Patani's Posts
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I paid over 1mill for 2bed in Ogudu. The land lady daughter still wan dey ride me... I top say she old pass me |
Biglittlelois:Ratio? |
Kufie:I will sell yu my Dads Nissan Altima for 500K i inported it from America myself very sound and neat..Quote me if you want it |
rockstarB:What you read online is usually not tru reflection of reality... Beeing confortable is the most important thing at home... Most men who were already made before their first marriage are jerks who has little or no respect for women... |
lekjons:Exaclty, Nigerians and stupidity.. Siri is just not loaded with appropriate info.. Google assistance do better... Been an iPhone user.. Not going that lane anytime soon |
170k Pere!!! That's 500USD per month..Owo ta won kan fi shaye lojo Friday...U allow it to enter ur head and start misbehaving to your partner who is supposedly meant to stay with you in your old age. |
Good news |
Gilead Announces Results From Phase 3 Trial of Investigational Antiviral Remdesivir in Patients With Severe COVID-19 -- Study Demonstrates Similar Efficacy with 5- and 10-Day Dosing Durations of Remdesivir -- FOSTER CITY, Calif.--(BUSINESS WIRE)--Apr. 29, 2020-- Gilead Sciences, Inc. (Nasdaq: GILD) today announced topline results from the open-label, Phase 3 SIMPLE trial evaluating 5-day and 10-day dosing durations of the investigational antiviral remdesivir in hospitalized patients with severe manifestations of COVID-19 disease. The study demonstrated that patients receiving a 10-day treatment course of remdesivir achieved similar improvement in clinical status compared with those taking a 5-day treatment course (Odds Ratio: 0.75 [95% CI 0.51 – 1.12] on Day 14). No new safety signals were identified with remdesivir across either treatment group. Gilead plans to submit the full data for publication in a peer-reviewed journal in the coming weeks. “Unlike traditional drug development, we are attempting to evaluate an investigational agent alongside an evolving global pandemic. Multiple concurrent studies are helping inform whether remdesivir is a safe and effective treatment for COVID-19 and how to best utilize the drug,” said Merdad Parsey, MD, PhD, Chief Medical Officer, Gilead Sciences. “These study results complement data from the placebo-controlled study of remdesivir conducted by the National Institute for Allergy and Infectious Diseases and help to determine the optimal duration of treatment with remdesivir. The study demonstrates the potential for some patients to be treated with a 5-day regimen, which could significantly expand the number of patients who could be treated with our current supply of remdesivir. This is particularly important in the setting of a pandemic, to help hospitals and healthcare workers treat more patients in urgent need of care.” Remdesivir is not yet licensed or approved anywhere globally and has not yet been demonstrated to be safe or effective for the treatment of COVID-19. This study sought to determine whether a shorter, 5-day course of remdesivir would achieve similar efficacy results as the 10-day treatment regimen used in multiple ongoing studies of remdesivir. Secondary objectives included rates of adverse events and additional measures of clinical response in both treatment groups. Patients were required to have evidence of pneumonia and reduced oxygen levels that did not require mechanical ventilation at the time of study entry. Clinical improvement was defined as an improvement of two or more points from baseline on a predefined seven-point scale, ranging from hospital discharge to increasing levels of oxygen support to death. Patients achieved clinical recovery if they no longer required oxygen support and medical care or were discharged from the hospital. In this study, the time to clinical improvement for 50 percent of patients was 10 days in the 5-day treatment group and 11 days in the 10-day treatment group. More than half of patients in both treatment groups were discharged from the hospital by Day 14 (5-day: 60.0%, n=120/200 vs.10-day: 52.3% n=103/197; p=0.14). At Day 14, 64.5 percent (n=129/200) of patients in the 5-day treatment group and 53.8 percent (n=106/197) of patients in the 10-day treatment group achieved clinical recovery. Clinical outcomes varied by geography. Outside of Italy, the overall mortality rate at Day 14 was 7 percent (n=23/320) across both treatment groups, with 64 percent (n=205/320) of patients experiencing clinical improvement at Day 14 and 61 percent (n=196/320) of patients discharged from the hospital. Impact of Earlier Treatment In an