaign has ensnared a record number of senior officials for two straight years. That is on top of a widening purge in the military that has implicated a number of high-ranking officers and generals, including the latest target, Miao Hua, a long-time Xi loyalist and member of the Central Military Commission.

https://www.bloomberg.com/news/articles/2024-12-17/china-executes-former-official-in-412-million-corruption-case

Love800:
Suspect like how?

I didn't want to say anything because I'm not trying to insult anyone. But that gives me bad vibes like they're organ trafficking or human trafficking. And better safe than sorry.

The thing about that skill is that it's needed in every organization, regardless of size, and by every individual. Even if someone is getting crumbs to do a job in that area, they can still find some type of work, and the work will lead somewhere. Also, that skill makes you more than prepared to work in procurement/trading/sourcing.

And frankly, some would be wise to get online and do "virtual assisting" work as a junior accountant or bookkeeper for US/UK/CA/AU/NZ companies and individuals. With the exchange rate...that's good money.

The funny thing is that there are plenty of people abroad with finance training that complain about job options and salaries. But the simple fact is that, eventually, all of them end up with a good salary and job security.

Love800:
Okay.
This is my first time of hearing about volunteering. Is it actually true? I can teach English.
Is it only ivory coast that does this volunteering(hosting)?

Careful. That seems a bit suspect.

Op works for immigration.

This is who white people are.

And some of you actually pursue them for relationships. Disgusting.

Three more members of an organised crime group (OCG) have been jailed following the UK's largest investigation into drug smuggling. Prosecutors said they believed the gang smuggled heroin, cocaine and cannabis worth up to £7bn into the UK. Two trials - one lasting for a record 23 months - have previously resulted in the conviction of 18 defendants. At Manchester Crown Court, Sohail Qureshi and Khaleed Vazeer were respectively jailed for 25 and 20 years. Meanwhile Ghanzanfar Mahmood received a sentence of three years and nine months. Twelve other members of the gang have already been jailed.

The National Crime Agency (NCA) said the OCG illegally imported drugs more than 240 times from the Netherlands before they were distributed across the UK. Between 2015 and 2018, the gang smuggled more than 50 tonnes of h-roin, coc-ine and cann-bis. To conceal their crimes, the OCG set up a series of front companies and warehouses across Greater Manchester, Lancashire, Cheshire and Yorkshire, as well as in the Netherlands. Drugs were typically transported in consignments of strong-smelling foodstuffs such as onions, garlic and ginger.
In fact, the gang bought so many onions – between 40 and 50 tonnes a week - that it often had to send them back and forth between England and the Netherlands. During one of the trials, prosecutor Andrew Thomas KC commented: "The stench of criminality is overpowering."

The court heard Qureshi was a "high level, executive" member of the gang, reporting directly to ringleader Paul Green. Green, based in Widnes, Cheshire, was jailed for 32 years earlier this month. Qureshi played a leading role in setting up new supply lines for the gang when they began to suspect a previous plan - involving the setting up of a front company - had been compromised. Before passing sentence on the latest three gang members, Judge Paul Lawton said "career criminals" Qureshi and Vazeer had been secretly recorded at a London restaurant discussing criminal opportunities and drug smuggling. The judge said they had helped import drugs on an "industrial and hitherto unprecedented scale", causing "incalculable" harm across the UK. "What was actually being imported was misery, social degradation and, in the case of some addicts, death," he added. Richard Harrison, the NCA's regional head of investigations, said the gang had "absolutely no ethics". He added: "They stooped incredibly low and left a trail of devastation for entirely innocent people by cloning businesses and stealing identities." Crime and Policing Minister Dame Diana Johnson said law-enforcement agencies were "determined to bring these organised drug gangs to justice". She added that "our streets will be safer with these criminals no longer free to prey on vulnerable people in the name of profit". The last of the three convicted gang members will be sentenced at a later date.

https://www.bbc.com/news/articles/cm2l5207nnjo

Police say Mangione was found with a gun, mask and writings linking him to the ambush outside the New York Hilton Midtown, where Thompson was arriving for his company's annual investor conference. The New York Police Department told CBS News that there are no indications that Mangione was a UnitedHealthcare customer. Mangione, 26, remained jailed without bail Saturday in Pennsylvania, where he was initially charged with gun and forgery offenses. Altoona is about 230 miles west of New York City.

