₦airaland Forum

Host Genetics and Human Adaptation to Lassa Hemorrhagic Fever in West Africa. S. Tabrizi1,2,3,10, R. Tariyal1,2,10, I. Shlyakhter1,2, S. F. Schaffner2, S. K. Gire1,2, M. S. Stremlau1,2, E. K. Karlsson1,2, K. G. Andersen1,2, E. Phelan2, L. M. Moses4, W. Omoniwa5, I. Odia5, P. E. Ehiane5, O. Folarin5,6, A. Tareila1,2, L. M. Branco4, J. S. Schieffelin4, D. Levy4,7, S. Gunther8, D. S. Grant7, G. O. Akpede5, D. A. Asogun5, P. O. Okokhere5, R. F. Garry4,11, C. T. Happi5,6,11, P. C. Sabeti1,2,9,11, Viral Hemorrhagic Fever Consortium 1) FAS Center for Systems Biology, Department of OEB, Harvard University, Cambridge, MA; 2) Broad Institute, Cambridge, MA; 3) Harvard Medical School, Boston, MA; 4) Department of Microbiology and Immunology, Tulane University, New Orleans, LA; 5) Institute of Lassa Fever Research and Control, Irrua Specialist Teaching Hospital, Edo State, Nigeria; 6) Department of Biological Sciences, College of Natural Sciences, Redeemer's University, Redemption City, Ogun State, Nigeria; 7) Lassa Fever Laboratory, Kenema Government Hospital, Kenema, Sierra Leone; Lassa Fever Laboratory, Kenema Government Hospital, Kenema, Sierra Leone Department of Virology, Bernhard-Nocht-Institute for Tropical Medicine, Hamburg, Germany; 9) Department of Immunology and Infectious Disease, Harvard School of Public Health, Boston, MA; 10) These authors contributed equally to this work; 11) These authors jointly supervised this work.

Lassa virus has the unique status of being both one of the world’s deadliest pathogens, designated bio-safety level 4 (BL-4), and a public health crisis, endemic in large parts of West Africa. It is estimated to have originated over 1000 years ago in Nigeria, and a genome-wide survey of human variation identified the gene LARGE, biologically linked to Lassa virus infection, as among the strongest signals of natural selection in the Yoruba population of Nigeria. We pursued the hypothesis that Lassa virus is an ancient selective force, driving the rise of genetic resistance, by conducting a genome-wide association study (GWAS) of Lassa fever cases and controls in Nigeria and Sierra Leone. We report a signal of association at LARGE, and show that it overlaps with the previously reported signal of selection. This suggests recent evolution of resistance to Lassa fever in West Africa, making it one of only a handful of known loci under positive selection elucidated to be involved in resistance to infectious disease. Population genetics analysis provides further insights into the origins and spread of the resistance variant in LARGE. We show that the same putatively protective haplotype under selection in the Yoruba is also present in the Esan population of Nigeria and the Mende population of Sierra Leone. We find that the frequency is highest in the Yoruba (30%), lower in the Esan (21%) and the Mende (10%), and absent in East African and non-African populations (where Lassa fever is also absent). This is consistent with results from our sequencing of the Lassa genome showing that the virus is oldest in Nigeria and appeared only recently in Sierra Leone, and helps to explain higher fatality rates and greater disease severity in Sierra Leone. Beyond LARGE, our other top GWAS signals fall at genes involved in the immune system, including PTPRE, which modulates expression of cytokines involved in host response to viral infection, and IFRD1, involved in the activation of neutrophils in innate immune response. We also examine signals of adaptation in the Esan and Mende populations and discover numerous novel candidate loci under positive selection, providing new insights into human diversity in West Africa. This work is one of only a few surveys of genetic diversity in West Africa, a region underrepresented in GWA studies. It is also the first ever GWAS on a BL-4 agent, and demonstrates a novel genomics approach to understanding the world’s deadliest pathogens.

