₦airaland Forum

holatin:
oloshi. How can you bring up your father when we are talking about a Nigerian governor You are the one who mentioned your father not achieving something big against all odds. So you are the correct omo ale tin fowo osi juwe ile baba e! Leave Fayose alone!!! Omo ale

escodotman:
oloshi. How can you bring up your father when we are talking about a Nigerian governor You are the one who mentioned your father not achieving something big against all odds. So you are the correct omo ale tin fowo osi juwe ile baba e! Leave Fayose alone!!! Omo ale

holatin:
by a bastard post i shall know myself.

I will ask my mum to tell me who my real father is.

I am omoale jatijati

Adolak:
I'm sure you don't know what you're saying. Go and do your research again and come back to edit this your post.
Who told you he has been in power for 8 years?

holatin:
he can only become a president in Nigeria when my dad becomes the CIA director in USA.


who wan vote am into aso rock ? maybe ipobian and biafrian

corisande:
I am AC. Growing up i always knew my genotype to be AA. I did about 3 genotype testing in 3 different labs and it came back as AC.

ryom:
Just to add to this as it is a very important topic. While there are other haemoglobinopathies (abnormal haemoglobins) apart from the well known and most common sickle haemoglobinopathies, these other types are not common among black Africans. Haemoglobin S and C are the types commonly found among black Africans. So it will still be VERY unusual for a purely Nigerian couple AA + AS to have an 'SS' child and should be investigated further if it happens.

peacettw:
On the contrary, I have no interest in slandering anyone and you are wrong to assume that all doctors know this.

sgtponzihater1:
I need some other contributions on this, this lady have had 2 previous babies for 2 previous men, rhesus negative, but doesn't know the blood group of the other men or the other babies, she gave birth recently, it was actually a twin pregnancy, while the leading twin survived, the second twin couldn't make it due to a difficult labour. I advised them for rhogam, since here previous babies might have been rhesus positive, the MO and matron however said they have been in practice over 20 years and the woman doesn't need it.

Lagusta:
I'm sorry for the outburst.....
Next time read my post before concluding....
Thanks

sgtponzihater1:
My guy don't say that. U should go to his school and contend his degree, we can't know it all. Among the top 3 causes of death in a research done at John-Hopkins last year was found to be doctors errors, those doctors also don't deserve medical degrees?

Meanwhile, A lady who has 2 previous children and is rhesus negative gave birth recently, a direct coombs test and blood group was done for the new baby and the child was rhesus negative, I was happy for the child, question is would the woman need rhogam?, bearing the fact that the blood group of the other children are not known?, and they are not present to take their blood group.

Lastly hemoglobinopathies and thalassemias are actually different. and are on different topic. Not all thalasemias are hemoglobinopathies. Do ur research.

sgtponzihater1:
I hope so too. Thalasemias, strictly speaking are not hemoglobinopathies, though some thalassemias can be, since hemoglobinopathies is really alteration in structure, while the other deal with production. There however is no need to query anyone's qualification, if u feel u know better simply explain professionally.

Lagusta:
You are very stupid!!!

Is this a wikipedia source??

Did u even read my post!!!

Oh God how did I end up with this dimwit!!!!

sgtponzihater1:
My guy don't say that. U should go to his school and contend his degree, we can't know it all. Among the top 3 causes of death in a research done at John-Hopkins last year was found to be doctors errors, those doctors also don't deserve medical degrees?

Meanwhile, A lady who has 2 previous children and is rhesus negative gave birth recently, a direct coombs test and blood group was done for the new baby and the child was rhesus negative, I was happy for the child, question is would the woman need rhogam?, bearing the fact that the blood group of the other children are not known?, and they are not present to take their blood group.

Lagusta:
The hemoglobinopathies encompass all genetic diseases of hemoglobin. They fall into two main groups: thalassemia syndromes and structural hemoglobin variants (abnormal hemoglobins). α- and β-thalassemia are the main types of thalassemia; the main structural hemoglobin variants are HbS, HbE and HbC. There are many subtypes and combined types in each group. The highly variable clinical manifestations of the hemoglobinopathies range from mild hypochromic anemia to moderate hematological disease to severe, lifelong, transfusion-dependent anemia with multiorgan involvement. Stem-cell transplantation is the preferred treatment for the severe forms of thalassemia. Supportive, rather than curative, treatment consists of periodic blood transfusions for life, combined with iron chelation. Drugs to treat the symptoms of sickle-cell disease include analgesics, antibiotics, ACE inhibitors and hydroxyurea. Blood transfusions should be given only when strictly indicated. More than 90% of patients currently survive into adulthood. Optimally treated patients have a projected life span of 50 to 60 years.

Source:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3163784/

The guy read wikipedia, when he knows wikipedia is the worst reference any doctor would go to.....

Nigerian doctors..... Na wa ooo

Lagusta:
Someone that doesn't know that thalassemia is a form of hemoglobinopathy does not deserve the medical degree abeg.....

peacettw:
I will assume that you are one of my med students now... Let's go back to basics


What makes up Sickle cell disease and differentiate that from Sickle cell anemia?

How can one inherit these Sickle cell diseases?

In a developing country that lacks the basic tools to detect Sickle cell diseases, what problems are to be expected? Explain this from a medical and social context?

Finally, what can we do to mitigate these errors and how best can we educate the public?

Lagusta:
My oga, I'm sorry but you're mixing it up....

