₦airaland Forum

Why are Nigerians this gullible? Is it not obvious that this protest was orchestrated by APC campaign team? Attached, a picture showing the interviewer, buhari's wife and daughter. Am very sure she will get a reward for this. Do you really think Jonathan will rent these kind of people?? Think about this

What did Soludo do when he was in government?? Personally, I don't think he did better than what we have today.

To be honest, FFK is intelligent and he can talk. Good they didn't put him and Amechi together

Breaking News: The Great Oba of Benin Reportedly joins his ancestors. His Royal Majesty Omo n’Oba n’Edo Uku Akpolokpolo Erediauwa, the monarch of Benin Kingdom has joined his ancestors. He was 92 years old.According to authoritative sources within and outside Edo State, the well-regarded king transited to the great beyond about two weeks ago.

His death is still being kept secret because by Benin tradition, the death of an Oba could only be officially announced 30 days after his transition.The Oba was said to have died in his palace. Immediately he was confirmed dead by his personal physician, a delegation of senior Benin chiefs went to the house of the heir apparent the throne, Prince Eheneden Erediauwa to inform him of the development.

Investigations by ionigeria news revealed that the Oba died about two days before the campaign rally of the Presidential candidate of the All Progressive Congress (APC), Major General Mohammadu Buhari in Benin City. Buhari had his rally in Benin City on Thursday, January 29, 2015. That is why the Monarch could not receive Major General Buhari.

Similarly, when President Goodluck Jonathan visited Benin City for his campaign rally, he was only received at the palace by a team of Benin chiefs led by the Iyase, Chief Sam Igbe. Oba Erediauwa was born in 1923, son of Oba Akenzua II.

Before being crowned he was known as Prince Solomon, Aiseokhuoba, Igbinoghodua Akenzua. He attended Edo College, Benin City, Government College, Ibadan then Yaba College, before going to King’s College, Cambridge to study Law and Administration. He joined the Eastern Nigeria Civil Service in 1957 as a District Officer, later moving to the Federal Civil Service where he retired as Permanent Secretary, Ministry of Health in 1973.

For a short period he was the regional representative of Gulf Oil. In 1975 he was appointed Commissioner for Finance in Bendel State during the Military Administration of Major-General George Agbazika Innih.Ascending to the throne as the 38th Oba of Benin on 23 March 1979.

During this period, he several times acted as a peacemaker between politicians. For example, he intervened in a dispute between Abia State governor Orji Uzor Kalu and Tony Anenih, Chairman of the People’s Democratic Party Board of Trustees, and resolved another face-off involving Anenih and former Edo State Governor Lucky Igbinedion.

More recently, he tried to broker peace between the feuding members of Edo State House of Assembly.It would be recalled that his wife, Queen Esther died about a year ago. we made some calls to one or two family members, but they neither refuted nor confirm the story to be true or false.

We therefore believe this has a lot to do with the tradition of keeping quiet for 30 days. so we advise you handle this as speculation until the palace releases its official statement, so we do not offend the traditions of the great Bini kingdom.May his soul rest in perfect peace.

http://www.mjemagazine.com/breaking-news-the-great-oba-of-benin-is-dead/

NIGERIA: INEC CHAMPIONS LEAGUE FINAL

DATE:...14TH FEB, 2015

TICKET: PVC

KICK OFF:...10AM

VENUE:... ESTADIO D' POLLING BOOTHS (Capacity: 68million)

REFEREE:... ATTAHIRU JEGA

ChAMPION- PDP FC:
FORMATION: 5-3-2.
As the Defending Champions, this is a defensive formation in the bid to defend their title..

LINE UP:

1 Jonathan Patience(Gk)
2 N Okonjo-Iweala,
3 David Mark,
5 Edwin Clark,
7 Ayo Fayose(Yellow Card),
8 Godswill Akpabio (midfield maestro),
9 Adamu Muazu,
10 Goodluck Jonathan(C),
11 Namadina Sambo,
15 Gabriel Suswan,
17 Olu Mimiko) Coach: Fix it Anenih

Subs:
23 Fani Kayode (Yellow card)
18 Alison Madukwe Gk
12 Musiliu Obanikoro

CHALLENGER - APC FC FORMATION: 4-3-3
Employs a diamond formation with attacking options and prolific strikers, leading the attack.

LINE UP:

1. Rotimi Amaechi (GK)
2. Bukola Sharaki
3. Raji Fashola
4. Rochas Okorocha
5. John Oyegun
8. Mohammadu Buhari (C)
9. Abubakar Atiku
10 Aminu Tambuwal
11 Bisi Akande
17 Adams Oshiomole
23 Yemi Osinbajo

Subs:
12 John Kayode Fayemi
14 Abike Dabiri
19 Raul Aregbesola
15 Segun Oni
16 Nasir El Rufai. Coach: Bola Tinubu

Match Commissioner: EU Election Monitoring Observers

A match to watch LIVE ... Coming live to your TV stations... Watch and Pray!