You may contact the first author (during and after the meeting) at tabrizi@post.harvard.edu

http://www.ashg.org/2013meeting/abstracts/fulltext/f130122559.htm

@scholes0

I just found another scholarship from Harvard that'd cite Yoruba, Esan, and Mende.

I'll post it now - I hope the spambot doesn't ban me.

cc: lalasticlala ...unban me if the spambot bans my next post.

scholes0:
.

Err, the hypothesis looks more plausible to me now. I just found an academic scholarship by Harvard University and it did corroborate the argument by this hypothesis about LARGE and IL21 genes being resistant to the Lassa Virus. However, it never mentioned Yorubas or any other group.

This is the scholarship: https://dash.harvard.edu/bitstream/handle/1/11248782/3267117.pdf?sequence=1

scholes0:
Other research do exist on the subject matter.
Just search online.

Interesting. I'll check it out.

If I can find any academic scholarship from internationally recognised bodies to corroborate the hypothesis, I'll post it on the other side.

scholes0:
The same Haplotype responsible for the protection of The Yoruba against the Lassa Fever Virus, were also found among the Esan and other Populations of Edo state, but at lower frequencies.

Err, if it's based on haplotype - then Fulanis should also be immune to the virus. Yorubas and Fulanis have a lot in common based on haplotype.

Anyway, it's very plausible. Most Nigerians don't even know that the genetic make-up of all the groups in the country aren't the same and the occurrence of certain haplotype in the different groups varies. Yorubas for example have more in common genetically with the Bamilekes of Cameroon, Tutsis of Rwanda, Mandinka all over West Africa, Fante/Ga/Ewe folks of Ghana etc. than 99% of all the other ethnic groups in Nigeria. While Igbos for example genetically have more in common with a lot of groups in East/Central Africa than Nigeria. Ditto Hausas and the Sahel region of Africa. Etc. Just cos folks have the same phenotype, that doesn't mean that they're genetically the same, though they're all from a larger tree that branched out into different things.

There are certain people, especially in East Africa, that are naturally immune to HIV.

Regardless, since it's a Nigerian professor (not dissing the guy) who discovered this - I don't think I'll take it seriously. But there's nothing bad in doing further research on the hypothesis.

Loool.

The Ooni is visiting everyone based on the true hierarchy, but the Alake just had to use the opportunity to start another disunity.

Why put Oba of Benin there? And who made Egba number 4 on the list?

Ooni knows what time it's, hence he visited the big two first.

NOETHNICITY:
I get ur point! I like Buahri as a person but am not a gullibly bigoted fan of his! I denounced him when he erred about d 97% and 5% vote issue! However, we must knw that he is not a perfect being! And I do feel that he does deserves time! About the other issues u raised, am 100% sure that considering d current financial mess we re in, Nigeria is not going to make any monetary contribution to that coalition. 2nd am also 100%sure we re not sending our troops out to that dangerous and perilous battle ground! But we might cooperate with them in d area of sharing intelligence! Thanks!

Keep doing you and don't let bigotry and detrimental partisanship that has turned a lot of these nauseating illiterates into useful idiots get in ya way of being objective. No one is infallible and Buhari has shown over and over again thus far that he lacks the cerebral capacity to govern a country like naij. And folks need to start telling the truth cos the country needs results - not medieval personality worship that's synonymous with feudalism.

A lot of these clowns don't even understand race relations in the UK in context on Nigerians. Nigerians are the new Jamaicans in the UK and I'm sure some of you have seen videos of a few white folks accusing just any random black person of being Nigerians. And in London, Nigerians get targeted from time to time. So if Buhari had proper handlers, they would have told him to watch his mouth.

