AloneTK:




Nice comment you have there. But I'd say we shouldn't even allow options aside from the first you mentioned.
My wife is a medical doc and I remember the first thing she asked me during our courtship (stylishly though) was my genotype. Na dem dey treat these kids but even many of them ain't willing to take chances.

CONFAMA:


You probably don't understand what I meant. Let's assume they decide to have ten children. What is the probability that at least one of them would be SS compared to just having two kids.

So the fewer the number of children, the lesser the probability that at least one of them will be a sickler.

Haryorbammmy:
In this age when you can easily get the baby tested once the pregnancy is 3 months and you flush it out of the result comes out SS. Chairman, leave your brother alone and go start your family. You all just think it is easy for everyone to just let go of their lives ones. Your brother emotional level might be different from urs. So leave that lover boy alone!

ranmoor:
If your bro is rich or d wife, then there is no prob. They can conceive thru IVF. Using in vitro fertilization, they can fertilise the healthy cells and discard the sickle cells... They just have to make sure baby making is thru ivf..
Anything aside that is a real problem! Even the child will not forgive them.
Peace!

OkoYibo:


Love is not blind in this century. Go and read up on PGD testing. CVS and amniocentesis tests.

DopeAngel:
the thing on my mind right now to do is to warn the girl to seriously stay away from my family and brother or else she wont like the treatment she will be getting from me. i will never ever support the marriage. i am not ready to be an uncle to a sickler. the girl wants to ruin my family. my brother is been perpetually ignorant and foolish. i really dont know what is wrong with him. too much disappointment is not enough reason to go ahead with this marriage. i am tired and unhappy. please i need serious advice on how to end this evil relationship. lalasticlala mynd44 ishilove any other moderator please help a brother in this problem

laudate:



Do you think everyone's pockets are the same? Is it everyone that spends 5 million on a wedding? Don't believe all the hype you read in the society pages of several newspapers or online publications. A lot of people are still getting married for far less amounts, in Nigeria.

Go to the same LUTH you mentioned earlier, and see how patients die like flies due to lack of adequate financial resources to buy medication, and undergo treatment that is critical to their healthcare. I have seen a widow lose her 3 week old baby before, due to lack of funds to buy drugs, inside that same LUTH ward.

Are you the one going to stabilise the OP's brother financially? What if he gets married and they are not financially stable enough to do PGD, CVS and IVF? Even IVF has its own failure rate too, depending on age and other factors! I know women who did IVF 5 times, and yet - no pregnancy.

Angelawhite:


Would you be happy with your parents if you were born a sickler? This is not about the parents here, it's about the child. I lost my best friend at the age of 18 to sickle cell anemia. The pain was just too much for him. He'd wake up in the night screaming and yelling and begging to die.
Would you like your nephew to suffer this just because the couple are adults and it's no business of yours.

Something that should be openly criticised in this age of modernity is being encouraged because you serve a living God.
Jump in a lake of fire and watch your living God save you.
Marry an AS with your AS genotype and watch the living God deliver you

Tony142:
My parents make this BIG mistake, and since my childhood me and my siblings have been suferring for what we did not know about



Pls advice him not to do it, cos he will regret it soon, and it will not b funny




**talking from experience**

oceandivee:
Just take your brother to any hematological centre in any close by tertiary health institution, so that he could see for himself children suffering from sickle cell disease. If he is ready to go that way for life, then leave him to his fate and count yourself out. Goodluck

eyinjuege:


What's my business if you decide to worship Satan?
Please get off my mention. I wonder what's bringing religion into this.
You're talking of age of modernity? Nonsense. You're still behind in the 19th century.
At this age of modernity, why should genotype be a prerequisite to marriage?
You lost your best friend to sickle cell disease? Boo hoo, cry me a river. I lost a good friend to cancer of the breast. Does it mean that since a lot of cancers are inherited genetically, people with a history of cancers in their families shouldn't marry each other?
Please learn to see things outside your closeted mind. Because
Your child will not be happy with you if born a sickler? Yen,yen. The child would be happier if never born then.
As though we dont have sicklers in the world doing alright, and bringing joys to their families. Young people also die even without being sicklers, so is death supposed to be a scare tactic?
Should genetic disorders that can be inherited be a prohibition to marriage? So many diseases have some genetic component to them, even things as common as diabetes, cancers. So people with such family history in their parents shouldnt marry each other?
When the wedding day of this couple arrives, you and the OP can carry thugs to disrupt it