exploratory analysis, patients in the study who received remdesivir within 10 days of symptom onset had improved outcomes compared with those treated after more than 10 days of symptoms. Pooling data across treatment arms, by Day 14, 62 percent of patients treated early were able to be discharged from the hospital, compared with 49 percent of patients who were treated late. “These data are encouraging as they indicate that patients who received a shorter, 5-day course of remdesivir experienced similar clinical improvement as patients who received a 10-day treatment course,” said Aruna Subramanian, MD, Clinical Professor of Medicine, Chief, Immunocompromised Host Infectious Diseases, Stanford University School of Medicine, and one of the lead investigators of the study. “While additional data are still needed, these results help to bring a clearer understanding of how treatment with remdesivir may be optimized, if proven safe and effective.” Remdesivir was generally well-tolerated in both the 5-day and 10-day treatment groups. The most common adverse events occurring in more than 10 percent of patients in either group were nausea (5-day: 10.0%, n=20/200 vs. 10-day: 8.6%, n=17/197) and acute respiratory failure (5-day: 6.0%, n=12/200 vs. 10-day: 10.7%, n= 21/197). Grade 3 or higher liver enzyme (ALT) elevations occurred in 7.3 percent (n=28/385) of patients, with 3.0 percent (n=12/397) of patients discontinuing remdesivir treatment due to elevated liver tests. Key efficacy and safety results from the study are included in the table below. 5-Day RDV 10-Day RDV Baseline adjusted n=200 n=197 p-value1 Clinical Efficacy Outcomes at Day 14 ≥ 2-point improvement in ordinal scale 129 (65) 107 (54) 0.16 Clinical recovery 129 (65) 106 (54) 0.17 Discharge 120 (60) 103 (52) 0.44 Death 16 ( ![]() 21 (11) 0.70 Safety Any adverse event (AE) 141 (71) 145 (74) 0.86 Grade ≥3 study drug-related AE 8 (4) 10 (5) 0.65 Study drug-related serious adverse event (SAE) 3 (2) 4 (2) 0.73 AE leading to discontinuation 9 (5) 20 (10) 0.07 1Adjusted for baseline clinical status About the SIMPLE Trials Gilead initiated two randomized, open-label, multi-center Phase 3 clinical trials for remdesivir, the SIMPLE studies, in countries with high prevalence of COVID-19 infection. The first SIMPLE trial is evaluating the safety and efficacy of 5-day and 10-day dosing regimens of remdesivir in hospitalized patients with severe manifestations of COVID-19. The initial phase of the study randomized 397 patients in a 1:1 ratio to receive remdesivir 200 mg on the first day, followed by remdesivir 100 mg each day until day 5 or 10, administered intravenously, in addition to standard of care. An expansion phase of the study was recently added and will enroll an additional 5,600 patients, including patients on mechanical ventilation. The study is being conducted at 180 trial sites around the world, including sites in the United States, China, France, Germany, Hong Kong, Italy, Japan, Korea, the Netherlands, Singapore, Spain, Sweden, Switzerland, Taiwan and the United Kingdom. A second SIMPLE trial is evaluating the safety and efficacy of 5-day and 10-day dosing durations of remdesivir administered intravenously in patients with moderate manifestations of COVID-19, compared with standard of care. The results from the first 600 patients of this study are expected at the end of May. About Remdesivir Remdesivir is an investigational nucleotide analog with broad-spectrum antiviral activity both in vitro and in vivo in animal models against multiple emerging viral pathogens, including Ebola, Marburg, MERS and SARS. In vitro testing conducted by Gilead has demonstrated that remdesivir is active against the virus that causes COVID-19. The safety and efficacy of remdesivir for the treatment of COVID-19 are being evaluated in multiple ongoing Phase 3 clinical trials. About Gilead Sciences Gilead Sciences, Inc. is a research-based biopharmaceutical company that discovers, develops and commercializes innovative medicines in areas of unmet medical need. The company strives to transform and simplify care for people with life-threatening illnesses around the world. Gilead has operations in more than 35 countries worldwide, with headquarters in Foster City, California. For more information on Gilead’s response to the coronavirus outbreak please visit the company’s dedicated page: https://www.gilead.com/purpose/advancing-global-health/covid-19. Forward-Looking Statement This press release includes forward-looking statements, within the meaning of the Private Securities Litigation Reform Act of 1995 that are subject to risks, uncertainties