NOETHNICITY:
Bros,on many occasions I admire ur views on issue but I beg to differ on this! I ve been lamenting for ages about the natural propensity for an average Nija to be criminally minded sometimes! Do u knw the terrible unspeakable and unbelievable crimes our brothers comit in foreign countries! Nigerians single-handedly destroyed the integrity of d black race in Libya. It was sooooo bad that Libyans started to spit on any black person seen on the streets.Nigerians are soooooo unimaginably terrible that even other Nigerians run away when they see their fellow Nigerians in foreign countries! Nigerians are jus too bad! And what is bad is simply bad! As a matter of urgency we need to own-up and get honest wit the trut that our pple, home and abroad, need a change of attitude! Imagine what these two Nigerian did to their generous chinese employers in Benin City in this post; www.nairaland.com/2917841/employees-set-fire-house-chinese! this is a very small crime when compared to others!

@ bold - I'm not disputing. Actually, I was probably the first person to posit on this forum that the average Nigerian is criminal minded and he/she thrives on cutting corners. I'd get a lot of flack for that.

However, in this context, you just can't say that openly as the leader of a country. With what he said, he has given the UK the lee-way to start treating Nigerians a certain way and no one would be able to question that cos the president of Nigeria created the avenue for it with his loose talks. That's basically the point I'm trying to make.

Let me digress a bit: how come no one has a problem with all the misguided soundbites from everything Buhari said yesterday, from this one, to what he said about his personal doctors being in the UK, to his claims that there's no evidence to prosecute Diezani despite all the noise from his government and Sanusi, to his excuse about being the president at the wrong time? Isn't his honeymoon over? Why are folks giving him a pass, despite his lack of achievements since he took over?

Then when you look at his travels and the foreign policy of his government - you would see how much of a failure he has been thus far. He travelled to Iran, came back, and decided to get entangled with the shiites, thus making his travel to Iran a wasteful thing. Then decided to join an unnecessary coalition with Saudi Arabia and Qatar to fight an ISIS both countries created and funded. The Syrian war is about to take a new twist after the combined forces of Russia, Syria, Iran, Shiites, and Hezbollah encircled Aleppo a few days ago and there might be a showdown between those on the Russian bloc vs. those on the US/Saudi/Turkey bloc. So since Nigeria is in coalition with the latter - is he also going to send Nigerian troops there at the mercy of Russian bombs and their special forces? Why's Nigeria involved in something that has absolutely nothing to do with Nigeria?

babafirst:
Please,Prof Gates case is not a perfect example to cite here,it involved racism (tribalism if it happened in Nigeria) and Obama had to be cautious(and all Nigerians are cautious too when it comes to tribalism and in 'real life' they pretend to love each other but on Nairaland where they are 'faceless' they show their true colours) but PMB mentioned a problem that involves all tribes not representing Nigeria well abroad and not the hardworking ones like Odion Ighalo,Emenike,Obafemi Martin's or my elder brother who is a 'first class' medical doctor in the UK today. Ofcourse that comment has not reduced my brother's clients/patients one bit.

I'd say I was citing the Prof. Gates saga out of context and I only cited it to buttress my point that being "blunt and cold" when dealing with certain issues isn't how you show leadership.

Do you live in the UK?

If you do, I'd like to use MP David Lammy's case during the London Riots as an example. David Lammy threw Tottenham, his constituent, under the bus during the riots. There was a lot of backlash cos he's black, from Tottenham, and he represents Tottenham in the house of commons. The only folks who supported him were racist white people. Heck, even some went as far as saying David Lammy is the type of black person white people like - a house nyggah.

abbey621:
Broda my experience in Nigeria has taken me to heights here in the U.S, heights that many can only dream of, I don't know where you live and frankly I could care less, if you deny the Nigerian in you then you are even more delusional than it seems. In response to your question, the only backlash Obama got was from the opposition and a few others who held little opinion of him anyways! Majority of democrats and people of ethnic backgrounds supported him. How about you look at this scenario, Obama after the shooting death of Trayvon Martin making a statement that he fears the mere thought of his daughters or one of their friends walking by in a neighborhood and being harassed by a cop just because of their skin color or the type of garments they wore. The president's statement clearly stirred up issue of racial profiling and race generally in America, he was attacked by the opposition but majority of people clearly understood what he was saying. My point is this, a president does not have to be politically correct all the time, the greatest presidents in the history of the world have always been surrounded by controversies and it takes guts to be able to say what you mean and mean what you say!