Both are hemoglobinopathies, reason being that the sickle cell genotype is caused by a qualitative defect in which an amino acid replaces another (can't remember) making the red blood cells to form a sickle shape in a hypoxic environment.....

Whereas the thalassemias are caused by a quantitative defect as u rightly said.....

I wish a hematologist was here to clarify this....

Lagusta:
Hahahahahaha, maami you finally schooled him!!!!

Lagusta:
I am a doctor too....

Thalassemias are also hemoglobinopathies, at least that was what I was taught in hematology class....

@topic: yes I read through the last thread, and actually, I don't see the fuss in it....

I have seen many cases of SC and even AC during both medical school and practice itself, but haven't come across the Punjab trait or any of the thalassemias....

Thalassemia is common in the Mediterranean, though may be rarely seen in Africa....

The Punjabi trait is found more in India, though may be rarely found in southern Africa too....

In medical practice, we know the saying "common things occur commonly" quite well, so I don't think we should bother about the Punjab or thalassemia hemoglobinopathies, and if we come across them we promptly refer to a teaching hospital to see the consultant hematologist and his team of residents.....

Ordinary SS some doctor no fit manage, na Punjab genotype we dey open yansh about, na wa oooo

peacettw:
True again, hence the reason I broke it down so that many will understand

peacettw:
True again, hence the reason I broke it down so that many will understand

peacettw:
I am a doctor and if you are too then saying that something is rare doesn't mean it isn't possible. As doctors, we are always taught in medical school and residency that nothing is ever constant. Anything can change and once explained with facts, it becomes the norm until someone else discovers something different and so on.

Unless, you have traced the genealogical histories of every person in Nigeria, then please know dt it is very possible to see even the rarest of genes here.

peacettw:
An op in an earlier thread tried his best to pass across an important message which was misconstrued.
https://www.nairaland.com/3922963/yes-it-not-impossible-aa


I understood his line of thought and tried replying to some who didn't understand him but along the line thought it better to create a new thread.

Below is what the op was trying to explain in layman's terms.

Our people wrongly believe that the only Sickle cell disease out there is SS. In truth, there are many 'combinations' like SC, SB-thal, SD punjab etc. (notice they all have one thing in common, at least one S in the combination)

Now let's put our heads together, how do you think people get these other types? ....
Ans: exactly the same way you get the SS.

So, if you are AS and get married to AC, AB-thal, or Ad punjab, u stand a risk of getting a child with Sickle cell disease. It's that simple.

Another question... How many of our labs here in Nigeria do you think can correctly detect AC, AB-thal, or Ad punjab?
Ans: Basically a few. I saw my first SC in a px 2 years ago in a 17 year old who was told her whole life that she was AS.
Most labs can't pick up the C, b thal or d punjab, once they see an A with no S, they automatically assume it to be AA but in truth might actually be AC, AB-thal, or Ad punjab.

In essence, it is possible for 'AA' (wc we know now might actually be AC, AB-thal, or Ad punjab) to get married to AS and give birth to SC, SB-thal, SD punjab.. (wc again our labs will incorrectly call SS since they lack the proper equip to detect the C, b thal or d punjab and seeing one S and no A will call automatically it SS).

If you are in doubt, then recheck your genotypes in a center with the right equipments.


I hope I have sufficiently cleared the air. Now, please go and spread the word and stop castigating that poor innocent woman.


Cc: seun, mynd44, lalasticlala

givbitcoin:
I'll be glad to inform you that those championing restructuring propaganda are enemies of the state. Like you, most of them are ignorant of what restructuring actually stands for.

The purpose of this propaganda was achieved in 1999 when we freely handed power to South west. But bad songs can be contagious, which is why this very blackmailing approach has refused to die off.


Ebonyi state governor, a wise man, recently opposed restructuring because, according to him, his people would languish should the 2014 confab report be implemented.

There is terrible hunger in Oyo state as we speak, even with the monthly allocation. Now, think of when the allocation is finally deprived.

There are lots of states like these two.

We can't be that wicked to allow citizens of this country starve just because of few selfish individuals.

North is very self sufficient, in terms of food but it's only fair to share with the rest of the nation.

When some stupid animals from Yoruba land started this madness in 1993, they called it sovereign national conference. Now they have crawled back into their shells but the damage has benn done. Some gullible Nigerians are now singing the same song.

Have you seen why Yoruba people must be punished?

givbitcoin:
I'll be glad to inform you that those championing restructuring propaganda are enemies of the state. Like you, most of them are ignorant of what restructuring actually stands for.

The purpose of this propaganda was achieved in 1999 when we freely handed power to South west. But bad songs can be contagious, which is why this very blackmailing approach has refused to die off.


Ebonyi state governor, a wise man, recently opposed restructuring because, according to him, his people would languish should the 2014 confab report be implemented.

There is terrible hunger in Oyo state as we speak, even with the monthly allocation. Now, think of when the allocation is finally deprived.

There are lots of states like these two.

We can't be that wicked to allow citizens of this country starve just because of few selfish individuals.

North is very self sufficient, in terms of food but it's only fair to share with the rest of the nation.

When some stupid animals from Yoruba land started this madness in 1993, they called it sovereign national conference. Now they have crawled back into their shells but the damage has benn done. Some gullible Nigerians are now singing the same song.

Have you seen why Yoruba people must be punished?

givbitcoin:
You owe us all the allegiance. We allowed the freedom you are abusing

givbitcoin:
What if I told you that Nigeria will never be restructured?

What if I told you that the entire South will never go beyond VP again especially Yoruba people.

Yoruba are completely useless to this country