This is where I keep having problems with the average Nigerian. Are we supposed to be discussing this guy The father is the cause of the hardship and poverty we are all experiencing today, he has stolen enough for generations unborn, why do we have short memories?? This is the only country where criminals are celebrated.

Please send the milage and last price to opani1@yahoo.com

Dare to be a Nigerian

If you support PDP, you are paid to do so and apparently a thief;

But if you support APC, you are a patriot who is fighting for Nigeria.

If an APC governor award a km of road for N1.2billion, he is prudent and God sent;

If a PDP governor award same km of road for N500million, he is a thief.

If Fani Kayode joins PDP, he is bastard;

If Atiku joins APC, he is a democrat.

If Jonathan spends N7billion for his office par year, he is a criminal;

If Fashola spend same amount in a year, he is a saint.

If Akpabio approves N200Million as pension, he must be stoned;

If Fashola approved N300million for Tinubu he is a change agent.

If you cancelled toll gate as PDP government, you are an enemy of progress;

But if you build a road in Lagos, with tax payers money and toll the road, you are genius.

If you increase school feed as PDP government, you must be crucified;

If you do same as APC government, there must be a reason, cuz Education is not cheap anywhere in the world.

If you share Okada to the poor as PDP, you are poor peoples enemy;

If you ban Okada after election as an APC government, you are only helping the poor to stay alive, so you mean well.

If you single handedly make your daughter a market woman leader in APC state, it is for the progress of the people;

But if your wife is made a permanent secretary in your state by your state government of PDP, you are a greedy fellow.

If you spend N16billion on electricity without power and then support APC, you a navigator;

If you raise N500million through unbundling of same power, you are clueless.

If you fail to pay your workers for a month, but in APC, it is not your fault but someone up there;

But if you failed to pay your worker for a month and still in PDP, you are wicked human being.

If you force your family, in-law and girlfriends as senators and lawmakers on the rest of the party members, you a progressive leader;

But if you act like you don't care in PDP, you are dullard

If you tried to get a third term fraudulently by bribing the legislatures but failed, then support APC, you are democrat and the father of the nation;


If you try to get a constitutional second term in PDP, without their blessings, you an ingrate and silly.

In their time we had Halliburton scandal, ID card scandal, Siemens scandal, we have subsidy scam scandal, we have national stadium contract scandal, we have health budget financial scam, aviation sector scam, we had power sector scandal. How many people did he jail to prove he fought corruption? Rather EFCC was his big stick against his perceived enemies.

In their time we had a sitting governor kidnapped by a thug working for the president. We had a whole region of the country rigged in favor of his party. Morris Ibekwe, a wanted international fraud star won election under PDP.

Those who stole Nigerians blind under PDP; Atiku, Obasanjo, Baraje, Saraki, Wammako, Kwankwaso, Amaechi, Oyinlola, Segun Oni, Okorocha, Ngige, Adeleke, El Rufai, etc, are today the same people financing APC and calling for "CHANGE".

Flashback to 1999, who were these people? Billionaires ? They where nobody. Today, they spend billions and no one dare to ask a question. If you do you are enemy of progress.

They started with "New PDP" when that didn't fly, they joined a cult group called ACN to become APC. Same character with different name.

Sometimes it is better not to be a Nigerian than to be a confused and ignorant one.

Please help me check the VIN of this car 4T1BE30K55U080274 and please send it to bowale4real@gmail.com and opani1@yahoo.com I will show my appreciation as usual.

Thanks

I really appreciate your work. Could you please help me check for: JTEDS41A082047891 and send it to babseg@yahoo.com & opani1@yahoo.com. Kind regards

This is a sad story. I could remember when he came to UNIBEN. may his soul rest in peace

I saw this coming

Congratulations prof! He handled my admission in 2001

Days after the shocking and heartbreaking video of kidnapped US photographer,James Foley being killed was realeased,the US and UK have vowed to find the killer and bring justice. Looks like it didn’t take them too long.They used clues from his eyes and reports from former hostages.. Here is a report by MailonlineIt emerged as reports suggested that British intelligence services had identified the true identity of the terrorist who beheaded Mr Foley – as seen in a video which shocked the world – known as ‘Jihadi John’.A key suspect is 23-year-old Abdel-Majed Abdel Bary, a rapper who until a year ago lived with his family in their £1m home in the affluent London area of Maida Vale,but recently appeared on social media grasping a severed head, an anonymous government source told The Sunday Times.British Special Forces hunting the killer of James Foley are using an array of sophisticated equipment to track him down – and possibly free other hostages being held.In the past 48 hours a ‘significant force’ of SAS soldiers and signallers have deployed to northern Iraq, joining Iraqi and Kurdish units fighting IS.They have separated into four-man teams and are accompanying local troops in an attempt to capture British jihadis, identify them and establish links to Jihadi John.