Good for you. However, that doesn't everything wrong with the mentality and it's a mentality that's very difficult to shake off. Err, you're the delusional one for trying to all get defensive about ya experience. My experience is different and regardless of what anyone feels about it, I align with my experience all the time. I'm a realist - I don't run from who I'm and everything that shaped my existence.

Anyway, why didn't naij give you the opportunities the US gave you? And shouldn't Buhari be doing the same in naij by giving those in naij the same opportunities to get to whatever height they want to get to, rather than spouting tripe everywhere?

With Obama, it wasn't only the opposition - there was a backlash all over the US. Why do you think he apologised and organised a beer summit to defuse everything? You think complaints from only the opposition would've made him do that?

He was diplomatic in what he said about Trayvon Martin, especially with the way he used his daughters to tell the narrative. That's how a president should talk - not Buhari's way of opening his mouth before thinking.

abbey621:
How wrong could one person be? I'm just laughing at you cos your assumptions are making the little credibility your argument might have dwindle. Since you don't know me or know what I do for a living, I forgive you for your first blunder but the other blunders in your write-up is inexcusable! It's a pity you and others have decided to turn the president's statements into something else but it doesn't change the fact that Nigerians living abroad have nobody to blame but themselves! If they are not contented living in another man's land then let them come back home and rebuild, the ones living in Nigeria are not animals and they do not have two heads. As bad as it can be sometimes living in the U.S.,I still appreciate the good opportunities provided and always thankful for my achievements so far. Not everyone is meant to be successful abroad and you can't expect Buhari to support nagging and whining from frustrated souls abroad most of whom are victims of the evil committed by their fellow Nigerians abroad. You also mentioned if Nigeria was better most people wouldn't migrate but tell me this, is Nigeria the only country where suffering exists? The president has not done or said anything damaging, the only damage exists in your mind and the mind of those who can't handle honesty!

Okay, you live in America. However, that doesn't negate the fact that you can take a naij person out of naij, but can't take the residual effects of naij experience and the mentality out of the person. And it's very evident in ya posts.

In as much as the US isn't a shinning example to define refinement cos the average yank is a brawn. I'd like to cite a similar example from America of the president of a country being supposedly "blunt and cold" unnecessarily in a different context and I'll like to know what you think. During the Harvard Professor, Henry Gates, and the police saga of racial profiling and forceful arrest in his home. I'm sure you remember Obama, as the POTUS, was "blunt and cold" when he gave his opinion on the issue. But what backlash did he get for being unpresidential in his approach, despite the fact that everything he said was right on the money? Once you can answer this, you'll understand why Buhari's wrong.

abbey621:
Once again you still don't get it. Buhari is not a cosmetic president, everything about him is shockingly blunt! If you are going to leave the context out and just focus on what he said then it's never going to make sense. You claimed the president is lumping all those abroad with criminals, this is a flat out lie! He only mentioned that it would be hard for Nigerians to be treated fairly when our reputation crashed from the actions of Nigerians abroad committing criminal acts. I've been working abroad for quite some time now and I deal on a daily basis with different types of people and trust me Nigerians are more famous for 419 scams than education or innovation. The president just gave them an option,if they can't deal with poor treatment abroad then they should come back home and develop their country. I'm sorry you feel like the president is a dud, I completely disagree with you on that! I believe the right choice was made by Nigerians and I would rather have a Buhari that seems cold and blunt on the international scene than a government where stealing is not corruption!

You sound like you live in naij. So I kind of understand ya mentality and angle. And I believe a lot of you are still dealing with the residual effects of living under the military rule for a long time, or perhaps it's cos of the chaos in naij and how aggressive most naij folks are (that's evident in the aggressive way most naij folks talk). However, the international scene is a different kettle of fish entirely, especially when you're in a position whereby you've to be diplomatic in ya approach to things and whatever you say represents the image of the country.