Mangione's lawyer there, Thomas Dickey, has cautioned against prejudging the case and said that his client would contest his extradition to New York. But Manhattan District Attorney Alvin Bragg said Friday that there were indications Mangione may now give up on that fight.

"We going to continue to press forward on parallel paths, and we'll be ready whether he is going to waive extradition or whether he is going to contest extradition," Bragg said at an unrelated press conference in Times Square. Hours after Mangione's arrest on Monday, Bragg's office filed paperwork charging him with five counts, including intentional murder, criminal possession of a weapon and criminal possession of a forged instrument.

New York Gov. Kathy Hochul has said she's prepared to ask her Pennsylvania counterpart, Gov. Josh Shapiro, to intervene and issue a governor's warrant requiring Mangione's extradition if he does not agree to be moved voluntarily.

Mangione's new lawyer has made frequent TV appearances, including as a CNN legal analyst, co-hosts a weekly podcast and is the legal adviser for "Law & Order." Her husband and law partner Mark Agnifilo is representing Sean "Diddy" Combs in the hip-hop mogul's Manhattan federal sex trafficking case.

https://www.cbsnews.com/detroit/news/luigi-mangione-united-healthcare-shooting-hires-karen-friedman-agnifilo/?intcid=CNR-02-0623

Luigi Mangione, the suspect in the killing of UnitedHealthcare's CEO, has added a prominent defense lawyer to his legal team as Manhattan prosecutors work to return him from Pennsylvania to face a murder charge.

Mangione will be represented by Karen Friedman Agnifilo, who was a high-ranking deputy in the Manhattan district attorney's office for years before entering private practice. Friedman Agnifilo's law firm, Agnifilo Intrater LLP, confirmed in a statement to CBS News on Saturday that she had been retained to represent Mangione.

The firm said Agnifilo, a longtime veteran of the Manhattan District Attorney's Office, served as the second-in-command for seven years under DA Cyrus Vance, in addition to serving for four years as the Chief of the Office's Trial Division.

The firm said she will not be making any statements at this time.

Mangione was arrested Monday after a customer at a McDonald's in Altoona, Pennsylvania, saw him eating breakfast and noticed a resemblance to the person being sought by police in the Dec. 4 killing of Brian Thompson in Manhattan.

article continues in next post

McKinsey & Company consulting firm has agreed to pay $650 million to settle a federal investigation into its work for opioids manufacturer Purdue Pharma, according to court papers filed in Virginia on Friday. McKinsey has also entered into a deferred prosecution agreement to resolve criminal charges, including that it conspired with Purdue Pharma to aid in the misbranding of prescription drugs. A former McKinsey senior partner has also agreed to plead guilty to obstruction of justice, according to the court papers. McKinsey representatives didn't immediately respond to phone and email messages on Friday.

Since 2021, McKinsey has agreed to pay state and local governments about $765 million in settlements for its role in advising businesses on how to sell more of the powerful prescription painkillers amid a national opioid crisis. The consulting firm also agreed last year to pay health care funds and insurance companies $78 million. The U.S. has been in an addiction and overdose crisis for decades, linked to more than 80,000 deaths in recent years. For the past decade, most of the deaths have been attributed to illicit fentanyl, which is laced into many illegal drugs. Earlier in the epidemic, prescription pills were the primary cause of death.

Some advocates say the crisis was touched off when Purdue Pharma's OxyContin hit the market in 1996. Three Purdue executives pleaded guilty to misbranding charges in 2007 and the company agreed to pay a fine. The company pleaded guilty to criminal charges in 2020 and agreed to $8.3 billion in penalties and forfeitures — most of which will be waived as long as it executes a settlement through bankruptcy court that is still in the works.