One SAS source said: ‘It is possible to identify British jihadis on the battlefield by intercepting their radio messages. When they’re captured by the Iraqis or Kurds we’ll take a close interest in their questioning.‘Gathering information such as their blood group and DNA, as well as voice recordings in either Arabic or English, will help us zero in on Jihadi John because it can be compared with existing data.’

http://whispernigeria.net/isis-terrorist-murdered-james-foley-unmasked-special-forces-close-himphotos/

@richyblink:: thank you very much, you have spoken from experience, think this is what I want to hear. Thank you once again

Thank you everyone, I have heard all the inputs.I will take the meaningful and useful advices.thank you

A very big thank you for all the contributions.Like I said my wife was aware before I spent the money, sometimes, we go to site together, I always carry her along in whatever I do. The problem I have with this is not the money, but not trying to sacrifice for the sake of Family, that is my issue. The reason why I mentioned the house rent thing is this, I expected my wife to think and say, oh! We are paying our rent this month, this will not be the best of time to ask for money, also like I said, if my wife had come to me to ask for money without making reference to the 100000 naira, I would have given her twice that amount.I am saying she should stop giving me the impression that she will not sacrifice for the Family.

Thank you everyone

Some one should please tell me the difference between solomon Lar and Lai Mohammed.

Jorussia: i pity GEJ,if northerners really mean am,he will just drown,when he begins to this he is OYO,when impeachment reach national assembly he will realise he has lots of enemies.

You guys are just talking of impeachment. Do you think if they impeach Jonathan this country will be settle? Guys, that will be the end of the Country called NIGERIA

Obtaining drivers liscence in Lagos is now an Herculean task.
I applied in march this year, and was given a september date for capturing.the pictures below was what i met when i got there.

gudugba: You have hearing impairment....

Head ko....throat ni...Olodoo.

Go back to school ..they've called off the strike...they will teach you the difference between heard and head.

Guess you are a graduate!!! you went through school, and school didn't go through you..... so you dont know about "Typo"

Just heard it on Nigeria Info this morning during their cross-fire.
APC has been likened to EGYPTs Muslim Brotherhood that brought Mosi

Northern Elders also said, anything done to substitute Buhari, is a southern Agenda

Does this means the party is dead on arrival?

Three suspected members of a gang that kidnapped the wife, daughter and driver of a Justice of the Supreme Court, Bode Rhodes-Vivour, were on Tuesday paraded by the State Security Service (SSS), alongside other suspected criminals.The suspected kidnappers had in May, this year, kidnapped the two women and the driver in Edo state.Parading the suspects before the state governor, Adams Oshiomhole in Benin, the state capital, the state director of the SSS, Bello Bakori, said the suspects had confessed to the crime and that three members of the kidnappers of the judge’s wife are still at large.He added that Mrs Rhodes-Vivour and her daughter had been kept in a house in Upper Sakpoba area of Benin City from where the suspects were arrested.Justice Rhodes-Vivour’s family was held captive for 18 days by their captors.

Violence erupted here Friday as supporters ofMohamed Morsy turned out en masse in cities around the country, calling for his restoration to the presidency two days after his ouster in a military coup.Five Morsy supporters were shot dead by the army in front of the headquarters of the Republican Guard headquarters, where the ousted president was reported to be detained, the Muslim Brotherhood's political wing -- the Freedom and Justice Party -- said Friday night.The health ministry reported that at least two people were killed and 65 injured in clashes there.The clashes occurred when Morsy supporters tried to storm the building, state broadcaster Nile TV said.Anti-Morsy protesters eye next movesCNN's Reza Sayah, reporting from outside the building, said he had seen one body around which scores of Morsy supporters were huddled, some of them crying.A few feet away, demonstrators faced off across a barbed-wire barricade behind which stood a line of soldiers who detonated flash grenades and fired tear gas in an apparent attempt to get the demonstrators to move away.Morsy supporters turn out en masseSupporters vow to return Morsy to palacePro-Morsy protesters hit with tear gasMuslim Brotherhood remains defiantMany of them did just that, though thousands of others remained in defiance. Demonstrators could be seen carrying away a wounded man. Some demonstrators waved flags and held pictures of Morsy and vowed not to leave until the military returns Morsy to office.But Nile TV, citing a security source, said live ammunition had not been used against demonstrators and no one was hurt or killed.The incidents occurred in the wake of Wednesday's move by the nation's powerful military to remove Morsy from power.Morsy had become the nation's first democratically elected president a year ago, but failed to fix the nation's ailing economy or improve its crime problems and was seen by many as increasingly autocratic.Human Rights Watch has said he had continued abusive practices established by the former dictatorship of Hosni Mubarak, who was pushed out in 2011 after three decades of iron rule supported by the U.S. government. Military courts continued trying civilians; police abuses were allowed."Numerous journalists, political activists, and others were prosecuted on charges of 'insulting' officials or institutions and 'spreading false information,'" the rights group said.Throngs of protesters filled Egyptian streets for days, calling for him to step down.The president's supporters turned out at massive counter demonstrations. At times, the two sides clashed with deadly consequences.On Monday, the army gave him 48 hours to agree to share power or be pushed aside.On Wednesday, the military rejected Morsy's conciliatory gestures as insufficient and announced its "road map" to stability and new elections.Morsy and a number of leaders of the Brotherhood were arrested and may face charges over the deaths of protesters during clashes with Morsy's supporters, many of whom also died.