Even as erratic and eccentric as Muamar Gaddafi was - apart from always talking too much - he was never like this when discussing issues about his own people or black folks in general. Are a lot of naij folks out there unrepentant criminals soiling the name of the country? - absolutely yes. But there's a place and time to discuss certain issues. You can just open ya mouth as the president and start chatting shyte everywhere. Common courtesy should tell you that certain topics are best addressed behind closed doors or in private.

Okay, let's say all Nigerians abroad are criminals and he believes they all need to come back home. After blowing unnecessary hot air, thus disgracing himself and Nigeria in the process - has he got anything to offer them in Nigeria? If naij weren't a messed up country, would the criminals be eloping from naij in droves to survive in other countries? And how are criminals going to even go back "home", where nothing works, to build anything, other than continue their supposed criminal activities to survive?

Being stupidly blunt/cold won't fix anything. He has been there for months now, what has he achieved? He can't even create a decent budget. Then he has been running around giving excuses about being the president at the wrong time. And also the tripe he said today about the non-existence of evidence to prosecute Diezani. The man looks like a clown...he's GEJ 2.0. Nigeria is definitely cursed with bad leaders.

CSTR2:
Where is shymm3x? It is your people that have populated UK that buhari is referring to.
Yoruba criminals have taken over the united kingdom.
*dodges bottle*

Shut ya gob.

The old man is senile. I guess he thought he was in Malaysia or Jakarta cos naij folks aren't known for drug trafficking here. If he had alluded to scam now - then that's about 80% of naija hustle in the UK.

And we all know those who populate the dungeons of Malaysia and Jakarta.

abbey621:
I respectfully disagree! Nigeria is not the United States of America or the United Kingdom, we are still a developing country and need to stop pretending otherwise. The economy is in shambles and almost every sector is in decline, this is mostly due to corruption and partly due to our best human resources leaving the country for greener pastures. The president was responding to a specific question and gave the right answer! This is not the time to be mixing words trying to be politically correct. If live is hard abroad come back home and develop your fatherland, the answer is blunt but it is absolutely right!

And the best way to lure professionals back "home" is by lumping them with the criminals in the international media, no? What type of decent person would listen to that and feel the need to go back "home"? Unless he wants the criminals to return home to contribute more criminal activities to the utter destruction that naij is perpetually in.

What's at "home" for folks to go back to, anyway? Didn't he also complain about "home" when he said he became the president at the wrong time with all kinds of stories that touch the heart, at the same function? Yet he wants folks to return to that mess, especially when he can't even create a decent budget and he has been a dud since he took over, while blaming everyone but himself - rather than focus on doing what he was elected to do. He needs to watch his mouth and learn how to talk.

I saw a bit of his interview today with some naija guy working for BBC. And he was just passive aggressively speaking with a commanding tone. That's not a presidential way to speak to the media. He needs to work on that.

abbey621:
Can someone show me exactly where the president called all Nigerians criminals? Are we so filled up with sentiments in this country that we can't separate the truth from plain manipulation! What the president was trying to say is simple. Nigerians should stop seeking asylum abroad because such privileges have been abused by their countrymen in the past due to drug trafficking and other criminal acts. Is this far from the truth? Especially in UK, Nigerians are increasingly filling up the prison system, I dare anybody to bring up facts that are contrarian! Perhaps we feel it's better to be politically correct than being honest but we all know with PMB he speaks from the heart.

It's not about the truth. It's about the context of his office as the president of Nigeria and being the face of the country, especially when speaking to the international media. I'm sure you know whatever he said represents who he's and his office cos he represents the people.

You can't be blunt about everything as the country's first citizen, hence leaders always have handlers and they have to speak a certain way. Buhari needs to stop talking to the international media till his handlers can teach him how to talk the right way.

Lol.

BooHarry's handlers need to teach him how to speak the English language in a presidential way.

When it comes to English language usage - BooHarry and Idi Amin are cut from the same cloth.