and other factors. Remdesivir is an investigational agent that has not been licensed or approved anywhere globally, and it has not been demonstrated to be safe or effective for any use, including for the treatment of COVID-19. There is the possibility of unfavorable results from ongoing and additional clinical trials involving remdesivir and the possibility that Gilead and other parties may be unable to complete one or more of such trials in the currently anticipated timelines or at all. Further, it is possible that Gilead may make a strategic decision to discontinue development of remdesivir or that FDA and other regulatory agencies may not approve remdesivir, and any marketing approvals, if granted, may have significant limitations on its use. As a result, remdesivir may never be successfully commercialized. All statements other than statements of historical fact are statements that could be deemed forward-looking statements. These risks, uncertainties and other factors could cause actual results to differ materially from those referred to in the forward-looking statements. The reader is cautioned not to rely on these forward-looking statements. These and other risks are described in detail in Gilead’s periodic reports filed with the U.S. Securities and Exchange Commission, including current reports on Form 8-K, quarterly reports on Form 10-Q and annual reports on Form 10-K. All forward-looking statements are based on information currently available to Gilead, and Gilead assumes no obligation to update any such forward-looking statements. For more information about Gilead, please visit the company’s website at www.gilead.com, follow Gilead on Twitter (@GileadSciences) or call Gilead Public Affairs at 1-800-GILEAD-5 or 1-650-574-3000. View source version on businesswire.com: https://www.businesswire.com/news/home/20200429005424/en/ Source: Gilead Sciences, Inc.
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Moneystopnonsen:God bless you! |
Confusedwomsn:Do you know what they call submission in marriage? I am not sure... Submission can turn any beast of a man to the mumuest man you can imagine... You are telling your husband to wash his cloths and u expect him to behave like Norman husband? You are a jocker... I am not boasting or anything but I have one of the best home or marriage I av seen anywhere.. The truth is, I am an idiot n rude individual... But the level of humility n respect my wife have for me? I will never ever treat her bad cos even eternity will not forgive me... It's a woman that makes a home.. If u expect him to respect you first trust me ur in it for a shock.. Just telling u a fact.. Anyone can have thier own 'modern' view which has proved to be fatal to marriages and homes nowaways anyways.. That thier problem. My kne kobo |
Rilwayne001:You totally summarize my conviction here... Dreams are just brain activities while we sleep... Putting meanings to them make us have more of that encounter... Kudos.. Logical thinkers rule the world bro! |
candyguyofficia:Same situation I av found myself.. Sigh.. Wishing I could give my father befitting burial... |
Stop kneeling for women to marry u.. Its unafrican... No be everything white man do we go dey copy... Thats wat they call inferiority complex.. Spit |
ednut1:May God bless you... |
Another 2019 nairaland super story |
Ineedtoheal:People that call Nigerian girls out have never been outside the shores of Nigeria... I av seen many attitude frm other African women and I have no option than to call Nigerian women Queens, mothers and home builders... Go to countries like SA and other southern African countries. Na women dey use n dump men. |
Unserious:Now i see you are an slowpoke.. I cease to answer you going forward... Cunt |
Unserious:Do you have comprehension problem? I said its like you making such statement |
Officialgarri:You are totally wrong.. Making these kinds of statements on public domain can not be overlooled without questions... Its as if you go out on your street shouting 'I am a rapist', thiking u av freedom of speech in public domain... Eventhough you do, you should still be arrested and questioned before we know u are just making unserious statement.... Who knows if the pervert has been going around molesting boys... If u av a son of that age may be u will understand.. They need to question him |
