₦airaland Forum

Ajibam: thirded

Confirmed.

Deep Sight: Lol, that is not always to be taken seriously. Jibes, really.

ok o. if you say so

EzePromoe is proof enough that we don't need atheist topics on FP. his type are all over the FP, happy and proud in their stupidity and ignorance.

texanomaly: Interesting stuff.

Yep. this is what Science does. look for practical and workable solutions to human problems, Not...

MODs pls review and recommend for FP. thanks

https://www.nairaland.com/1513743/breakthough-treatment-cancer-curing-leukaemia

holypower: do you think that you should be alive by now ? It is the sacrifice of CHRIST that made you alive today because we are in the time of grace...you are going to experience greater and everlasting punishment if you don't believe that CHRIST is the LORD.....

When you see yourself in hell then you will know that CHEIST is the LORD and that HE has the power to destroy and to save you.

So people that died?


All these your hellfire threats are so lame and childish. grow up y'all. ignorant slaves

http://www.youtube.com/watch?feature=player_embedded&v=dVvEIYlj_wA

http://www.youtube.com/watch?feature=player_embedded&v=dVvEIYlj_wA

this 4 minute video shows an inspiring story of a young girl, Emma who was cured of Leukaemia by injecting her with HIV-modified T-Cells which were then capable of attacking the cancer cells.


It is important though to get the correct information on how it was actually done...

No, doctors did not “inject HIV into a dying girl” to treat her cancer

Posted on June 25, 2013 by Kat Arney


We’ve recently noticed an inspiring short film circulating on the internet about how doctors in the US have apparently cured a child of leukaemia by “injecting her with HIV”.

But while the actual science behind this story is fascinating, the treatment is still at an extremely experimental stage and has only been tested in a handful of patients.

And while we’re always keen to welcome exciting experimental cancer treatments, we also want to clear up a few misconceptions about what the research actually involved.

To be absolutely clear, the doctors in the video did NOT inject HIV – nor a “deadly disease” – into a child.

So who are these people, and what did they actually do?



Turning the immune system on cancer

The research comes from Professor Carl H. June and his team in Philadelphia in the US. He’s a highly-respected scientist working on cancer, HIV and the immune system, and has published his work in hundreds of papers in many leading scientific journals over several decades.

The immune system is an incredibly hot topic in cancer research. Cancer is an illness that starts from our own cells going rogue within us. Our immune system is pretty good at recognising and attacking foreign invaders – such as bacteria or viruses – but it doesn’t do so well at tackling tumours.

A huge amount of research effort around the world is focused on trying to understand why the immune system doesn’t recognise and fight off the disease. And there’s also a lot of work aimed at harnessing this powerful force for treating cancer, and this is leading to new ways to treat the disease.

Professor June and his team are taking an interesting approach to this challenge. In particular, they’re developing new ways to turn the power of the immune system on leukaemia – a cancer caused by white blood cells (usually B cells, also part of the immune system themselves) growing out of control.

They’ve developed a technique in which they collect special ‘killer’ immune cells, called T cells, from a cancer patient. These are then ‘reprogrammed’ in the lab using a modified virus, which is very good at smuggling genes into the T cells.

In this case, the researchers added genes carrying instructions that tell the T cells to make a new protein called a “chimeric antigen receptor” – this lets them lock on to molecules found on the surface of cancer cells, killing them in the process.

These reprogrammed T cells are then injected back into the patient, where they grow and multiply, creating an army of killer cells to fight the disease.

At least, that’s the theory.

From the lab to the clinic

The Philadelphia team has been working on this technique for many years, developing it first in the lab then testing it in animals with promising results. They’re now taking this a step forward, into clinical trials with cancer patients.

The situation described in the video, where a little girl called Emily Whitehead (referred to as Emma in the film) undergoes modified T cell treatment, isn’t the first time this approach has been tested in people. There’s more than a decade’s worth of data looking at the safety and effectiveness of virus-modified T cells in clinical trials for treating people with HIV as well as cancer.

In 2011, Professor June’s team treated three adults with chronic lymphocytic leukaemia (CLL) with virus-modified immune cells as part of a small, early-stage clinical trial. All three had undergone several rounds of chemotherapy, yet their cancer kept coming back. For two of them, their cancer completely went away after the T cell therapy – something known as “complete remission”. This was an important and impressive result, although one that was probably over-hyped in the media at the time.

Further results from the trial – totalling 10 adult patients with CLL and two children with a different type of leukaemia (acute lymphoblastic leukaemia, or ALL) were announced at a scientific conference at the end of 2012. The researchers claimed that nine out of the twelve patients had been treated successfully – presumably three of the adult patients are from the 2011 paper, while the two children are likely to be from the paper we’ll discuss shortly.

And in March this year, a team at Memorial Sloan-Kettering Cancer Centre in New York published results testing a similar approach in five adults with ALL. In all five, the cancer vanished, although four of them went on to have further treatment so it’s hard to say whether this therapy was solely responsible for curing them. And for the final patient, the cancer came back once the reprogrammed T cells had died off in their body.