Angelawhite:


I find your argument riddled with a lot of fallacies.
Smoke igbo because others did
Produce a sickler because diabetes check is not a prerequisite for marriage
Produce a sickler because young people die of various ailment
Pass this advice to your children and children's children because cancer killed your friend

Cindino20:
I m forced to drop my comment after reading this..it is not my place to tell an adult what to do...to each is own....

my brother have you thought about what you re about to get into and the implications of the advise you re dishing out. thinj about some of the points below.

to advise people or to get married when you both are carriers in a country like Nigeria with the very bad state of the health care and bad shape of the economy is actually not a wise decision.

Even if the would be couple were to reside in a country with free and more advanced health care system i wont advise them to go on.

Do you ve an health insurance plan that covers these treatments? Do you even have an health insurance plan at all? if no will any health insurance take you on with such issues..i doubt cos they aint no fools and are set up to make money ..to them you re just a bad client that will be avoided cos your future family will viewed as a client with "pre existing condition"

Today you re okay and can afford sampling and IVf...the economy is not risk proof and things can turn in a split second and really go sour especially in Nigeria's case where the economy is highly dependent on oil.

if things go south and your economic condition changes, will you be able to afford these treatments? is it not better to avoid them than set up your life to be dependent on such things?

I keep hearing sampling the Foetus baby and then do an abortion if the result is not favourable.

why in 2018 would any sane person gamble with things they can easily control..The science is there ..preventive medicine is cheaper. why put yourselves through this?

I am liberal as it gets but i dont see why someone will set up his life to regularly sample and do an abortion. Abortion should be done when needed and it is not something you should plan to do regularly. the effect of abortion on your would be wife you still dont know...if you were to be the one (the lady) would you regularly subject yourself to such...if the abortion was to be conducted regularly on you will you still go on with this plan?

are you also aware that before an abortion..you need counselling because of the emotional implications? have you thought about the effect of the emotional implication of the abortions on your relationship?

IVF cost abt 10-15K usd. if you go down this route do you ve the money stashed up already and can you afford this for the number of kids you want.

Unless you re an otedola with the Money..this sounds like a no brainer to me man.

Adopting seems to be an option..can you deal with that?

love is beautiful....dont mess it up..if you really love that girl and you love yourself ..you will take a walk...you dont always get the things you love...sometimes you ve to let go.


In all...I wish you the very best going forward!


I m starting to think that those pushing the IVF and sampling technicques re people who ve made such mistakes but dont wanna own up to it or medical professionals who stand to benefit from it....smh!


@Dopeangel....Talk to your bro once again and if he insists so be it..you cant do much and dont involve outsiders just close friends and immmedialte family.

btw you keep hammering on the effect it will have on your family..if after the warning, your bro decides to continue cos he wants to solve a temporal problem with a permanent one...then it should be his problem and not that of your family..it sounds harsh but yes you ve your own life and the mistakes of others in this case one that can be avoided should not have negative effect on your fams happiness...If he is man enough to neglect the science and pull a movie script on you guys then be man enough to also allow him face the consequences of his actions..you cant eat your cake and have it.

you ve done well as a brother..maybe a bit too pushy cos you want the best for him.