CSTR2:
I consider myself very progressive, forwardminded and hardly judgemental, but nothing would make me marry a lady who have confessed to sleeping with 43 men before meeting me.
Even most randy men don't get up to that number before 40, let alone a woman who is supposed to be the mother of my kids and a role model to people around her.
I 'd run without looking back. I value my reputation and sanity.

Lmao @ very progressive minded with chics. That's the easiest way to a half-way house somewhere in Alaska. Even Sarah Palin won't be able to save ya arse, despite the fact that she can see Russia from her backyard.

Once a woman has an extremely high number of guys who have pee-ed in her bottomless pit, trust me, there'll always be at least 2 or 3 with permanent da vinci code to unlock that pum whenever they feel like. That means once you're not around, a next man is going to be in ya house beating the brakes off the back of ya "wife" to smithereens. And old habits don't die - you can suppress them a bit, but anything can bring them to the fore again. Don't ever make a who.re a housewife.

How are you even going to sleep with ya two eyes closed next to a woman with that crazy number without going berserk? I don't even care about how pretentious/secretive a chic is, when I see a sket, I always know. And cos most chics aren't that smart and they mostly fvck around where they live, Unis they attended, or workplace - a little background check is always nice when you meet chics. Don't be a victim like the US was under Dubya.

Off topic:

Getting ready for my white nyggah, Bernie Sanders, to become the next POTUS, no? [size=4pt](Jeb Bush - erm, I know it's Jeb Bush's election to lose cos no one has the structure to stop the Bush dynasty)[/size]

dacovajnr:
Just don't tell me you still call your Pusay private..coz it has become public liability company

Lmao...that's creativity and wittiness. Salute!

That's the type of public toilet any guy can just take out his big willy and pee in. Some ashtray pum. What type of sane guy wants that? As a guy it's always better to go young (anything between 20-23) for decent chics when you're ready, regardless of how old you're. Leave the banger pums alone - they're only good for quickies.

Once you see the pum with the puzzy mouth looking saggy and puzzy wall looking shaky as fvck - you'll just go:

https://media.tumblr.com/64a1dd4594e3c0eb92928599d7dd070b/tumblr_inline_mo09awJ4Cn1qz4rgp.gif

Lmao.

But why did she lie to him at first? These chics just love get fvcked everywhere and by everyone for no reason - with cum all over their pums and faces. Once the total number of guys you've slept with gets to double digits, you might as well turn it into a hustle and start getting paid for it.

43 guys = banger vagina. That's the type of pum you'll get married to and that will keep breaking down almost every time cos it has 43 different previous owners and an extremely high mileage, based on how the female anatomy is. Men have the luxury due to body anatomy and society standards - not women. Who wants to marry a woman that someone that probably knows someone has fvcked. Even his pops and uncles already ran through that. Some effed up pum right there that ought to be left in the scrap yard and crushed.

I'd rather marry a stripper than go near a lot of these chics running around today. At least with strippers, folks just see but they don't touch.

lordkay10:
Bros u make sense die! It's a pity most Nigerians don't know what it is to be regarded a genius in any field of endeavour, I knew you know so much about real music the moment I saw your comment about Fela, that's the greatest all-round musical artist Africa has ever produced. Thumbs-up

Lol. I do try. I just had to correct these folks cos it seems they don't understand music. You know a beat is great when you can rock to it without anyone singing.

Calling Don Jazzy the greatest producer is like saying P.Diddy is the greatest hip-hop producer ever when every hip-hop head knows that P.Diddy is not even top-20. When you have Rick Rubin, Dr Dre, Pete Rock, J. Dilla, Alchemist, Erik Sermon, Large Professor, DJ Premier, RZA, Q-tip et al. Even Kanye West and Havoc of Mobb Deep are light years ahead of P.Diddy. Yes, P.Diddy produced a lot of hit records - but that had more to do with the talents that graced those beats and his antics than his production skills.

Lol.

It seems folks have bastardised the word "genius". I honestly don't know how a guy who makes basic/generic beats with no layers can be termed the "greatest Nigerian producer". If he's actually the greatest - then the Nigerian music industry is dead meat and it has a long way to go.