From what we can tell, the girl in the video – Emily/Emma – is being treated as part of another small-scale, early-stage clinical trial for children with leukaemia and lymphoma, testing the virus-modified T cell treatment. This is primarily a trial to find out whether the treatment is safe, rather than how well it works.

Results from two children with ALL were recently published in a paper in the New England Journal of Medicine. Of the two kids, one seems to have had a complete remission – we can only assume this might be Emily, though she isn’t mentioned by name in the paper. Sadly, the other child didn’t do so well. The cancer came back just two months after the T cell treatment.

Obviously, for Emily and her family this experimental therapy has been nothing short of a miracle. But from the handful of cancer patients treated so far, it’s clear that it doesn’t work for everyone – something that’s rightly pointed out in the film.

The therapy also causes significant side effects, dramatically described in the video. Several of the patients who receive the modified T cells seem to experience what’s known as a “cytokine storm” – a potentially fatal immune reaction. Subjecting weakened cancer patients to such a barrage is highly risky, so researchers need to proceed with great caution as the clinical trials continue recruiting patients.

How does HIV fit into the picture?

Promoting the video, the Upworthy website boldly states that the doctors are injecting “HIV into a dying girl”, and that she received a “deadly disease”. This is a serious bending of scientific truth, and very misleading.

In fact, the researchers are using a type of virus called a lentivirus to reprogramme the T cells. This family of viruses – of which HIV is a member – are particularly skilled at sneaking into cells and embedding their genetic code within the cell’s DNA. Unsurprisingly, this makes them a good vehicle for smuggling in the genetic instruction telling T cells to attack the cancer.

According to the video, Professor June says that the virus used in these experiments was originally derived from HIV, and we hear the film-maker asking off-camera “So you’re taking the HIV virus and infecting healthy cells with it to help kill cancer?” However, the virus has undergone significant genetic tinkering, meaning that it is no longer harmful (as June does go on to explain). And it’s arguable whether it should even be referred to as HIV at all, given how much it has been altered.

And the researchers didn’t inject any virus into anyone. As we’ve explained, they took immune cells out of the patient, treated them with the virus in the lab, then injected the modified cells back in.

[size=18pt]To sum up[/size]

Broadly speaking, we feel that this film is inspiring, and we’re always happy to see the fruits of promising new therapies for cancer. But to promote “injecting HIV” as a treatment is misleading.

One child surviving ‘incurable’ cancer is an amazing event, but there is a lot more work to be done to find out how best to use this new technology. At the moment it’s still highly experimental and expensive. It’s only being trialled in a very small number of patients, primarily to make sure it is safe, and so far we’ve seen that it doesn’t work for everyone.

In the case of the child whose cancer came back after treatment, the researchers found that her cancer cells had somehow stopped carrying the T cells’ target molecule. So it’s likely that other targets will need to be identified, to make the treatment more effective for more patients in the future.

On a positive note, there’s no reason why this type of treatment should be restricted to cancers affecting the immune system (namely leukaemia and lymphoma), although they’re much more accessible to the killer T cells. Researchers elsewhere are investigating how to target a range of different types of cancer with this approach.

There are several similar therapies being tested in the lab and in clinical trials around the world, including in the UK. And Cancer Research UK scientists are finding out whether harmless genetically-engineered viruses could be used as therapeutic vaccines, training the immune system to seek and destroy cancer cells.

It’s still early days for these exciting new approaches and there are many hurdles to jump, but we’re looking forward to the day when they can be used to treat patients on a wider scale.

http://scienceblog.cancerresearchuk.org/2013/06/25/no-doctors-did-not-inject-hiv-into-a-dying-girl-to-treat-her-cancer/

macof: No the Gods are only trying to reclaim their land from Yahweh and Jesus.

These Philippines have a covenant with them and they must fulfill the covenant.

Africa is next, You atheist are spared but The Abrahamics who worship another foreign God shall see the wrath of THE GOD which their ancestors swore to

in other words they're Jealous and Petty?

Fighting over their right to be worshipped?

Funny Funny people.

pastormustwac: One common aspect that strikes me across all religions is that they provides hope, or meaning, or the assurance of the love of God, and that taking away a person's religion would be cruel because you are taking away their hope.

This is because man cannot live in a state of hopelessness (for this is the final spite - for those that understand what that means).


This is a very key factor to a lot of things, let's look at a few issues:

1. The runner that refuses to wear 666 bib, fears that if he wears that, he believes he will loose the hope of salvation and probably end up in 'hellfire' as they say. And so forfeited the race for that reason. Be that as it may, whether he did the right thing or not, does not concern me = he, like all men, chose his fate.

2. Those that are religious fanatics have so much believed in the illusion (or maybe delusion) that their religious practices shall give them all they hoped to achieve in this world and/or the next - like virgins waiting, entering heaven and all that.

I shall stop here to avoid stepping on too many toes.