Amsterdam, The Netherlands, Thursday 25 April 2013: Exciting new data presented today at the International Liver Congress™ 2013 include results from early in vitro and in vivo studies targeting covalently closed circular DNA (cccDNA), which may form the basis of a cure for chronic hepatitis B virus (HBV) infection.

HBV cccDNA is organized into mini-chromosomes within the nucleus of infected cells by histone and non-histone proteins. Despite the availability of efficient therapies against HBV, long-term persistence of cccDNA necessitates life-long treatments to suppress the virus. The following three experimental studies demonstrate effective HBV-cccDNA targeting/depletion using novel therapeutic approaches which offer the potential of a cure.

Liver regeneration induces strong reduction of viral replication and cccDNA levels, but not complete cccDNA eradication; without antiviral treatment, de novo HBV infection can be re-established

Key findings of research[1] in HBV-infected human hepatocytes using the uPA/SCID chimeric mouse system show that liver regeneration induces strong reduction of viral replication and cccDNA levels, with rapid formation of cccDNA-free hepatocytes. However, because complete cccDNA eradication is not achieved, in the absence of antiviral treatment, de novo HBV infection could be re-established in quiescent (non-dividing) human hepatocytes. This suggests that induction of hepatocyte turn-over together with antiviral drugs inducing viral suppression, such as nucleoside analogues and IFN, or blocking cell entry, may accelerate the clearance of the viral minichromosome.

Targeting epigenetic control of nuclear cccDNA minichromosome to suppress HBV transcription and replication may form basis for other therapeutic approaches to curing chronic HBV infection.

In the infected liver cell the rate of replication of HBV is regulated by the acetylation or methylation of histone proteins which surround the cccDNA minichromosome – so called epigenetic regulation. In a separate innovative study[2], the suppression of HBV transcription and replication by small molecules that target the epigenetic control of nuclear cccDNA minichromosome was investigated. The different classes of small molecules studied included: Class I, II and III histone deacetylase inhibitors (HDACi); p300 and PCAF histone acetyltransferases (HAT) inhibitors; hSirt1 activators; JMJD3 histone demethylase inhibitors.

The combined inhibition of p300 and PCAF HATs resulted in an evident reduction of HBV replication which mirrored the decrease of pgRNA transcription. The hSirt1/2 activator MC2791 and the JMJD3 inhibitor MC3119, albeit with different efficiency, inhibited both HBV replication and cccDNA transcription. Results represent a proof of concept that activation of hSirt1 and Ezh2 (through the inhibition of its functional antagonist JMJD3) by small molecules can induce an active epigenetic suppression of HBV cccDNA minichromosome similar to that observed with IFNα, and lead to persistent cccDNA silencing.

Lymphtoxin beta receptor (LTbR) agonisation represents basis for novel alternative therapeutic approach to curing chronic HBV infection

The final study[3] demonstrated that stimulating the lymphtoxin beta receptor (LTbR) provides an effective, long lasting and non-cytopathic mechanism for achieving effective HBV-cccDNA depletion in infected hepatocytes. Cell culture models including HBV-infected HepaRG cells and primary human hepatocytes were used to test the effect of antibodies stimulating human LTbR (BS1 or CBE11). Results show that a strong and dose-dependent anti-HBV effect was achieved by activation of the LTbR. All HBV replication markers were decreased with this treatment, including cccDNA in cells where HBV infection was already established.