Fhowe:
Nigerians just like to discourage one another it is even 150k we are no longer in the 80s and with competition it will still come down .

tunjilana:
Firstly there are two options for them and they both require courage and a lot of money

No 1. IVF (which can fail and is crazily expensive. genetic diagnosis + IVF could gulp close to 5-6 million for 2 cycles)---I advise they visit a fertility clinic and confirm the cost first

No 2. Prenatal diagnosis - Test the pregnancy at 10-12 weeks and abort if SS. This is emotionally draining and considering you are not clear on the number of abortions you will end up doing

In summary, this decision is not for the faint hearted or lazy. If your brother embarks on this option and funds become a major issue coupled with a wife who isn't financially ready as well, meeehn that love go evaporate o

I advise he goes about to understand the cost(financial and emotionally) of avoiding a sickle cell birth and if it is something they can deal then goodluck else simply find a woman you are compatible with.

Regards

Regards

Tellemall:
What if that SS child is the first or second child?

Looking at it mathematically, that particular 0.25 will occur randomly unless they have full control of other dependent variables such as their gene transmission, which we know they don't.

That is a rather high risk to take. Lives shouldn't be gambled on.

pandax:
I reside in PH and not abroad. In fact the cost of PGS & IVF has gone down now. There are clinics like Nordica, Bridge and the rest in Nigeria that can comfortably carry out the procedure with their foreign partners. it is doable. I married my wife with my last N1m in my account and I knew that we were not compatible because of our genotype. I love her and was able to do it because we did not tell anyone except my mother-in-law who supported us. Till today, we have not done white wedding as most churches refused wedding us. I told my wife to follow me that God will see us through. Today, I have tens of millions within 2 years of marriage and my healthy triplets are on the way. Maybe, after delivery we will go back and see if churches will wed us.

eyinjuege:


You're still not making any sense.
Its non of your business if I have a child with sickle cell disease. Non of your business at all, and you should learn to keep your nose where it belongs.
If you decide not to marry someone based on their genotype, nobody gives a flying hoot. Its your choice. Same way you should stay on your lane and not carry other people's matter on your head.

Meanwhile, it will be interesting to know the fallacies you claim to have found in my statement, just to enlighten anyone reading it

hayzed1090:
Pls o house, am AS and my fiancee is AC. Are we good to go?

ranmoor:


Partner X Partner Y Partner X partner Y

AA AA Can Marry AS AS Not to Marry

AA AS Can Marry AS SS Not to Marry

SS AA Can Marry SS SS Not to Marry

AA SC Can Marry AS SC Not to Marry

AA AC Can Marry SC SC Not to Marry

AA CC Can Marry AS AC Not to Marry

AC AC Can Marry AC SC Not to Marry

Three major groups of genotype are: AA (Normal); AS (Carrier), SS (Sickler). Others include SC AND CC.

red bldThe blood is made of various cells suspended in plasma. The red blood cells are our major focus here since they contain within them hemoglobin, a substance which helps in the transport of oxygen to the tissues.

This hemoglobin is composed of 2 parts: a heme and globin (2 pairs of protein chains).

There are 2 alpha and 2 beta globin chains – the pair, and there is a way in which the chains ought to be arranged.

An error occurs when a protein substitution occurs in any one of these chains – but particularly in the globin chains (amino acids are the building blocks of proteins which make up the globin chains – so if amino acid ‘x’ is the normal, an abnormality occurs when instead of ‘x’ at a particular location along the chain, you have ‘y’.)

For:

Genotype AA: At position 6 of both globin chains, the amino acid is GLUTAMATE

Genotype AS: At position 6 of one globin chain is GLUTAMATE and at position 6 of the second globin chain, you have VALINE

Genotype SS: At position 6 of both globin chains, the amino acid is VALINE

Genotype AC: At position 6 of one globin chain is GLUTAMATE and at position 6 of the second globin chain, you have LYSINE

ABNORMAL

Hemoglobinopathy is a genetic disorder caused by abnormal polypeptide chains of hemoglobin.