I'd even say Davido makes better beats than the guy since he produces his own tunes. And whoever made 9ice's "gongo aso" and Dagrin's "pon pon pon" are far ahead of the guy in terms of production cos those are like most decent beats I've heard in naija music.

Then you had the magic of Fela Kuti. Though it was live band - but no one dead, alive, and/or unborn is touching what Fela Kuti created. That's genius right there, hence he's the most sampled artist ever out of Africa.

Don fatty needs to take several seats.

Rossikk:
Can't think of many westerners who committed grave crimes in China of late, but there's no shortage of them in the case of Africa.

Fair enough.

But is Africa even united to try anyone? And where's the power?

You've got a continent that's still carved up into servitude by different Western countries. Francophone Africa is still under France. Anglophone Africa is still under both the US and UK. North Africa is basically under the Arabs, save for Algeria. Then you've got the likes of Ethiopia, Rwanda et al under the US. Etc.

So how is that even going to work?

Rossikk:
If we had just 10 African leaders with the mentality of Mugabe, Africa will be more developed than Japan in under a decade.

In as much as I'm a big fan of Mugabe and I believe he's the last of an extinct breed of real African warriors - I think folks need to stop talking for the sake of it. Africa has no power to try anyone and there's absolutely no point playing to the gallery and ruffle feathers in the process. Yes, I agree that African countries need to pull out of ICC cos it's basically a tool by the West to keep fostering regime change everywhere. But just leave it there and focus on African unity. I'm sure he saw what happened to Gaddaffi - and the only reason why they haven't touched him is cos of South Africa and China.

China also has its own version of ICC and despite how powerful China is - how many folks have they tried from the West?

Aareonakakanfo:
Baba what's happening here. I wanted to reply you with another one but you prolly won't know it's me

I'm still waiting for you @ the other side.Nothing was done maliciously maan

Leave these animals alone

Lol. What's good, brother?

What happened just shocked me and I just thought perhaps it's some other thing cos I think ireke is somewhat connected to these folks. And these folks can't be trusted. You know I don't like these people - they're all snakes. I can tell you all their alternate handles and they're also the ones crawling to the other side, to snitch out some of our plans on how to move it forward. All they care about is what they can feast on, not the progression of Yoruba people.

I'll come back tomorrow.

Anyway, I'm waiting for you plonkers.

When you're ready for war - shout me.

I'll never forgive you treacherous bastards for what you lot did to that commonwealth thread.

And I'm still watching all of you and ya alternate handles.

Accursed bums and a plague on upstanding Yoruba folks.

I'm out.

---

----

---------

----

----

[s]

Shitmexx:
Shut the f.uck up you Bastard

You are a product of an Illegal immigrant who brought up his brood with benefits and DLA claims (Oh he is now on PIP?)

You are a spoilt brat and a drug addict with no fucki.ng sense. Fucki.ng Bastard

Pu,ssy Hole Informer with no brain

One day the bastard says he is from Lagos and after the next the fuc.cking cu.nt claims Ogun.

Concentrate on messing your brain with drugs like your father

I have seen your pics, you are a ugly bastard just like your dad

You know fu.ckk all about Yoruba tradition. U are a wannabe . Fuc.king pu.ssy hole bit.ch

[/s]

Bwahahahahaha

This is the real shyte-mess.

Don't lie, you were slobbering while typing this, no?

I can't blame you cos ya pops rap3d ya mum to sire you...and ya mum and dad are first cousins. This is what happens with inbreeding, hence you're so incoherent, you stark illiterate.

If you're brave and can show more courage than ya pops ever had - why not post under ya real handle? See my pics? You're a ghost now? - bwahhahaha.

Just fvck off and go suck ya mum. Thanks for the comic relief though, fvcking cun.t.

[img]http://www.aux.tv/wp-content/uploads/2013/02/DrakeMeanMug.gif[/img]