Hepatitis B is the most prevalent cause of chronic viral hepatitis and a major global health problem. Prof. Fabien Zoulim, EASL Educational Councillor commented on the exciting new data: “In chronic hepatitis B infection, the viral genome forms a stable minichromosome - the covalently closed circular DNA (cccDNA) - which can persist throughout the lifespan of the hepatocyte.”

“Current treatments focus on suppression of HBV and discovery of compounds directly targeting cccDNA has been one of the major challenges to curing HBV infection; but these preliminary data show novel therapeutic approaches can be applied to successfully target cccDNA with the long-term aspiration of finding a cure” added Prof. Fabien Zoulim.

Disclaimer: the data referenced in this release is based on the submitted abstract. More recent data may be presented at the International Liver Congress™ 2013.
[b]Novel Therapeutic Approches to Cure Chronic HBV Infection
Amsterdam, The Netherlands, Thursday 25 April 2013: Exciting new data presented today at the International Liver Congress™ 2013 include results from early in vitro and in vivo studies targeting covalently closed circular DNA (cccDNA), which may form the basis of a cure for chronic hepatitis B virus (HBV) infection.

HBV cccDNA is organized into mini-chromosomes within the nucleus of infected cells by histone and non-histone proteins. Despite the availability of efficient therapies against HBV, long-term persistence of cccDNA necessitates life-long treatments to suppress the virus. The following three experimental studies demonstrate effective HBV-cccDNA targeting/depletion using novel therapeutic approaches which offer the potential of a cure.

Liver regeneration induces strong reduction of viral replication and cccDNA levels, but not complete cccDNA eradication; without antiviral treatment, de novo HBV infection can be re-established

Key findings of research[1] in HBV-infected human hepatocytes using the uPA/SCID chimeric mouse system show that liver regeneration induces strong reduction of viral replication and cccDNA levels, with rapid formation of cccDNA-free hepatocytes. However, because complete cccDNA eradication is not achieved, in the absence of antiviral treatment, de novo HBV infection could be re-established in quiescent (non-dividing) human hepatocytes. This suggests that induction of hepatocyte turn-over together with antiviral drugs inducing viral suppression, such as nucleoside analogues and IFN, or blocking cell entry, may accelerate the clearance of the viral minichromosome.

Targeting epigenetic control of nuclear cccDNA minichromosome to suppress HBV transcription and replication may form basis for other therapeutic approaches to curing chronic HBV infection.

In the infected liver cell the rate of replication of HBV is regulated by the acetylation or methylation of histone proteins which surround the cccDNA minichromosome – so called epigenetic regulation. In a separate innovative study[2], the suppression of HBV transcription and replication by small molecules that target the epigenetic control of nuclear cccDNA minichromosome was investigated. The different classes of small molecules studied included: Class I, II and III histone deacetylase inhibitors (HDACi); p300 and PCAF histone acetyltransferases (HAT) inhibitors; hSirt1 activators; JMJD3 histone demethylase inhibitors.

The combined inhibition of p300 and PCAF HATs resulted in an evident reduction of HBV replication which mirrored the decrease of pgRNA transcription. The hSirt1/2 activator MC2791 and the JMJD3 inhibitor MC3119, albeit with different efficiency, inhibited both HBV replication and cccDNA transcription. Results represent a proof of concept that activation of hSirt1 and Ezh2 (through the inhibition of its functional antagonist JMJD3) by small molecules can induce an active epigenetic suppression of HBV cccDNA minichromosome similar to that observed with IFNα, and lead to persistent cccDNA silencing.

Lymphtoxin beta receptor (LTbR) agonisation represents basis for novel alternative therapeutic approach to curing chronic HBV infection

The final study[3] demonstrated that stimulating the lymphtoxin beta receptor (LTbR) provides an effective, long lasting and non-cytopathic mechanism for achieving effective HBV-cccDNA depletion in infected hepatocytes. Cell culture models including HBV-infected HepaRG cells and primary human hepatocytes were used to test the effect of antibodies stimulating human LTbR (BS1 or CBE11). Results show that a strong and dose-dependent anti-HBV effect was achieved by activation of the LTbR. All HBV replication markers were decreased with this treatment, including cccDNA in cells where HBV infection was already established.

Hepatitis B is the most prevalent cause of chronic viral hepatitis and a major global health problem. Prof. Fabien Zoulim, EASL Educational Councillor commented on the exciting new data: “In chronic hepatitis B infection, the viral genome forms a stable minichromosome - the covalently closed circular DNA (cccDNA) - which can persist throughout the lifespan of the hepatocyte.”

“Current treatments focus on suppression of HBV and discovery of compounds directly targeting cccDNA has been one of the major challenges to curing HBV infection; but these preliminary data show novel therapeutic approaches can be applied to successfully target cccDNA with the long-term aspiration of finding a cure” added Prof. Fabien Zoulim.