McKinsey documents made public over the years describe Purdue using the consulting firm to help "turbocharge" opioid sales in 2013, as blowback against the opioid crisis meant that the company's drugs were being prescribed less.

https://www.cbsnews.com/news/mckinsey-opioids-settlement-federal-probe/

How many of those streams were bought?

Not my food, but it's so beautiful I had to share:


https://www.youtube.com/watch?v=PZ7nWyA6w08

The Walt Disney Company agreed to settle California's largest wage theft lawsuit, costing $233 million, with Disneyland workers on Friday, according to the Los Angeles Times. The lawsuit was first raised five years ago, after the workers alleged that Walt Disney Co. ignored the city of Anaheim's minimum wage law. The settlement comes as the city in California is set to increase it's minimum wages to nearly $20.50 in the new year, and will provide back pay to the workers at the Anaheim theme park with interest dating from 2019. The agreement will be reviewed by an Orange Country Superior Court judge on January 17, before workers will then be notified how much money they can expect to receive.

More than 50,000 current and former Disney employees are covered in the settlement, and the back pay owed to those workers from January 1, 2019, to when Disney adjusted wages last year amounts to around $105 million, according to the Los Angeles Times. Peter Dreier, a professor of public policy at Occidental College and co-author of Working for the Mouse: A Survey of Disneyland Resort Employees, told the Los Angeles Times that, "The company has been stiffing ... workers for several years." "They've denied them the back pay they're owed while paying CEO Bob Iger over $31 million a year. It's only fair that workers get what's coming to them. And if the world were fair, Iger would take some of it out of his paycheck," he added. Newsweek has contacted Walt Disney Co. out of hours via email for comment. The dispute began in February 2018 when the Coalition of Resort Labor Unions released the "Working for the Mouse" survey, a study revealing that almost three-quarters of the Disney workers surveyed said they didn't earn enough money to cover basic expenses. The report's release coincided with a wage initiative, known as "Measure L," ordering companies in the Anaheim resort that receive a city tax rebate to increase minimum wage to $15 an hour.

As Walt Disney Co. negotiated pay with theme park unions and union councils, it did not adjust its employees' wages in line with the new initiative, prompting Disney workers to file the lawsuit in December 2019. The lawsuit represented 25,000 employees at the time, and alleged that Walt Disney Co. had illegally avoided implementing the wage adjustments. At the time, Walt Disney Co's attorneys argued that it did not have tax rebate agreements with Anaheim, according to the Los Angeles Times, and a judge initially agreed with the company. Per the outlet, the ruling was later reversed by a district court of appeal, on the basis that a tax rebate in a 1996 Disney expansion deal passed by the Anaheim City Council. Walt Disney Co. appealed the decision, but the California Supreme Court refused to hear the case, concluding the company's legal fight.

Minimum wages are set to increase in 22 states on the first day of 2025, and California's will increase to $16.50 from $16. There was a proposal for minimum wage to be increased even higher, to $18, in the state, however this proposal has been rejected.

https://www.newsweek.com/disneyland-pay-233m-californias-largest-wage-theft-case-2001181

That's awesome. You gotta start somewhere.

I think when it comes to the single mother issue, some people are forgetting that the amount of single mothers hasn't massively increased. There's just less hiding. Back in the day, women gave babies away, or they went away to give birth, and then their mother would raise the baby like he/she's a sibling.

I also think people are judging these women by foreign behaviors. Like another poster said, in Nigeria, there's a significant amount of single mothers that did not consent. In the UK/US/CA, the average single mother made a choice to have a baby out of wedlock. They do it because the child is an accessory to them, or to trap a man. They generally don't have respect for themselves or their child. Of course, that's not all of them. Many single mothers are totally normal women who, thankfully, didn't feel pressured/shamed by society into staying with an abusive/bum husband or who weren't forced by horrible laws. That's another major part of the single mother thing people ignore, women and their kids don't have to suffer with horrible men like before.

I feel like some people are obsessed with the single mother thing because of idiot podcasts, but they need to be looking at bum degenerate men creating these broken homes. I mean, these women aren't getting themselves pregnant. lol

But people need to stop normalizing it in general. You don't need to abuse people, but stop letting that slide.

Burn those pics. wtf lol