Some of the hemoglobinopathies are:

Hemoglobin S: It is found in sickle cell anemia. In this, the alpha chains are normal and beta chains are abnormal. The sickle-cell disease occurs when the sixth amino acid, glutamate, is replaced by valine to change its structure and function. Valine is hydrophobic, causing the hemoglobin to collapse on itself occasionally. When enough hemoglobin collapses on itself the red blood cells become sickle-shaped.230px-Sickle_cell_01
Hemoglobin C: is an abnormal hemoglobin in which substitution of a glutamic acid residue with a lysine residue at the 6th position of the β-globin chain has occurred. It reduces the normal plasticity of host erythrocytes causing a hemoglobinopathy.
In those who are heterozygous for the mutation, about 28–44% of total hemoglobin (Hb) is HbC, and no anemia develops. In homozygotes (i.e. CC), nearly all Hb is in the HbC form, resulting in mild hemolytic anemia.

People with hemoglobin C (carriers) do not have Hemoglobin C disease or sickle cell disease and cannot develop these diseases later in life.

They can pass the trait to their offspring: Individuals who carry the hemoglobin C trait can have a child with Hemoglobin C disease or Hemoglobin SC disease. Hemoglobin C disease IS NOT a form of sickle cell disease. It is present at birth, though some cases may not be diagnosed until adulthood. People with hemoglobin C disease can expect to lead a normal life.

page1-800px-Aminoacid_chain_normal_Hb_and_HbE.pdfAmino acid chain normal Hb-Top row and HbE- Bottom row

Hemoglobin S-C disease is a hemoglobinopathy (see Hemoglobinopathies) that causes symptoms similar to those of sickle cell disease, but milder.
Because 10% of blacks carry the Hb S trait, the heterozygous S-C combination is more common than homozygous Hb C disease. The anemia in Hb S-C disease is milder than the anemia in sickle cell disease; some patients even have normal Hb levels. Most symptoms are those of sickle cell disease, but symptoms are usually less frequent and less severe. However, gross hematuria, retinal hemorrhages, and aseptic necrosis of the femoral head are common.

Hb S-C disease is suspected in patients whose clinical features suggest sickle cell disease or whose RBCs demonstrate sickling. Stained blood smears show target cells and a rare sickle cell. Sickling is identified in a sickling preparation, and Hb electrophoresis establishes the diagnosis. Treatment can be similar to that of sickle cell disease but is determined by severity of symptoms.hemoglobin

Hemoglobin AC: Hemoglobin C trait results when the gene for hemoglobin C is inherited from one parent and the gene for hemoglobin A from the other. This carrier state does not usually result in health problems, although there may be a slightly low MCV and target cells.
Hemoglobin E: Here also the beta chains are abnormal. It is present in people with hemoglobin E disease which is also characterized by mild hemolytic anemia and splenomegaly.
Hemoglobin M: It is the abnormal hemoglobin present in the form of methemoglobin. It occurs due to mutation of genes of both in alpha and beta chains resulting in abnormal replacement of amino acids. It is present in babies affected by hemoglobin M disease or blue baby syndrome. It is an inherited disease characterized by methemoglobinemia.

1Sharon:


So much ignorance and naivety in this post . You really need to update ur knowledge cos sickle cell is not how it used to be and is not what you assume it is.

Ignoramus

misreal:
Your hatred for the girl will not change anything sir..you either believe with your brother that God can do anything,or forever remain silent..

DopeAngel:
thank you fear. the thing is the girl herself is not ready to let him go. she still even calls him. her age factor is making her even more desperate. i dont care if the girl gets married or not. she should just leave my bro alone. i mean is that too hard for a lady to do? am so much pained. right now i have so much hatred towards the girl. right now i am thinking of giving her a very sound warning to stay away from my family or else she would never find peace. i would be very happy to be the black sheep that destroyed the relationship and save the lives of my bro's unborn kids. is it right?

eyinjuege:
Its not your relationship, neither is it your business.
The main thing is for both of them to understand the risks involved, and if they're ready to plunge in, goodluck to them.
Your place as a brother is to support. Not dictate, not rule or instruct your brother.
You should learn to respect your brother's choice and wishes. If you're not ready to support him, you can disown him.