Disclaimer: the data referenced in this release is based on the submitted abstract. More recent data may be presented at the International Liver Congress™ 2013.
[/b]Novel Therapeutic Approches to Cure Chronic HBV Infection
Amsterdam, The Netherlands, Thursday 25 April 2013: Exciting new data presented today at the International Liver Congress™ 2013 include results from early in vitro and in vivo studies targeting covalently closed circular DNA (cccDNA), which may form the basis of a cure for chronic hepatitis B virus (HBV) infection.

HBV cccDNA is organized into mini-chromosomes within the nucleus of infected cells by histone and non-histone proteins. Despite the availability of efficient therapies against HBV, long-term persistence of cccDNA necessitates life-long treatments to suppress the virus. The following three experimental studies demonstrate effective HBV-cccDNA targeting/depletion using novel therapeutic approaches which offer the potential of a cure.

Liver regeneration induces strong reduction of viral replication and cccDNA levels, but not complete cccDNA eradication; without antiviral treatment, de novo HBV infection can be re-established

Key findings of research[1] in HBV-infected human hepatocytes using the uPA/SCID chimeric mouse system show that liver regeneration induces strong reduction of viral replication and cccDNA levels, with rapid formation of cccDNA-free hepatocytes. However, because complete cccDNA eradication is not achieved, in the absence of antiviral treatment, de novo HBV infection could be re-established in quiescent (non-dividing) human hepatocytes. This suggests that induction of hepatocyte turn-over together with antiviral drugs inducing viral suppression, such as nucleoside analogues and IFN, or blocking cell entry, may accelerate the clearance of the viral minichromosome.

Targeting epigenetic control of nuclear cccDNA minichromosome to suppress HBV transcription and replication may form basis for other therapeutic approaches to curing chronic HBV infection.

In the infected liver cell the rate of replication of HBV is regulated by the acetylation or methylation of histone proteins which surround the cccDNA minichromosome – so called epigenetic regulation. In a separate innovative study[2], the suppression of HBV transcription and replication by small molecules that target the epigenetic control of nuclear cccDNA minichromosome was investigated. The different classes of small molecules studied included: Class I, II and III histone deacetylase inhibitors (HDACi); p300 and PCAF histone acetyltransferases (HAT) inhibitors; hSirt1 activators; JMJD3 histone demethylase inhibitors.

The combined inhibition of p300 and PCAF HATs resulted in an evident reduction of HBV replication which mirrored the decrease of pgRNA transcription. The hSirt1/2 activator MC2791 and the JMJD3 inhibitor MC3119, albeit with different efficiency, inhibited both HBV replication and cccDNA transcription. Results represent a proof of concept that activation of hSirt1 and Ezh2 (through the inhibition of its functional antagonist JMJD3) by small molecules can induce an active epigenetic suppression of HBV cccDNA minichromosome similar to that observed with IFNα, and lead to persistent cccDNA silencing.

Lymphtoxin beta receptor (LTbR) agonisation represents basis for novel alternative therapeutic approach to curing chronic HBV infection

The final study[3] demonstrated that stimulating the lymphtoxin beta receptor (LTbR) provides an effective, long lasting and non-cytopathic mechanism for achieving effective HBV-cccDNA depletion in infected hepatocytes. Cell culture models including HBV-infected HepaRG cells and primary human hepatocytes were used to test the effect of antibodies stimulating human LTbR (BS1 or CBE11). Results show that a strong and dose-dependent anti-HBV effect was achieved by activation of the LTbR. All HBV replication markers were decreased with this treatment, including cccDNA in cells where HBV infection was already established.

Hepatitis B is the most prevalent cause of chronic viral hepatitis and a major global health problem. Prof. Fabien Zoulim, EASL Educational Councillor commented on the exciting new data: “In chronic hepatitis B infection, the viral genome forms a stable minichromosome - the covalently closed circular DNA (cccDNA) - which can persist throughout the lifespan of the hepatocyte.”

“Current treatments focus on suppression of HBV and discovery of compounds directly targeting cccDNA has been one of the major challenges to curing HBV infection; but these preliminary data show novel therapeutic approaches can be applied to successfully target cccDNA with the long-term aspiration of finding a cure” added Prof. Fabien Zoulim.

Disclaimer: the data referenced in this release is based on the submitted abstract. More recent data may be presented at the International Liver Congress™ 2013.