TAG4:Well, I was on and off for about 2years..if you know wat I mean... 2months straight I give perfect performance and then I relapse 1month... I get back on track by excersise n mind control.. But now... I'm just constantly a champion.. Wifey was still sqirting all over son of man yesternight... Heheheh... Anyways, I understand ur fear but don't put him under pressure... Just let him know ur desire.. But before mariage performance is not a criteria as long as the man make desire to improve by not eating junks, exercise and control mind.. Sex is important in mariage but not everything.. Alot of Bleep boys give good sex but will make your life miserable... A good man with proper support n rest of mind will eventually become a champion in bed... Wish you all the best in this journey and remeber there are different phases in marriage. God will see u tru |
GboyegaD:We will continue to blame leadership rill eternity... Our own dey our body |
GboyegaD:Maybe if you have been to other countries u would understand wat i am saying... Sometime a little patriotism and love for the country does some wonders in making a country great... Wen u get to some countries, you would realize that's it's nt that thier government is fantastic., but people av this sense of 'let's make our country a livable place'... We need to take some responsibility as people... We love chaos and lawlessness |
GboyegaD:Aw many people av been used as detergent? Na citizens like you and I go still collect bribe leave the guy latter |
GboyegaD:There is no government anything here... We are all crooks... Is it government that will make u to use ur gumption not to destroy a property meant for millions of people? |
NextD18:One cold beer for you for speaking the ugly truth |
South Africa Health Minister Dr Zweli Mkhize has confirmed that South Africa has recorded its first positive test case for the Covid-19 coronavirus. Mkhize released a statement on Thursday confirming that the National Institute for Communicable Diseases (NCID) confirmed a positive test. While it was not clear at which port of entry the patient landed, Mkhize said that a tracer team has been deployed to KwaZulu-Natal. The man is now self-isolated. "The patient is a 38-year-old male who travelled to Italy with his wife. They were part of a group of 10 people and they arrived back in South Africa on 1 March," Mkhize said in the statement. Play Video 1m 13s Wuhan doctor recounts anxiety and fears from virus frontline One month after makeshift hospitals were set up in the Chinese city of Wuhan to cope with the coronavirus outbreak, frontline doctor Ma Yonggang is beginning to see light at the end of the tunnel. In an online video interview -- arranged by China'... "The patient consulted a private general practitioner on 3 March with symptoms of fever, headache, malaise, a sore throat and a cough." The practice nurse then took swabs and delivered it to the laboratory. The patient has been self-isolating since 3 March. "The couple also has two children. The Emergency Operating Centre (EOC) has identified the contacts by interviewing the patient and doctor. The tracer team has been deployed to KwaZulu-Natal with epidemiologists and clinicians from the NICD." Mkhize said the doctor has been self-isolated as well. "This media briefing is to ensure that the public is immediately kept abreast. A press briefing will be held later after the Parliamentary debate this evening to shed more light on this issue." Source: https://m.news24.com/SouthAfrica/News/breaking-sas-first-positive-case-of-covid-19-confirmed-20200305 |
TAG4:Practice makes perfect... Dont worry.. When you guys get married and u drain him out in few days.. He will start learning aw to delay by using his mind... I used to be like that too before marriage... Now it's wifey that tells me ' you can cum now'� He should also exercise.. It helps alot...along with his mind... I can hold for 40mins straight with these combination |
beardedboy:You see aw slow spoke you are.. Is mother a religion... No wonder you sound dimential.... Is Mohamed ur mother or father? |
OgunLaakaye:School him...and let's hear you denying a fact |
beardedboy:It is you that has religion intolerance... There is freedom I'd speech and no one should be hanged for speaking his mind... Yes, peolle kick for calling thier messiah gay but not to the extent of burning houses n chasing thier family out of town... You guys will always find a way to defend your backwardness and defend your prophet even when they speak the truth.. For instance, they call him pedophile for marrying and sleeping with a 9year old girl but u kick n protest as if that was not a fact... What sane human sleeps with a 9year old girl that doesn't even have breast of hair in her private part |
A good wife is a blessing from the lord... God bless her beautiful hearth... I also have one like this at home and can't thank God enough for giving her to me... |
lol