What will happen if these religions are devoid of hope and show that all men have a common fate no matter their religion? Just wondering. . .

then we will all bend down and work. we will make sure that we leave this world a better place than we met it. our eternity will be the legacy we left for our unborn generation. we will fight oppression, injustice and prejudice against every human wherever they may be found...no waiting on any skydaddy to come and wipe everything...

Ajibam and Josh who worse pass?

macof: It is the gods of their ancestors, gods of Philippines that is punishing them for worshiping Yahweh and Jesus.

It would soon get to Nigeria.

Repent Repent Repent and acknowledge the God of your land and God of your people

ARE THE GODS SO LONELY , PETTY, JEALOUS AND NEEDY?

so much for the Omni Omni deities.

ghostofsparta: It's because of this sort of thinking folks keep hoarding and hiding these esoteric knowledges from knowledge seekers like me. My pal who I've spoken of on this thread also told me that because of his sudden burst of interest after the teleporting demonstration her Christian converted granny showed him yesterday, she immidiately went further to burn whatever remaining parch books she has written on her own YAS. In my own town, in our lineage, one old powerful YASist went very far away to bury his box of juju powers and knowledges, when asked why, he said youths nowadays (then) don't have the required patience (suru) and necessary understanding of knowing when to apply them in that so dire a moment. I'm sure he was referring to someone like you.

see man, this here is why you guys will never be taken seriously.

i'm out.

texanomaly: *walks into thread. Slaps Mr. Troll. Grabs him on either side of his face. Kisses him soundly on the mouth, and walks out*

Joshthefirst: sorry, I don't respond to people who publicly show their immaturity by choosing to only mock what they do not believe in.

Do you see mazaje cussing or mocking?
Do you see rationalmind cussing?

Its pathetic. I won't waste words.

You make it difficult not to be cussed. it is a pathetic waste of time arguing with you about religion.

Joshthefirst: I was making a joke....

texanomaly: Nope...If y'all are done beating it, I thought I would bury the poor thing.

see the explanation. the 'joke' was off point.

Joshthefirst: *blocks her path, asks her: "what are you doing with that dead horse ma'am?! Surely you don't want to eat it!"*

'dead horse' is an idiomatic expression....

texanomaly: So if the schools are so bad, how does anyone get into university?

examination malpractice. corruption cuts across all sectors of the nation.

GhostofSparta is one funny dude.

people walking through walls? yet bank vaults are still intact and safe?

Deep Sight: What? The truth doesnt become me?

Commot dia joor

no. the unnecessary pot shots.

the truth?

MyJoe: This must be one of them private schools. So what happens when you answer that you are not born again?


Sure. Great.

nope. it was, and still is a govt owned university. one of the first in the country

like I said, I didn't bother asking questions in his class. no time for long talk...

texanomaly: If you believed in it, you would be too.

does that mean you don't believe in hellfire?

Joshthefirst: not just you sir, God enjoys straightforward prayers.

He gets tired of listening to repeatitive nonsense sometimes. He likes prayers from the heart.

Behold, the PA of GOD!!!

^^^

Josh: We know the reality of God's word. Its evident in our lives. No other religion saves man from sin and death. Accept Jesus today so that you don't go to hell. . .

If you have any more questions, reread the first answer.

Deep Sight: ^^^^ Thank you o.

I am only mildly surprised that you waste your energy to explain the glaringly obvious to a willfully deluded old man wallowing in absurd perversity.

Really man? This does not become you DS.

Anyway, make i just de observe. . .

Joshthefirst: yes, but I don't do uniform reading most times. I've read portions of the bible and the epistles several times. I used to do uniform reading before, but I don't do that now.
I don't really take time records.

Have you read the bible cover to cover. Your answer was not clear. See Tex's answer. Clear and concise.

@Tex, you found absolutely nothing amiss with the character of the old testament Yahweh?

Edit: Don't answer that Tex.

Have you read the bible cover to cover? Be sincere now. How long did it take you?

FOLYKAZE: They are scared of Osanyin.....just like kid scared of bullman.

They are free to investigate and verify there points but non can come forward for that. Smh for this childishness and cowardice

You sound like a kid. I asked you simple questions and you are here ranting. Rationalmind has at least made an attempt to answer. I live and work in PH. You don't expect me to run all the way to Lagos for a spurious claim you can't even properly explain. Do you even understand what is called reasonable doubt? Do you know how the Achmed video works?
Don't expect anybody to take you serious if you call yourself an atheist and then can't answer simple questions rationally.

Stop wasting my time, i'm done with you.

texanomaly: @ Mr. Troll

Smiling indulgently, while smh.

Come to Nigeria. Nollywood has got nothing on us.

texanomaly: 2 weeks first visit.

Oh. Seems quite short. I hope you do walk around. Pay particular attention on sundays. . .

FOLYKAZE: Nairaland atheist are people Ebenezer obey was refering to in his song titled 'baba oni ketekete'. No matter what you do to please them, they cant be satisfied.

The door is open for you to answer Ghostofsparta and debunk him. Other you say here is trash.

You didn't answer any of my questions.