Possible cure for Hepatitis B goes to human trials at Texas Biomed

Posted Sunday , April 28,2013Hepatitis B is a disease without a cure. Anyone that contracts it could be left with a chronic, life-long condition that requires ongoing treatment to allow the patient to live a normal life. Like HIV sufferers, they are condemned to be wary of sexual contact, cannot donate blood, and, moreover, are treated with a social stigma. But new research coming out of the Texas Biomedical Research Institute at San Antonio indicates that a Hep B cure could be on the way.A drug developed by Gilead Sciences has proven itself to be able to destroy cells infected with the hepatitis B virus (HBV) in chimpanzees that have the chronic form of hep B. Chimps are the only other primate besides humans that is able to contract a chronic form of hepatitis.The drug is called GS-9620 and is an immune system stimulator. It works with the body’s natural defense system to fight off HBV, eliminate infected cells and reduce the number of infected cells in the liver of the chimpanzees. The success at Texas Biomed with the primates was critical in allowing it to move forward into the human trial phase.A full report of the study co-authored by research scientists from both Texas Biomed and Gilead Sciences can be found in the May issue of Gastroenterology magazine.The drug is not yet a cure, but it promises to be a stepping stone on the way to completely eradicating the disease. The study claims that similar viruses to HBV in other animals can be cured using GS-9620 treatment. The fact that this eliminative potential exists in the drug at all shows that through some minor adjustment, it is possible that aggressive treatments of GS-9620 derivatives could ultimately lead to total dissolution of hepatitis B infections.“This GS-9620 therapy represents the first conceptually new treatment for HBV in more than a decade, and combining it with the existing antiviral therapy could be transformative in dealing with this disease,” said Robert E. Lanford, Ph.D., co-author of the study and researcher at Texas Biomed.

About Hepatitis B

Hepatitis B Virus is a blood-borne pathogen that causes inflammation of the liver. It is often contracted through sexual contact, sharing needles, blood transfusions, and can be passed from mothers to unborn children. It has both acute and chronic strains and can either be a mild illness that leaves after a few weeks, or an ailment that will haunt the sufferer for their entire life.The damage to the liver caused by hepatitis B infection increases the likelihood of cirrhosis, liver disease, and liver cancer. Liver cancer is the third most deadly form of cancer and the fifth most common throughout the world.The Center for Disease Control in the United States claims that there are currently 1.4 million Americans infected with HBV, and many more worldwide where contraceptives and medical facilities are considerably less advanced.The only known way to fight HBV infection is prevention through vaccination.

Link: http://bionews-tx.com/news/2013/04/28/possible-cure-for-hepatitis-b-goes-to-human-trials-at-texas-biomed/

Hello house, something has been bordering me for a long time now, and i dont know if i should continue.
I am a christain, and i believe in God and that christ died for me. Some time ago, out of desperation, i reduced my age by 2years in other to get a job, i finally got the job and i am doing fine on the job, though later on i asked God for forgiveness, but each time i receive my salary, something keep reminding me that i am paying TITHE from the proceeds of a fraudulent act. Please I need reasonable and a man of God's opinion .

Thanks

Guess this is one of the major reasons why people, even some Americans are beginning to think of relocating to one of the Middle East nations. This CAN NOT happen in Dubai or Q'atar

Nigerian Youths wake up, We have no other country except Nigeria, We have been suffering in silence while our Leaders put our future in their bank accounts. How can we remain like this? How can a youth go to school and suffered to graduate at the end no job. You are almost 40 and still your future is as bleak as a dark room. Did your parents send you to school to sit at home because our Government have failed us. Let us come out one day and say No. We must not remain like this, we cannot all travel abroad to find a better life, our better life is here in our country. We have the money, oil and resources but only a selected few have continue to suck it dry why we keep believing God for a change, wake up now I challenge you. We need 500,000 youths in each of the 36states to challenge the Government. We say NO, we will destroy this country and rebuild it afresh, we will Kill those who stand on our way as they are consideredthe enemy. A man cannot have billions of naira while millions of youths roam the streets every day looking for daily bread. Our young men must not all be kidnappers, our young girls must not all be prostitutes. Get Ready I tell you. The time has come for us to react, the only way our Government listens is violence,they have shown it to the Niger delta militantsand nowthey are planning to show it to the boko haram..whereas a simple gesture of N20,000 per monthto the unemployed was rejected and you pay militants N75,000 per month. How much do they pay as minimum wage? How much do they pay to elected officers, we are going to revolt. Nigeria will burn to berebuilt again like Libya, Iraq, Egypt and Tunisia...pleas e spread this message unless you want todie in poverty in a country where God has destined all of us to be happy and prosperous...!! ! Pls send this msg to all ur contact cos anytin can happen o!!! The time is right for us all to say no bad governance who take the youths for granted!
I knw sum will say NO let start the move together by joining the group "nigerian youths movement for revolution"pls don't send friend request just like the group "nigerian youths movement for revolution" help us in recommending the group to ur family and friend say no to bad leaders, say no to oppressors

I love Stella, mehn. She no send...lol. See her response to Mercy Aigbe's press statement below..
As you read this, Mercy Aigbe and hubby and some close friends are in a room in his hotel arguing heatedly and asking Mercy to go down on her knees and beg hubby for what happened on Sunday Night April 7th, 2013, in Lagos Nigeria.
So...where was I?
Funke Oluwole....(whats your last name?Mrs....?) I really didnt want to start this week writing memos because i have written enough to see me through the week.
I saw the first press release and i ignored it because it was official and properly done..yours smirks of I-Too-knowism so i will bother you with a response..not that i stand to gain anyting by replying you Egbon Agbaya. (wait oh,why una dey send two press release sef?any more coming?)
Lol. Please continue...


I saw your supposed press statement concerning the matter and i checked the dictionary,yes you are on point,all the words you used to describe me exist there....clap for yourself. I will not bother you with a-so-long-a letter response because no need abeg,you are too deep in the well of lies you represent to believe anything else.
Let me ask you one question before i proceed..Did you ask around before you drafted that shopping list addressed to me?
did you know that i have received the 100th call of Insiders begging me to spill the name of the rat who leaked the info?
Did you know that i was asked to quickly delete the story before it would be copied by other bloggers and i almost did before i saw that it was too late to delete?did you that i knew when the press release was being drafted and i said i would not respond because i gain nothing from doing a response to every press release?
You didnt?..so nah who send you to respond?
I guess your loyalty to covering up lies and perhaps seek gratification later for a job well done pushed you?..I understand,we have been on that boulevard and its full of pot holes. I was actually waiting for the supposed media people at the event to report what they saw,i actually waited till this afternoon and saw that there had been a cover up....you call me a myopic blogger who dishes out lies?My job is to tell stories and stick by them if i lie not!
Funke..Foluke(Errm whats your name again?)
I lie because I wrote what happened yesterday and you speak the truth because you sent out a press release calling me out?A press release embedded in lies?Okay paro lo! Contrary to your diarhea mind,i have nothing against mercy..A story is a story and they did come out to debunk it which was fine till you came out to do your own I too know to show you went to school.
I have finished addressing you and my last word to you is bring out all your degrees and chew them up like a rat will,,chew them up before that rat finds it. Now to the matter on ground.
If the people involved in my story are denying that it happened,please this is a stern warning to all the callers,I WILL NOT RAT ON MY SOURCE WHO IS ONE OF YOU and even involved in the first press release,I understand that every story must come with a press release and i doff my heart for the first one properly sent out calling on to her fans to disregard the report..i am one of mercy's fans and i used the other cheek to disregard the story that what happened didnt.

I didnt say that Mr Gentry pummelled his wife last night,i said i hope he has not pumelled her...and even if i did say so,abi una dey find my mouth?

If they are denying the story, why did Mercys hubby compell the MC, Soji Omotayo to announce his wife's whereabouts, it was obvious that, Larry didn't know anything about the room being given to his wife to change?sleep?to do what exactly? Didnt Mercy tell her husband that she was going to use the toilet and it took her husband to forcefully barge into the room before she came out?

one of the staff at Troy confirmed that the Hubby who had drank a little too much was so mad that he didn't pay his remaining bill of N6000 for the drinks he bought for friends and foes.
Wasnt one of Mercy's friend/fan who came from the UK  so disappointed that she complained bitterly to the hearing of many and  said so many things whilst waiting for Mercy beside the Solaria car she brought.

Wasnt the car hurriedly driven from the venue after my story came out?The car that wouldnt start last night started as soon as the key was turned in the ingnition....No i was not there but Journalism now has legs and eyes! Why has there been a meeting of close friends trying to intervene in what happened yesterday if nothing happened?
My source still confirms that the short sexy black dress worn by Mercy is still missing,na who hide am?Please let us know if it is found otherwise I would declare that the dress was stolen off her that was why she changed and vanish or vanished and changed...whichever comes first.
You ask for proof of picture?I actually have a pic of the white 'thing'she changed into but No i will not upload it because i will not it is that simple.
If you do not want anyone to see your pants,do not wash them in public please...I wish the reporters who witnessed this incidence yesterday will be bold enough to come out and support me....Thats wishful thinking,the fear of men and the love for money has turned journalists into cowards who report only half baked stories to suit the people who pay their bills.
Mercy Aigbe-Gentry and hubby should please go indoors and settle this matter peacefully...I am at least happy that my story has stopped this incident from escalating further.
I have my own cupboard of skeletons and i am not proud to open others...At the end of it all God is the ultimate judge and forgiveness is what we seek.
I wish Mrs and Mrs Gentry well and urge them to keep it indoors next time!